Entity Details

Primary name MTOR
Entity type gene
Source Source Link

Details

PrimaryID2475
RefseqGeneNG_033239
SymbolMTOR
Namemechanistic target of rapamycin kinase
Chromosome1
Location1p36.22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-07-14
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsMTOR_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000139 Golgi membrane
GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0001156 TFIIIC-class transcription factor complex binding
GO:0001558 regulation of cell growth
GO:0001933 negative regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002296 T-helper 1 cell lineage commitment
GO:0003007 heart morphogenesis
GO:0003179 heart valve morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005979 regulation of glycogen biosynthetic process
GO:0006112 energy reserve metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006468 protein phosphorylation
GO:0007040 lysosome organization
GO:0007281 germ cell development
GO:0007420 brain development
GO:0007569 cell aging
GO:0007584 response to nutrient
GO:0007616 long-term memory
GO:0008361 regulation of cell size
GO:0008542 visual learning
GO:0009267 cellular response to starvation
GO:0009791 post-embryonic development
GO:0010507 negative regulation of autophagy
GO:0010592 positive regulation of lamellipodium assembly
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010831 positive regulation of myotube differentiation
GO:0010976 positive regulation of neuron projection development
GO:0012505 endomembrane system
GO:0014042 positive regulation of neuron maturation
GO:0014736 negative regulation of muscle atrophy
GO:0014823 response to activity
GO:0016020 membrane
GO:0016241 regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021510 spinal cord development
GO:0030163 protein catabolic process
GO:0030425 dendrite
GO:0030838 positive regulation of actin filament polymerization
GO:0031397 negative regulation of protein ubiquitination
GO:0031529 ruffle organization
GO:0031641 regulation of myelination
GO:0031667 response to nutrient levels
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0031931 TORC1 complex
GO:0031932 TORC2 complex
GO:0031998 regulation of fatty acid beta-oxidation
GO:0032095 regulation of response to food
GO:0032148 activation of protein kinase B activity
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032868 response to insulin
GO:0032956 regulation of actin cytoskeleton organization
GO:0034198 cellular response to amino acid starvation
GO:0035176 social behavior
GO:0035264 multicellular organism growth
GO:0038202 TORC1 signaling
GO:0042060 wound healing
GO:0042220 response to cocaine
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0043025 neuronal cell body
GO:0043087 regulation of GTPase activity
GO:0043200 response to amino acid
GO:0043276 anoikis
GO:0043278 response to morphine
GO:0043610 regulation of carbohydrate utilization
GO:0045182 translation regulator activity
GO:0045335 phagocytic vesicle
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045670 regulation of osteoclast differentiation
GO:0045727 positive regulation of translation
GO:0045792 negative regulation of cell size
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:0046777 protein autophosphorylation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048255 mRNA stabilization
GO:0048511 rhythmic process
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050882 voluntary musculoskeletal movement
GO:0051219 phosphoprotein binding
GO:0051496 positive regulation of stress fiber assembly
GO:0051549 positive regulation of keratinocyte migration
GO:0051647 nucleus localization
GO:0051897 positive regulation of protein kinase B signaling
GO:0055013 cardiac muscle cell development
GO:0060048 cardiac muscle contraction
GO:0060135 maternal process involved in female pregnancy
GO:0060252 positive regulation of glial cell proliferation
GO:0060999 positive regulation of dendritic spine development
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071230 cellular response to amino acid stimulus
GO:0071233 cellular response to leucine
GO:0071456 cellular response to hypoxia
GO:0090335 regulation of brown fat cell differentiation
GO:0090559 regulation of membrane permeability
GO:0098978 glutamatergic synapse
GO:0099524 postsynaptic cytosol
GO:0099547 regulation of translation at synapse, modulating synaptic transmission
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:1901216 positive regulation of neuron death
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:1903691 positive regulation of wound healing, spreading of epidermal cells
GO:1904000 positive regulation of eating behavior
GO:1904056 positive regulation of cholangiocyte proliferation
GO:1904058 positive regulation of sensory perception of pain
GO:1904059 regulation of locomotor rhythm
GO:1904193 negative regulation of cholangiocyte apoptotic process
GO:1904197 positive regulation of granulosa cell proliferation
GO:1904206 positive regulation of skeletal muscle hypertrophy
GO:1904213 negative regulation of iodide transmembrane transport
GO:1904690 positive regulation of cytoplasmic translational initiation
GO:1990253 cellular response to leucine starvation

Diseases

Show/Hide Table

Interactions

221 interactions

InteractorPartnerSourcesPublicationsLink
MTORMTORBioGRID, DIP, HPRD, MINT10702316 11438723 12030785 16870609 17360675 18030348 24670654 details
MTORAKT1BioGRID, DIP, HPRD, IntAct, MINT10910062 11438723 14970221 15718470 18505677 18566586 18566587 21045808 21177249 21343617 22084251 22337773 23872070 24670654 25241761 25792870 26293922 30639242 details
MTORFKBP1ABioGRID, DIP, HPRD, IntAct, MINT10089303 15268862 15284440 15467718 15796538 17148612 17991864 20639890 20851351 22664266 26344197 29997244 32131492 7822316 8662507 details
MTORRHEBBioGRID, DIP, HPRD, MINT15772076 15854902 15878852 16098514 16631613 16915281 18550814 25351248 details
MTORRICTORBioGRID, DIP, HPRD, IntAct, MINT15268862 15467718 15718470 16183647 16221682 16603397 16919458 16962653 17043309 17277771 17386266 17461779 17565979 18030348 18339839 18504440 18505677 18566586 18566587 18570873 19114562 19145465 19446321 19619545 19875983 20427287 20978191 21045808 21177249 21321085 21343617 21376236 21795849 22084251 22285861 22307628 22544753 22990118 23263282 23297343 23872070 23953116 24036451 24375676 25273559 25897075 27043084 29059166 30865892 31665642 details
MTORPRR5LBioGRID, IntAct17461779 18030348 details
MTORRPTORBioGRID, DIP, HPRD, IntAct, MINT12150925 12150926 12408816 12665511 12718876 12719976 12747827 15066126 15268862 15459249 15467718 16183647 16354680 16603397 16631613 16798736 16837165 1683716516603397 16847060 16919458 16962653 17043309 17277771 17386266 17461779 17565979 18030348 18504440 18505677 18519641 18570873 18722121 18955708 19114562 19145465 19446321 19619545 19875983 20169205 20381137 20427287 21045808 21071439 21177249 21321085 21614075 21795849 22258093 22356909 22424946 22493283 22544753 23263282 23297343 23872070 23911927 23953116 24036451 24337580 24375676 24403073 24516643 25007995 25273559 25332233 25446900 25940091 26348909 26522726 26678875 27043084 29059166 30865892 31601708 details
MTORMLST8BioGRID, DIP, HPRD, IntAct12408816 12718876 12719976 15066126 15459249 16183647 16798736 17277771 17461779 18030348 18504440 18505677 19446321 20427287 20562859 21321085 22084251 22258093 23636326 26186194 26348909 26678875 27173435 28489822 28514442 32433973 unassigned1312 details
MTORTELO2BioGRID, IntAct, UniProt18160036 20801936 details
MTORPREX1BioGRID, IntAct17565979 details
MTORDEPTORBioGRID, IntAct19446321 22017875 22017877 details
MTORAKT1S1BioGRID, HPRD, IntAct17277771 17386266 18030348 18570873 19114562 19446321 23953116 details
MTOREIF4EBP1BioGRID, HPRD, IntAct10364159 10779345 10942774 10971657 11438723 11691836 11777913 12105188 12150925 12150926 12604610 12665511 12747827 15066126 15459249 15767663 15854902 16354698 16798736 16824195 17386266 17693255 17991864 18030348 18337751 18722121 18955708 20537536 21460630 21795849 24931163 25686248 30240640 8083223 9092573 9405468 9465032 details
MTORC7orf25BioGRID, MINT21900206 details
MTORCDC37BioGRID, MINT21900206 details
MTORGSK3BBioGRID, MINT21900206 details
MTORSEPTIN2BioGRID, MINT21900206 details
MTORSIRT1BioGRID, UniProt21471201 26453307 details
MTORSGK1BioGRID, IntAct18570873 27451907 details
MTORBCL2L1BioGRID, DIP, MINT20080789 26593251 details
MTORMAF1BioGRID, DIP20543138 details
MTORUBQLN1BioGRID, HPRD11853878 details
MTORIRS1BioGRID, HPRD11287630 16354680 30240640 details
MTORPRKAA1BioGRID, HPRD14970221 details
MTORRPS6KB1BioGRID, HPRD10567431 10971657 11279232 11914378 12150925 12150926 12604610 12718876 14679009 15066126 15760907 15809305 15854902 15896331 15899889 15905173 16183647 16922504 17386266 18505677 22544753 25738361 28270148 9465032 details
MTORCLIP1BioGRID, HPRD12231510 details
MTOREIF3FBioGRID, HPRD16541103 32131492 details
MTORGPHNBioGRID, HPRD10325225 details
MTORPA2G4BioGRID15896331 details
MTORCFPBioGRID11733037 details
MTORPPP2R2ABioGRID10200280 details
MTORSTAT3BioGRID, HPRD10660304 15522880 23329839 24931163 details
MTORPRKCABioGRID21045808 details
MTOREIF4EBP2BioGRID16798736 details
MTORPDIA3BioGRID21321085 details
MTORAMBRA1BioGRID23524951 details
MTORTRAF6BioGRID23911927 details
MTORYWHAQBioGRID, HPRD10664457 15161933 details
MTORFKBP8BioGRID17991864 24205284 details
MTORGNB1BioGRID24462769 details
MTORRRAGBBioGRID24337580 details
MTORGADD45ABioGRID23329839 details
MTORSUMO1BioGRID20537536 details
MTORDCP2BioGRID26098573 details
MTORZNRF2BioGRID27244671 details
MTORFBXO8BioGRID27916606 details
MTORESR1BioGRID26522726 details
MTORSKP2BioGRID28446188 details
MTOREP300BioGRID29033323 details
MTORHRASBioGRID30639242 details
MTORKRASBioGRID30639242 34079125 details
MTORNRASBioGRID30639242 details
MTORUVRAGBioGRID25533187 details
MTORWIPI2BioGRID30340022 details
MTORRNF126BioGRID32131492 details
MTORPDPK1HPRD, MINT11438723 details
MTORTRAF2BioGRID, IntAct14743216 25241761 details
MTORRHEBL1BioGRID, HPRD, MINT16098514 details
MTORYWHAZBioGRID, MINT15161933 17277771 details
MTORPRR5BioGRID, IntAct17461779 18505677 details
MTORMAPKAP1BioGRID, IntAct, MINT, Molecular Connections16962653 17043309 17277771 17461779 18030348 18505677 18566586 18566587 18570873 19875983 21045808 21177249 21376236 22084251 24365180 26293922 details
MTOREIF3BBioGRID, IntAct16286006 18423201 21045808 details
MTORPREX2BioGRID, IntAct17565979 details
MTORTP53BioGRID, MINT19619545 details
MTORRUVBL1BioGRID, UniProt20371770 22544753 details
MTORRPL26BioGRID, IntAct21045808 21376236 details
MTORTTI1BioGRID, UniProt20427287 20810650 22544753 details
MTORLAMTOR2BioGRID, IntAct20381137 22980980 details
MTORSTAT1BioGRID, IntAct12807916 19553685 25241761 details
MTORTPCN2IntAct23394946 details
MTORTPCN1IntAct23394946 details
MTORRAB1ABioGRID, IntAct25446900 details
MTORRRAGCBioGRID, IntAct21981924 24337580 25446900 28716898 details
MTORMTMR3BioGRID, MINT26787466 details
MTORSMDT1BioGRID, IntAct27173435 unassigned1312 details
MTORXPO4BioGRID, IntAct27173435 unassigned1312 details
MTORXPO6BioGRID, IntAct27173435 unassigned1312 details
MTORTHADABioGRID, IntAct27173435 unassigned1312 details
MTORGTF3C2DIP20543138 details
MTORGTF3C5DIP20543138 details
MTORULK1BioGRID, DIP21460630 23524951 25686248 29321306 details
MTORABL1BioGRID10753870 details
MTORLRPAP1BioGRID16798736 details
MTORPRKCDBioGRID10698949 details
MTOREIF3CBioGRID16286006 details
MTORPLD2BioGRID, HPRD16837165 details
MTORRAP1ABioGRID15854902 details
MTORTERTBioGRID, HPRD15843522 details
MTORFBXW7BioGRID18787170 29346117 31285543 33086033 details
MTORRPL23BioGRID21045808 details
MTORRPS6BioGRID21045808 details
MTORRPL23ABioGRID21045808 details
MTORRPL5BioGRID21045808 details
MTORTERF1BioGRID18160036 details
MTORUSP9XBioGRID22544753 details
MTORRUVBL2BioGRID22544753 details
MTORSQSTM1BioGRID21981924 26279575 details
MTORMAPK8BioGRID22493283 details
MTORRRAGDBioGRID18497260 28716898 details
MTORPMLBioGRID16915281 details
MTORBRCA1BioGRID22990118 details
MTORDDB1BioGRID23297343 details
MTORMETAP2BioGRID19446321 details
MTORHSPA4BioGRID18505677 details
MTOREGFRBioGRID23956138 details
MTORGNG2BioGRID24462769 details
MTORGNB2BioGRID24462769 details
MTORGNB3BioGRID24462769 details
MTORGNB5BioGRID24462769 details
MTORILKBioGRID18339839 details
MTORCHUKBioGRID18490760 18519641 details
MTORIKBKBBioGRID18490760 18519641 details
MTORIKBKGBioGRID18519641 details
MTORNFKBIABioGRID18519641 details
MTORNBNBioGRID23762398 details
MTORGTF3C1BioGRID20543138 details
MTORPRKAR1ABioGRID16963469 details
MTORHTR6BioGRID23027611 details
MTORMLXIPBioGRID25332233 details
MTORMLXIPLBioGRID25332233 details
MTORPDK1BioGRID24516643 details
MTORTNFAIP3BioGRID26043155 29940800 details
MTORRAP2ABioGRID25446900 details
MTORPRKNBioGRID25007995 details
MTORBRAT1BioGRID25657994 details
MTORMAP3K3BioGRID26279575 details
MTORHTTBioGRID25351248 details
MTORIRS2BioGRID27742835 details
MTORMDM4BioGRID28270148 details
MTORLAMP1BioGRID28199306 details
MTORLARP1BioGRID25940091 details
MTORBECN1BioGRID25533187 details
MTORPIK3R4BioGRID25533187 details
MTORPIK3C3BioGRID25533187 details
MTORRUBCNBioGRID25533187 details
MTORLANCL2BioGRID25273559 details
MTORLAMP2BioGRID28199315 29940807 details
MTORSHOC2BioGRID30865892 details
MTORTBK1BioGRID28716898 details
MTORTRIM37BioGRID29940807 details
MTORWWOXBioGRID24008736 details
MTORMCAMBioGRID31665642 details
MTORUBR5BioGRID32867711 details
MTORLNPKBioGRID32433973 details
MTORRPS6KB2HPRD11733037 details
MTORRPS6KA1HPRD15905173 details
MTORRPS9IntAct17461779 details
MTOREIF4EBioGRID, IntAct18423201 details
MTORNCBP1BioGRID, IntAct18423201 details
MTORSTK38BioGRID, MINT19875983 details
MTORRPL7IntAct21376236 details
MTORRPS16IntAct21376236 details
MTORRACK1IntAct21376236 details
MTORLARS1BioGRID, IntAct22424946 details
MTORLAMTOR1IntAct22980980 details
MTORLAMTOR4IntAct22980980 details
MTORLAMTOR5IntAct22980980 details
MTORPIH1D1MINT24036451 details
MTORPRKDCMolecular Connections24365180 details
MTORLLGL2BioGRID, IntAct26496610 details
MTORASPMBioGRID, IntAct26496610 details
MTORVPS16BioGRID, IntAct26496610 details
MTORZSCAN26BioGRID, IntAct26496610 details
MTORNAF1BioGRID, IntAct26496610 details
MTORSGTBBioGRID, IntAct26496610 details
MTORHNRNPDBioGRID, IntAct26496610 details
MTORSYNCRIPBioGRID, IntAct26496610 details
MTORBAG6BioGRID, IntAct26496610 details
MTORYEATS4BioGRID, IntAct26496610 details
MTORDPEP1BioGRID, IntAct28514442 details
MTORBSGBioGRID, IntAct26186194 28514442 details
MTORVIPR2BioGRID, IntAct28514442 details
MTORNPY2RBioGRID, IntAct28514442 details
MTORNTRK3BioGRID, IntAct28514442 details
MTORPACC1BioGRID, IntAct28514442 details
MTORLYPD3BioGRID, IntAct26186194 28514442 details
MTORLEFTY1BioGRID, IntAct28514442 details
MTORRP2BioGRID, IntAct26186194 28514442 details
MTORCA14BioGRID, IntAct26186194 28514442 details
MTORSCN2BBioGRID, IntAct26186194 28514442 details
MTORCD83BioGRID, IntAct28514442 details
MTORNT5EBioGRID, IntAct26186194 28514442 details
MTORSCN3BBioGRID, IntAct28514442 details
MTORVSIG2BioGRID, IntAct26186194 28514442 details
MTORCD274BioGRID, IntAct26186194 28514442 32941674 details
MTORCD244BioGRID, IntAct26186194 28514442 details
MTORFBXO9DIP23263282 details
MTORCLN6IntAct30177828 details
MTORLRRK2IntAct31046837 details
MTORCD74BioGRID, IntAct30833792 details
MTORP2RY6BioGRID, IntAct30833792 details
MTORTNFSF13BBioGRID, IntAct30833792 details
MTORUNC93B1BioGRID, IntAct30833792 details
MTORSIRT7BioGRID22586326 details
MTORVCPBioGRID23383273 details
MTORMTA2BioGRID22863883 details
MTORSUZ12BioGRID24457600 details
MTORDIAPH1BioGRID26344197 details
MTORTRMT61ABioGRID26344197 details
MTORXPO1BioGRID26673895 details
MTORZUP1BioGRID29576527 details
MTORCFTRBioGRID26618866 details
MTORHIF1ABioGRID27320910 details
MTORZDHHC18BioGRID30658672 details
MTORZDHHC23BioGRID30658672 details
MTORACP3BioGRID28675297 details
MTORBIRC3BioGRID30948266 details
MTORSTAU1BioGRID30948266 details
MTORLMBR1LBioGRID31073040 details
MTORPGRMC1BioGRID31067491 details
MTORTRIM28BioGRID29955894 details
MTORPLEKHA4BioGRID31091453 details
MTORLRRC31BioGRID33005030 details
MTORBCAR1BioGRID33001583 details
MTORCUL4ABioGRID32235678 details
MTORSHMT2BioGRID22658674 details
MTORMOV10BioGRID22658674 details
MTORNXF1BioGRID22658674 details
MTORTRIM25BioGRID29117863 details
MTORVIRMABioGRID29507755 details
MTORMKRN2BioGRID32460013 details