Entity Details

Primary name BMPR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13873
EntryNameBMPR2_HUMAN
FullNameBone morphogenetic protein receptor type-2
TaxID9606
Evidenceevidence at protein level
Length1038
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesBMPR2

GO terms

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GOName
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001707 mesoderm formation
GO:0001893 maternal placenta development
GO:0001935 endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0002063 chondrocyte development
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003176 aortic valve development
GO:0003177 pulmonary valve development
GO:0003183 mitral valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003252 negative regulation of cell proliferation involved in heart valve morphogenesis
GO:0004674 protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005905 clathrin-coated pit
GO:0005912 adherens junction
GO:0006468 protein phosphorylation
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007420 brain development
GO:0009267 cellular response to starvation
GO:0009925 basal plasma membrane
GO:0009952 anterior/posterior pattern specification
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014069 postsynaptic density
GO:0014916 regulation of lung blood pressure
GO:0016324 apical plasma membrane
GO:0019838 growth factor binding
GO:0030166 proteoglycan biosynthetic process
GO:0030308 negative regulation of cell growth
GO:0030425 dendrite
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0036122 BMP binding
GO:0042127 regulation of cell population proliferation
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0044214 spanning component of plasma membrane
GO:0045296 cadherin binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045906 negative regulation of vasoconstriction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048286 lung alveolus development
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0051148 negative regulation of muscle cell differentiation
GO:0060173 limb development
GO:0060350 endochondral bone morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0060836 lymphatic endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0061036 positive regulation of cartilage development
GO:0061298 retina vasculature development in camera-type eye
GO:0061626 pharyngeal arch artery morphogenesis
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:0072577 endothelial cell apoptotic process
GO:0098821 BMP receptor activity
GO:1902731 negative regulation of chondrocyte proliferation
GO:1905314 semi-lunar valve development
GO:1990782 protein tyrosine kinase binding
GO:2000279 negative regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015770 Bone morphogenetic protein receptor type-2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Disease IDSourceNameDescription
265450 OMIMPulmonary venoocclusive disease 1, autosomal dominant (PVOD1)A disease characterized by widespread fibrous obstruction and intimal thickening of septal veins and preseptal venules, a low diffusing capacity for carbon monoxide, occult alveolar hemorrhage, and nodular ground-glass opacities, septal lines and lymph node enlargement showed by high-resolution computed tomography of the chest. It is frequently associated with pulmonary capillary dilatation and proliferation, and is a rare and devastating cause of pulmonary hypertension. The disease is caused by variants affecting the gene represented in this entry.
178600 OMIMPulmonary hypertension, primary, 1 (PPH1)A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB11639 Dibotermin alfaDrugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule

Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
BMPR2_HUMANGDF5_HUMANBioGRID, HPRD, MINT19229295 9525338 details
BMPR2_HUMANMK08_HUMANBioGRID, MINT21900206 details
BMPR2_HUMANHSC20_HUMANDIP24606901 details
BMPR2_HUMANACVR1_HUMANBioGRID, IntAct28514442 7791754 7890683 details
BMPR2_HUMANBMP2_HUMANBioGRID, DIP, HPRD10712517 10880444 25938661 7791754 details
BMPR2_HUMANLIMK1_HUMANBioGRID, HPRD12963706 details
BMPR2_HUMANTGFR1_HUMANBioGRID7791754 7890683 details
BMPR2_HUMANACV1B_HUMANBioGRID7791754 details
BMPR2_HUMANTSR1_HUMANBioGRID7791754 details
BMPR2_HUMANBMP7_HUMANBioGRID, HPRD7644468 7791754 details
BMPR2_HUMANGDF6_HUMANBioGRID, HPRD9525338 details
BMPR2_HUMANBMP4_HUMANBioGRID, HPRD12045205 28126904 7644468 8702914 details
BMPR2_HUMANGDF9_HUMANBioGRID, HPRD12135884 details
BMPR2_HUMANFHL2_HUMANBioGRID19265191 details
BMPR2_HUMANTRIB3_HUMANBioGRID17576816 details
BMPR2_HUMANPP1G_HUMANBioGRID23080069 details
BMPR2_HUMANGDF2_HUMANBioGRID17311849 22718755 details
BMPR2_HUMANBMP10_HUMANBioGRID22718755 details
BMPR2_HUMANTDGF1_HUMANBioGRID28126904 details
BMPR2_HUMANINHBB_HUMANBioGRID28126904 details
BMPR2_HUMANKIT_HUMANBioGRID16155937 details
BMPR2_HUMANSMUF1_HUMANBioGRID31578224 details
BMPR2_HUMANDYLT1_HUMANBioGRID, HPRD14583445 31578224 details
BMPR2_HUMANKGP1_HUMANMINT19424179 details
BMPR2_HUMANBMR1A_HUMANBioGRID, HPRD10712517 7791754 details
BMPR2_HUMANBMR1B_HUMANBioGRID, HPRD10712517 7791754 details
BMPR2_HUMANBMP6_HUMANBioGRID, HPRD10504300 11401330 details
BMPR2_HUMANBMPR2_HUMANBioGRID, HPRD10712517 details
BMPR2_HUMANXIAP_HUMANBioGRID19782107 details
BMPR2_HUMANFST_HUMANBioGRID16198295 details
BMPR2_HUMANSMAD6_HUMANBioGRID20663871 details
BMPR2_HUMANSMAD7_HUMANBioGRID20663871 details
BMPR2_HUMANCAV1_HUMANBioGRID15657086 details
BMPR2_HUMANEGLN_HUMANBioGRID23967299 details
BMPR2_HUMANAVR2A_HUMANBioGRID23967299 details
BMPR2_HUMANCADH5_HUMANBioGRID26598555 details
BMPR2_HUMANKPCB_HUMANHPRD15188402 details
BMPR2_HUMANMOS_HUMANHPRD15188402 details
BMPR2_HUMANTBB2A_HUMANHPRD15188402 details
BMPR2_HUMANM3K8_HUMANHPRD15188402 details
BMPR2_HUMANLMX1A_HUMANHPRD15188402 details
BMPR2_HUMANPGTA_HUMANHPRD15188402 details
BMPR2_HUMANCTBP1_HUMANHPRD15188402 details
BMPR2_HUMANTBB4A_HUMANHPRD15188402 details
BMPR2_HUMANMERTK_HUMANHPRD15188402 details
BMPR2_HUMANNBEA_HUMANHPRD15188402 details
BMPR2_HUMANHNRPR_HUMANHPRD15188402 details
BMPR2_HUMANFOXL1_HUMANHPRD15188402 details
BMPR2_HUMANMPPA_HUMANHPRD15188402 details
BMPR2_HUMANOC90_HUMANHPRD15188402 details
BMPR2_HUMANCCD89_HUMANHPRD15188402 details
BMPR2_HUMANST1E1_HUMANHPRD15188402 details
BMPR2_HUMANARSA_HUMANHPRD15188402 details
BMPR2_HUMANARP8_HUMANHPRD15188402 details
BMPR2_HUMANNOP56_HUMANHPRD15188402 details
BMPR2_HUMANTWF1_HUMANHPRD15188402 details
BMPR2_HUMANTRPC1_HUMANHPRD15188402 details
BMPR2_HUMANLSM10_HUMANHPRD15188402 details
BMPR2_HUMANPZRN3_HUMANHPRD15188402 details
BMPR2_HUMANTOPB1_HUMANHPRD15188402 details
BMPR2_HUMANEST1_HUMANHPRD15188402 details
BMPR2_HUMANC4BPA_HUMANHPRD15188402 details
BMPR2_HUMANLSP1_HUMANHPRD15188402 details