Entity Details

Primary name NF2L1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14494
EntryNameNF2L1_HUMAN
FullNameEndoplasmic reticulum membrane sensor NFE2L1
TaxID9606
Evidenceevidence at protein level
Length772
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesNFE2L1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006783 heme biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0008289 lipid binding
GO:0009653 anatomical structure morphogenesis
GO:0015485 cholesterol binding
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0034599 cellular response to oxidative stress
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0042632 cholesterol homeostasis
GO:0045454 cell redox homeostasis
GO:0046982 protein heterodimerization activity
GO:0055088 lipid homeostasis
GO:0071397 cellular response to cholesterol
GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress
GO:1901329 regulation of odontoblast differentiation

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR004826 Basic leucine zipper domain, Maf-typeDomainDomain
IPR004827 Basic-leucine zipper domainDomainDomain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR029847 Endoplasmic reticulum membrane sensor NFE2L1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB04147 Dodecyldimethylamine N-oxideDrugbanksmall molecule

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
NF2L1_HUMANCD6_HUMANBioGRID, IntAct21988832 details
NF2L1_HUMANKEAP1_HUMANBioGRID, IntAct16687406 21262351 21988832 29255090 30126895 details
NF2L1_HUMANTULP3_HUMANBioGRID, IntAct23414517 details
NF2L1_HUMANMAFG_HUMANBioGRID, HPIDb, HPRD, IntAct, UniProt20102225 23661758 31467278 8932385 9150357 9421508 details
NF2L1_HUMANZHANG_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
NF2L1_HUMANNFE2_HUMANHPIDb20102225 details
NF2L1_HUMANATF7_HUMANHPIDb20102225 details
NF2L1_HUMANATF4_HUMANHPIDb, HPRD11025215 20102225 details
NF2L1_HUMANFOS_HUMANHPIDb20102225 details
NF2L1_HUMANBATF_HUMANHPIDb20102225 details
NF2L1_HUMANMAFB_HUMANHPIDb20102225 details
NF2L1_HUMANNF2L1_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
NF2L1_HUMANPARVA_HUMANBioGRID, IntAct27107012 details
NF2L1_HUMANMAFF_HUMANBioGRID, HPRD, IntAct, UniProt23661758 26186194 28514442 8932385 details
NF2L1_HUMANNF2L3_HUMANBioGRID, UniProt23661758 details
NF2L1_HUMANBACH2_HUMANBioGRID, UniProt23661758 details
NF2L1_HUMANHCFC1_HUMANBioGRID, IntAct20211142 29941490 details
NF2L1_HUMANJUN_HUMANBioGRID, HPRD9872330 details
NF2L1_HUMANCAN1_HUMANBioGRID, HPRD12358155 details
NF2L1_HUMANGSK3B_HUMANBioGRID23623971 details
NF2L1_HUMANFMR1_HUMANIntAct31413325 details
NF2L1_HUMANCEP63_HUMANIntAct31413325 details
NF2L1_HUMANFBXW7_HUMANBioGRID21953459 23623971 details
NF2L1_HUMANFBW1A_HUMANBioGRID25900982 29941490 details
NF2L1_HUMANUBP15_HUMANBioGRID27416755 details
NF2L1_HUMANOGT1_HUMANBioGRID29941490 details
NF2L1_HUMANMAFK_HUMANHPRD12805554 details
NF2L1_HUMANJUNB_HUMANHPRD9872330 details
NF2L1_HUMANJUND_HUMANHPRD9872330 details