Entity Details

Primary name EIF4E
Entity type gene
Source Source Link

Details

PrimaryID1977
RefseqGeneNG_047048
SymbolEIF4E
Nameeukaryotic translation initiation factor 4E
Chromosome4
Location4q23
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-01-07
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsIF4E_HUMAN

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000339 RNA cap binding
GO:0000340 RNA 7-methylguanosine cap binding
GO:0000932 P-body
GO:0001662 behavioral fear response
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005845 mRNA cap binding complex
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0010494 cytoplasmic stress granule
GO:0016032 viral process
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0016442 RISC complex
GO:0017148 negative regulation of translation
GO:0019827 stem cell population maintenance
GO:0019899 enzyme binding
GO:0030324 lung development
GO:0031370 eukaryotic initiation factor 4G binding
GO:0033391 chromatoid body
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0045665 negative regulation of neuron differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0071549 cellular response to dexamethasone stimulus
GO:0098978 glutamatergic synapse
GO:0099524 postsynaptic cytosol
GO:0099578 regulation of translation at postsynapse, modulating synaptic transmission

Diseases

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Interactions

119 interactions

InteractorPartnerSourcesPublicationsLink
EIF4EEIF4EBP1BioGRID, DIP, HPRD, IntAct, MINT10364159 10405182 10698949 10753870 10772338 11553333 11605658 12071973 12588975 12747804 12867426 15094042 15153109 15767663 16189514 16242075 16271312 16504179 16648488 16798736 16824195 17254965 17353931 18955708 18957614 19834456 20224576 20880835 21191102 21798997 22509910 22586265 22678294 24211447 24722188 24931163 24981860 25416956 25940091 26186194 26344197 28514442 32296183 7651417 7935836 8816458 details
EIF4EEIF4EBP2BioGRID, DIP, HPRD, IntAct, MINT15153109 16271312 20347422 24207126 24722188 24981860 25416956 26186194 26344197 28514442 31515488 32296183 7651417 7935836 8939971 details
EIF4EEIF4EBP3BioGRID, HPRD, IntAct, MINT12482586 15153109 16271312 24722188 25416956 32296183 9593750 details
EIF4EEIF4ENIF1BioGRID, HPRD, IntAct, MINT10856257 16467844 19060904 24722188 24981860 25416956 25923732 26186194 28514442 29395067 details
EIF4EEIF4G1BioGRID, DIP, HPRD, IntAct, MINT10600798 10753870 12071973 15153109 15361857 16281055 16541103 16648488 16720573 18955708 20212144 21191102 22509910 22586265 23665581 24981860 25923732 25940091 26186194 26344197 27864334 28514442 29987188 30573685 7651417 9372926 9418880 details
EIF4EGEMIN5BioGRID, IntAct16739988 details
EIF4ECYFIP1IntAct18805096 details
EIF4EPMLBioGRID, HPRD, MINT11500381 11575918 12167712 12438698 19262567 details
EIF4ECD83BioGRID, IntAct21988832 details
EIF4EPRDM4BioGRID, IntAct21988832 details
EIF4ETRIM27BioGRID, IntAct24722188 25416956 31515488 details
EIF4ETDO2BioGRID, IntAct24722188 25416956 details
EIF4EUBXN11BioGRID, IntAct24722188 25416956 details
EIF4EKANK2BioGRID, IntAct24722188 25416956 32296183 details
EIF4EEIF4G3BioGRID, DIP, HPRD, IntAct, MINT20212144 21191102 24981860 26186194 26344197 28514442 9418880 details
EIF4EAPPBioGRID21832049 details
EIF4EBIRC2BioGRID28852129 details
EIF4EPTENBioGRID31685992 details
EIF4EMKNK1BioGRID, HPRD, MINT10022874 9155017 9878069 details
EIF4EEMX2HPRD, IntAct15247416 details
EIF4EEIF4A2BioGRID, IntAct, MINT17353931 24981860 29395067 details
EIF4EPAK2IntAct17353931 details
EIF4ESMYD2IntAct17353931 details
EIF4EEIF4A1BioGRID, IntAct, MINT16648488 17353931 22586265 24981860 28514442 29395067 details
EIF4ETRAF6IntAct17353931 details
EIF4EEIF3BBioGRID, IntAct, MINT16541103 18423201 24981860 30573685 details
EIF4EG3BP1BioGRID, MINT18005740 29395067 details
EIF4EDDX3XMINT, UniProt18596238 19262567 21883093 22872150 details
EIF4ELRPPRCMINT19262567 details
EIF4ESUMO1MINT20224576 details
EIF4EPPP2CAMINT20927323 details
EIF4EPABPC1BioGRID, DIP23665581 26344197 29395067 details
EIF4EEIF3FBioGRID, MINT19615732 24981860 30573685 details
EIF4EEIF3ABioGRID, MINT24981860 30573685 details
EIF4ESTUB1BioGRID16720573 28852129 details
EIF4EDCCBioGRID20434207 details
EIF4EHSPB2BioGRID20101233 details
EIF4ERPTORBioGRID16798736 details
EIF4EITGA4BioGRID22623428 details
EIF4ETRIM22BioGRID22509910 details
EIF4EOTUD6BBioGRID27864334 details
EIF4ESRSF3BioGRID27381497 details
EIF4EMETTL3BioGRID30232453 details
EIF4EFMR1BioGRID30361391 details
EIF4ECTNNB1BioGRID30361391 details
EIF4EPATL1BioGRID29395067 details
EIF4EYTHDF2BioGRID29395067 details
EIF4EZFP36BioGRID29395067 details
EIF4ECELF1BioGRID29395067 details
EIF4EEIF4EHPRD12482586 details
EIF4EPRKCAHPRD8662663 details
EIF4EPRKCBHPRD8662663 details
EIF4EPRKCGHPRD8662663 details
EIF4EEIF4BHPRD2016328 details
EIF4EMKNK2HPRD12897141 9155017 details
EIF4EEIF4G2HPRD10394359 details
EIF4EMAPKAPK5HPRD9628874 details
EIF4EINTS6MINT17469741 details
EIF4ERPS6KB1BioGRID, IntAct18423201 details
EIF4EMTORBioGRID, IntAct18423201 details
EIF4ERPS6DIP, IntAct18423201 18955708 details
EIF4ENXF1MINT19262567 details
EIF4EDDX39BMINT19262567 details
EIF4EHNRNPA1MINT19262567 details
EIF4EEIF3HBioGRID, IntAct, MINT19615732 24981860 details
EIF4EAGO2MINT20395958 details
EIF4EVCAM1IntAct22623428 details
EIF4EIRS1MINT23770097 details
EIF4EHIF1ANBioGRID, IntAct26972000 details
EIF4EANGEL1BioGRID, IntAct, MINT24981860 26186194 28514442 details
EIF4ERBM4DIP17284590 details
EIF4EUPF1DIP23665581 details
EIF4ENCBP1DIP23665581 details
EIF4EMAPTUniProt26269332 details
EIF4EESR1BioGRID, IntAct31527615 details
EIF4EEIF3EBioGRID, MINT24981860 details
EIF4EEIF3MBioGRID, MINT24981860 details
EIF4ERPS27LBioGRID, MINT24981860 details
EIF4EEIF3KBioGRID, MINT24981860 details
EIF4EEIF3CBioGRID, MINT24981860 details
EIF4EEIF3IBioGRID, MINT24981860 details
EIF4EEIF3LBioGRID, MINT24981860 details
EIF4EEIF3GBioGRID, MINT24981860 details
EIF4EEIF3DBioGRID, MINT24981860 details
EIF4EEIF4HBioGRID22939629 details
EIF4EAHSA1BioGRID22863883 details
EIF4EASS1BioGRID22863883 details
EIF4ECAPN1BioGRID22863883 details
EIF4EHSPA9BioGRID22863883 details
EIF4ENANSBioGRID22863883 details
EIF4EEIF6BioGRID22863883 details
EIF4EHSPD1BioGRID22863883 details
EIF4EPEPDBioGRID22863883 details
EIF4EPLPBPBioGRID22863883 details
EIF4ETYMPBioGRID22863883 details
EIF4EDDX19ABioGRID26344197 details
EIF4ECSKBioGRID26344197 details
EIF4EUBFD1BioGRID26344197 details
EIF4EPABPC3BioGRID26344197 details
EIF4EPABPC4BioGRID26344197 details
EIF4EPDXKBioGRID26344197 details
EIF4ENTRK1BioGRID25921289 details
EIF4ECYLDBioGRID27591049 details
EIF4EPYHIN1BioGRID28077445 details
EIF4EEFTUD2BioGRID28515276 details
EIF4EPIH1D1BioGRID28515276 details
EIF4EESR2BioGRID29509190 details
EIF4ERNF123BioGRID29676528 details
EIF4ERECQL4BioGRID29229926 details
EIF4ECDK9BioGRID26209609 details
EIF4EDYNC1I1BioGRID28718761 details
EIF4EBIRC3BioGRID30948266 details
EIF4ENFX1BioGRID31059266 details
EIF4EPLEKHA4BioGRID31091453 details
EIF4EDCP1ABioGRID29395067 details
EIF4EDDX6BioGRID29395067 details
EIF4EDDRGK1BioGRID32807901 details
EIF4EELAVL1BioGRID29931370 details
EIF4ENFKBIZBioGRID29471506 details