Entity Details

Primary name SPO11
Entity type gene
Source Source Link

Details

PrimaryID23626
RefseqGene
SymbolSPO11
NameSPO11 initiator of meiotic double stranded breaks
Chromosome20
Location20q13.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSPO11_HUMAN

GO terms

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GOName
GO:0000228 nuclear chromosome
GO:0000706 meiotic DNA double-strand break processing
GO:0000781 chromosome, telomeric region
GO:0001541 ovarian follicle development
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0007130 synaptonemal complex assembly
GO:0007131 reciprocal meiotic recombination
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007292 female gamete generation
GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters
GO:0034502 protein localization to chromosome
GO:0042138 meiotic DNA double-strand break formation
GO:0045141 meiotic telomere clustering
GO:0046872 metal ion binding
GO:0048477 oogenesis
GO:1990918 double-strand break repair involved in meiotic recombination

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SPO11TCF4BioGRID, IntAct32296183 details
SPO11ESR2BioGRID29509190 details