Entity Details

Primary name RUNX3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13761
EntryNameRUNX3_HUMAN
FullNameRunt-related transcription factor 3
TaxID9606
Evidenceevidence at protein level
Length415
SequenceStatuscomplete
DateCreated2001-11-02
DateModified2021-06-02

Ontological Relatives

GenesRUNX3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001503 ossification
GO:0002062 chondrocyte differentiation
GO:0003700 DNA-binding transcription factor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0016513 core-binding factor complex
GO:0030097 hemopoiesis
GO:0030182 neuron differentiation
GO:0043231 intracellular membrane-bounded organelle
GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045595 regulation of cell differentiation
GO:0045786 negative regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048935 peripheral nervous system neuron development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0071559 response to transforming growth factor beta
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000040 Acute myeloid leukemia 1 protein (AML1)/RuntFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013524 Runt domainDomainDomain
IPR013711 Runx, C-terminal domainDomainDomain
IPR016554 Runt-related transcription factor RUNXFamilyFamily

Diseases

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Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
RUNX3_HUMANTLE1_HUMANBioGRID, HPRD, IntAct9751710 details
RUNX3_HUMANGUCD1_HUMANBioGRID, IntAct32296183 details
RUNX3_HUMANPEBB_HUMANBioGRID, HPRD, IntAct15138260 23333304 31253590 32296183 7622058 details
RUNX3_HUMANSP110_HUMANBioGRID, IntAct20211142 details
RUNX3_HUMANYAP1_HUMANBioGRID10228168 details
RUNX3_HUMANNOTC1_HUMANBioGRID19800882 details
RUNX3_HUMANMYCN_HUMANBioGRID23851507 details
RUNX3_HUMANP53_HUMANBioGRID20353948 details
RUNX3_HUMANGLI1_HUMANBioGRID31278361 details
RUNX3_HUMANCTNB1_HUMANIntAct18772112 details
RUNX3_HUMANTF7L2_HUMANIntAct18772112 details
RUNX3_HUMANTCF7_HUMANIntAct18772112 details
RUNX3_HUMANBRD2_HUMANIntAct24229708 details
RUNX3_HUMANHDAC4_HUMANHPRD, IntAct15138260 24229708 details
RUNX3_HUMANHDAC5_HUMANBioGRID, HPRD, IntAct15138260 24229708 details
RUNX3_HUMANEP300_HUMANBioGRID, HPRD, IntAct15138260 24229708 details
RUNX3_HUMANSMAD3_HUMANBioGRID, HPRD10531362 15138260 27497248 details
RUNX3_HUMANSMAD1_HUMANBioGRID10531362 details
RUNX3_HUMANSMAD2_HUMANBioGRID10531362 details
RUNX3_HUMANSMAD5_HUMANBioGRID10531362 details
RUNX3_HUMANSUV91_HUMANBioGRID16652147 details
RUNX3_HUMANSMUF1_HUMANBioGRID, HPRD15138260 details
RUNX3_HUMANSMUF2_HUMANBioGRID, HPRD15138260 details
RUNX3_HUMANEZH2_HUMANBioGRID20714105 details
RUNX3_HUMANMDM2_HUMANBioGRID19808967 details
RUNX3_HUMANSIR2_HUMANBioGRID21511279 details
RUNX3_HUMANSUH_HUMANBioGRID19800882 details
RUNX3_HUMANPIN1_HUMANBioGRID22580604 details
RUNX3_HUMANPML_HUMANBioGRID15331439 details
RUNX3_HUMANHDAC1_HUMANBioGRID, HPRD15138260 details
RUNX3_HUMANFACD2_HUMANBioGRID25066130 details
RUNX3_HUMANFANCI_HUMANBioGRID25066130 details
RUNX3_HUMANDZIP3_HUMANBioGRID29417297 details
RUNX3_HUMANMEX3B_HUMANBioGRID29417297 details
RUNX3_HUMANHIF1A_HUMANBioGRID23542169 details
RUNX3_HUMANEGLN2_HUMANBioGRID23542169 details
RUNX3_HUMANEGLN1_HUMANBioGRID23542169 details
RUNX3_HUMANSUFU_HUMANBioGRID31278361 details
RUNX3_HUMANHDAC2_HUMANHPRD15138260 details