Entity Details

Primary name DHFR
Entity type gene
Source Source Link

Details

PrimaryID1719
RefseqGeneNG_023304
SymbolDHFR
Namedihydrofolate reductase
Chromosome5
Location5q14.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1988-06-01
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsDYR_HUMAN

GO terms

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GOName
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000900 translation repressor activity, mRNA regulatory element binding
GO:0003729 mRNA binding
GO:0004146 dihydrofolate reductase activity
GO:0005542 folic acid binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006545 glycine biosynthetic process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0008144 drug binding
GO:0017148 negative regulation of translation
GO:0031103 axon regeneration
GO:0031427 response to methotrexate
GO:0046452 dihydrofolate metabolic process
GO:0046653 tetrahydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
GO:0050661 NADP binding
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051870 methotrexate binding
GO:0070402 NADPH binding
GO:1990825 sequence-specific mRNA binding
GO:2000121 regulation of removal of superoxide radicals

Diseases

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