Entity Details

Primary name ADRA1A
Entity type gene
Source Source Link

Details

PrimaryID148
RefseqGeneNG_029395
SymbolADRA1A
Nameadrenoceptor alpha 1A
Chromosome8
Location8p21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-09-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsADA1A_HUMAN

GO terms

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GOName
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0004930 G protein-coupled receptor activity
GO:0004937 alpha1-adrenergic receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006915 apoptotic process
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007512 adult heart development
GO:0007568 aging
GO:0008285 negative regulation of cell population proliferation
GO:0009725 response to hormone
GO:0010507 negative regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031965 nuclear membrane
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042493 response to drug
GO:0043231 intracellular membrane-bounded organelle
GO:0043410 positive regulation of MAPK cascade
GO:0045760 positive regulation of action potential
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0046982 protein heterodimerization activity
GO:0060073 micturition
GO:0060402 calcium ion transport into cytosol
GO:0060452 positive regulation of cardiac muscle contraction
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090037 positive regulation of protein kinase C signaling
GO:0097195 pilomotor reflex
GO:0098691 dopaminergic synapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0150099 neuron-glial cell signaling
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:2000300 regulation of synaptic vesicle exocytosis

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
ADRA1ABMP1HPRD, IntAct15525470 details
ADRA1AABRHPRD, IntAct15525470 details
ADRA1AFLNCHPRD, IntAct15525470 details
ADRA1AATP6AP2BioGRID, MINT28298427 details
ADRA1ACD81BioGRID, MINT28298427 details
ADRA1ATMEM234BioGRID, MINT28298427 details
ADRA1AFAM50BBioGRID, MINT28298427 details
ADRA1AFAM241BBioGRID, MINT28298427 details
ADRA1AGDE1BioGRID, MINT28298427 details
ADRA1AGPR37BioGRID, MINT28298427 details
ADRA1AADGRA3BioGRID, MINT28298427 details
ADRA1AHHATLBioGRID, MINT28298427 details
ADRA1AKLHL22BioGRID, MINT28298427 details
ADRA1AKIAA2013BioGRID, MINT28298427 details
ADRA1ATBC1D20BioGRID, MINT28298427 details
ADRA1AMBOAT7BioGRID, MINT28298427 details
ADRA1AANO8BioGRID, MINT28298427 details
ADRA1ATPCN2BioGRID, MINT28298427 details
ADRA1ASGCBBioGRID, MINT28298427 details
ADRA1ASCN1BBioGRID, MINT28298427 details
ADRA1ANTNG2BioGRID, MINT28298427 details
ADRA1AUGT8BioGRID, MINT28298427 details
ADRA1AUBR4BioGRID, MINT28298427 details
ADRA1ACRELD1IntAct20508391 details
ADRA1AADRA1ABioGRID, IntAct12888550 14645668 details
ADRA1AADRA1BBioGRID, HPRD, IntAct12888550 14645668 15525470 details
ADRA1AADRA1DHPRD15525470 details
ADRA1ACLTCIntAct23460120 details
ADRA1ACLTAIntAct23460120 details
ADRA1ACLTBIntAct23460120 details
ADRA1AACKR3IntAct28862946 details
ADRA1ACXCR4IntAct25775528 27331810 28862946 details
ADRA1ARGS2HPRD15917235 details
ADRA1ACXCR2HPRD15946947 details
ADRA1ACXCR1HPRD15946947 details
ADRA1ANOS1HPRD12184796 details
ADRA1APPP1R9BHPRD11154706 details
ADRA1ARAB31BioGRID, IntAct30021884 details
ADRA1AVIMBioGRID, IntAct30021884 details
ADRA1ARNF123BioGRID29676528 details
ADRA1ADDX58BioGRID32513696 details