Entity Details

Primary name NMDE2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13224
EntryNameNMDE2_HUMAN
FullNameGlutamate receptor ionotropic, NMDA 2B
TaxID9606
Evidenceevidence at protein level
Length1484
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesGRIN2B

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001540 amyloid-beta binding
GO:0004972 NMDA glutamate receptor activity
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007215 glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007275 multicellular organism development
GO:0007420 brain development
GO:0007611 learning or memory
GO:0008270 zinc ion binding
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0015276 ligand-gated ion channel activity
GO:0016594 glycine binding
GO:0016595 glutamate binding
GO:0017146 NMDA selective glutamate receptor complex
GO:0022849 glutamate-gated calcium ion channel activity
GO:0038023 signaling receptor activity
GO:0043005 neuron projection
GO:0045211 postsynaptic membrane
GO:0045471 response to ethanol
GO:0048013 ephrin receptor signaling pathway
GO:0048167 regulation of synaptic plasticity
GO:0051290 protein heterotetramerization
GO:0060079 excitatory postsynaptic potential
GO:0060291 long-term synaptic potentiation
GO:0097060 synaptic membrane
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098839 postsynaptic density membrane
GO:0098976 excitatory chemical synaptic transmission
GO:1901216 positive regulation of neuron death
GO:1902951 negative regulation of dendritic spine maintenance
GO:2000310 regulation of NMDA receptor activity
GO:2001056 positive regulation of cysteine-type endopeptidase activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Late endosome
Lysosome

Domains

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DomainNameCategoryType
IPR001320 Ionotropic glutamate receptorDomainDomain
IPR001508 Ionotropic glutamate receptor, metazoaFamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminalDomainDomain
IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomainDomain
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00289 AtomoxetineDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00659 AcamprosateDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00874 GuaifenesinDrugbanksmall molecule
DB00949 FelbamateDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01520 TenocyclidineDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB01956 TaurineDrugbanksmall molecule
DB04896 MilnacipranDrugbanksmall molecule
DB05956 EVT-101Drugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06151 AcetylcysteineDrugbanksmall molecule
DB06738 KetobemidoneDrugbanksmall molecule
DB06741 GavestinelDrugbanksmall molecule
DB08954 IfenprodilDrugbanksmall molecule
DB09409 Magnesium acetate tetrahydrateDrugbanksmall molecule
DB09481 Magnesium carbonateDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule
DB13146 Fluciclovine (18F)Drugbanksmall molecule

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
NMDE2_HUMANMAGI3_HUMANHPRD, MINT10748157 details
NMDE2_HUMANDLG4_HUMANBioGRID, DIP, HPRD, MINT10488080 11723117 11937501 11997254 12738960 16332682 16990796 17459877 20018661 20869595 7569905 8601796 9278515 9581762 details
NMDE2_HUMANPTPRC_HUMANIntAct19167335 details
NMDE2_HUMANPTPRG_HUMANIntAct19167335 details
NMDE2_HUMANPTPRB_HUMANIntAct19167335 details
NMDE2_HUMANPTPRJ_HUMANIntAct19167335 details
NMDE2_HUMANPTN12_HUMANIntAct19167335 details
NMDE2_HUMANKCC2A_HUMANBioGRID, MINT11459059 16436603 19453375 9694809 details
NMDE2_HUMANDLG1_HUMANBioGRID, HPRD, IntAct, MINT11997254 24550280 30126976 8601796 details
NMDE2_HUMANSCRIB_HUMANIntAct30126976 details
NMDE2_HUMANRHG32_HUMANBioGRID, HPRD12531901 12857875 details
NMDE2_HUMANDLG3_HUMANBioGRID, HPRD11937501 11997254 12738960 8780649 9278515 details
NMDE2_HUMANEXOC7_HUMANBioGRID12738960 details
NMDE2_HUMANDLG2_HUMANBioGRID, HPRD11997254 12890763 9278515 9806853 details
NMDE2_HUMANERBIN_HUMANBioGRID11278603 details
NMDE2_HUMANACTN2_HUMANBioGRID, HPRD9009191 details
NMDE2_HUMANNMDZ1_HUMANBioGRID, HPRD12191494 12391275 15030493 15888440 17459877 18233995 19487695 19811606 23621516 8139656 details
NMDE2_HUMANFYN_HUMANBioGRID, HPRD10458595 11024032 11483655 9670010 details
NMDE2_HUMANLIN7B_HUMANBioGRID, HPRD10341223 details
NMDE2_HUMANLIN7A_HUMANBioGRID, HPRD10341223 details
NMDE2_HUMANMIB2_HUMANBioGRID17962190 details
NMDE2_HUMANSPTN1_HUMANBioGRID9670010 details
NMDE2_HUMANKCC2G_HUMANBioGRID28636948 9670010 details
NMDE2_HUMANKPCA_HUMANBioGRID, HPRD11306676 12147342 8940188 9670010 details
NMDE2_HUMANEGFR_HUMANBioGRID30298963 details
NMDE2_HUMANNMDE2_HUMANBioGRID, HPRD10458595 15888440 details
NMDE2_HUMANNMDE1_HUMANBioGRID15888440 details
NMDE2_HUMANRGRF1_HUMANBioGRID14622581 details
NMDE2_HUMANCSK22_HUMANBioGRID20869595 details
NMDE2_HUMANCSK21_HUMANBioGRID20869595 details
NMDE2_HUMANCSK2B_HUMANBioGRID20869595 details
NMDE2_HUMANAP1M1_HUMANBioGRID, HPRD15254094 details
NMDE2_HUMANAP2M1_HUMANBioGRID, HPRD15254094 details
NMDE2_HUMANAP4M1_HUMANBioGRID, HPRD15254094 details
NMDE2_HUMANIL16_HUMANHPRD10479680 details
NMDE2_HUMANCAN1_HUMANBioGRID, HPRD, IntAct10846184 25241761 details
NMDE2_HUMANPRKN_HUMANBioGRID, HPRD, IntAct11679592 25241761 details
NMDE2_HUMANDPYL2_HUMANUniProt30871964 details
NMDE2_HUMANEXOC4_HUMANBioGRID, HPRD12738960 details
NMDE2_HUMANEXOC3_HUMANBioGRID12738960 details
NMDE2_HUMANRACK1_HUMANBioGRID, HPRD12524444 details
NMDE2_HUMANKDM5B_HUMANBioGRID19336002 details
NMDE2_HUMANAPLP1_HUMANBioGRID25683482 details
NMDE2_HUMANAPLP2_HUMANBioGRID25683482 details
NMDE2_HUMANA4_HUMANBioGRID19811606 23621516 details
NMDE2_HUMANNETO1_HUMANBioGRID23621516 details
NMDE2_HUMANEAA3_HUMANBioGRID17459877 details
NMDE2_HUMANEPHB2_HUMANHPRD11799243 details
NMDE2_HUMANPTN11_HUMANHPRD10381539 details
NMDE2_HUMANKCC2D_HUMANHPRD16120608 16436603 details
NMDE2_HUMANKCC2B_HUMANHPRD11306676 12147342 16436603 8940188 details
NMDE2_HUMANPK3CA_HUMANHPRD10620012 details
NMDE2_HUMANKPCB_HUMANHPRD11306676 12147342 8940188 details
NMDE2_HUMANKPCG_HUMANHPRD11306676 12147342 8940188 details
NMDE2_HUMANSRC_HUMANHPRD10884433 11024032 11483655 details
NMDE2_HUMANNMD3A_HUMANHPRD12391275 details
NMDE2_HUMANCK2N1_HUMANHPRD12650977 details
NMDE2_HUMANSYGP1_HUMANHPRD9620694 details
NMDE2_HUMANTANC1_HUMANHPRD15673434 details
NMDE2_HUMANPLCG1_HUMANHPRD9231720 details