Entity Details

Primary name FGF2
Entity type gene
Source Source Link

Details

PrimaryID2247
RefseqGeneNG_029067
SymbolFGF2
Namefibroblast growth factor 2
Chromosome4
Location4q28.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1992-02-20
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsFGF2_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0005104 fibroblast growth factor receptor binding
GO:0005125 cytokine activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0007399 nervous system development
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010764 negative regulation of fibroblast migration
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014843 growth factor dependent regulation of skeletal muscle satellite cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0019956 chemokine binding
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0030214 hyaluronan catabolic process
GO:0030324 lung development
GO:0030334 regulation of cell migration
GO:0030374 nuclear receptor coactivator activity
GO:0032958 inositol phosphate biosynthetic process
GO:0035019 somatic stem cell population maintenance
GO:0038001 paracrine signaling
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042056 chemoattractant activity
GO:0042060 wound healing
GO:0042660 positive regulation of cell fate specification
GO:0042802 identical protein binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048598 embryonic morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060548 negative regulation of cell death
GO:0060591 chondroblast differentiation
GO:0061045 negative regulation of wound healing
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072089 stem cell proliferation
GO:0090049 regulation of cell migration involved in sprouting angiogenesis
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090722 receptor-receptor interaction
GO:1902748 positive regulation of lens fiber cell differentiation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903672 positive regulation of sprouting angiogenesis
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905278 positive regulation of epithelial tube formation
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001028 positive regulation of endothelial cell chemotaxis

Diseases

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Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
FGF2RPS19BioGRID, HPRD, MINT11716516 details
FGF2FGFBP1BioGRID, HPRD, IntAct11509569 16257968 details
FGF2FGFR1BioGRID, DIP, HPRD, IntAct10490103 10748122 10950949 11030354 11786412 14505356 14613973 15096041 15548653 16829530 1697263 17086194 1709094 18199118 19627396 19696444 21693575 22539306 23597562 23597563 26267536 7520751 8609172 8692946 8868466 9174056 details
FGF2FGFR2BioGRID, IntAct, UniProt10830168 11390973 1697263 17981115 18199118 26267536 28514442 9700203 details
FGF2DCNmatrixdb24447999 details
FGF2PTX3BioGRID, HPRD, IntAct16020751 19627396 20363749 22267482 details
FGF2FGFR3HPRD, IntAct10574949 14613973 details
FGF2CSNK2A1BioGRID, HPRD12145206 details
FGF2CSNK2A2BioGRID, HPRD12145206 7735329 details
FGF2CSNK2BBioGRID, HPRD12145206 details
FGF2VTNBioGRID, HPRD11796824 details
FGF2SDC3BioGRID, HPRD16982797 8344959 details
FGF2GPC4BioGRID, HPRD11066092 details
FGF2RPL6BioGRID, HPRD9826564 details
FGF2THBS1BioGRID17996481 details
FGF2CRYABBioGRID17487982 details
FGF2PRMT1BioGRID, HPRD10652299 details
FGF2SNTG1BioGRID8609172 details
FGF2CSPG4BioGRID23124902 details
FGF2NRP1BioGRID, HPRD15695515 30236477 details
FGF2CEP57HPRD12717444 details
FGF2API5HPRD11075807 details
FGF2CASP1HPRD, IntAct18329368 details
FGF2HSPG2HPRD, matrixdb11847221 24509440 details
FGF2CD44BioGRID, HPRD, IntAct28514442 7532176 details
FGF2SDC2BioGRID, HPRD, IntAct16982797 28514442 details
FGF2SDC1BioGRID, HPRD, IntAct16982797 19802384 28514442 details
FGF2SDC4BioGRID16982797 details
FGF2GPC3BioGRID, HPRD12478660 details
FGF2PRKACABioGRID26056081 details
FGF2S100BBioGRID21693575 details
FGF2AGERBioGRID21693575 details
FGF2CREBBPBioGRID22539306 details
FGF2H3-3ABioGRID22539306 details
FGF2FGF2HPRD9558385 details
FGF2RPS6KA3HPRD15879597 details
FGF2FGFR4HPRD8530375 details
FGF2PF4HPRD9558385 details
FGF2CXCL13HPRD11708770 details
FGF2FGFRL1HPRD11418238 details
FGF2ANOS1IntAct19696444 details
FGF2COMTBioGRID, IntAct26496610 details
FGF2TNFAIP6IntAct22267482 details
FGF2MSANTD3-TMEFF1IntAct28514442 details
FGF2TMEFF1BioGRID, IntAct26186194 28514442 details
FGF2PDPK1BioGRID, IntAct31980649 details
FGF2TUBG1BioGRID23443559 details
FGF2IFI16BioGRID25693804 details
FGF2TESBioGRID28378594 details
FGF2CITBioGRID31586073 details
FGF2HNRNPH1BioGRID26760575 details