Entity Details

Primary name 2A5D_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14738
EntryName2A5D_HUMAN
FullNameSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
TaxID9606
Evidenceevidence at protein level
Length602
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPPP2R5D

GO terms

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GOName
GO:0000159 protein phosphatase type 2A complex
GO:0004721 phosphoprotein phosphatase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0019888 protein phosphatase regulator activity
GO:0031952 regulation of protein autophosphorylation
GO:0035307 positive regulation of protein dephosphorylation
GO:0072542 protein phosphatase activator activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002554 Protein phosphatase 2A, regulatory B subunit, B56FamilyFamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616355 OMIMMental retardation, autosomal dominant 35 (MRD35)A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
2A5D_HUMANNEK1_HUMANIntAct14690447 details
2A5D_HUMANLIPA1_HUMANBioGRID, HPRD, IntAct16189514 26496610 29892012 details
2A5D_HUMAN2A5A_HUMANBioGRID, UniProt16541025 26344197 details
2A5D_HUMANSGO1_HUMANHPRD, MINT, UniProt16541024 16541025 21666598 details
2A5D_HUMANSGO2_HUMANMINT, UniProt16541025 21666598 details
2A5D_HUMAN2AAB_HUMANBioGRID, HPRD, IntAct16541025 17540176 22939629 23555304 26344197 26496610 8703017 details
2A5D_HUMANCHK2_HUMANBioGRID, HPRD, IntAct15380617 details
2A5D_HUMAN2AAA_HUMANBioGRID, IntAct18782753 19156129 19293187 22939629 23443559 23555304 26344197 26496610 27173435 28330616 32296183 unassigned1312 details
2A5D_HUMANM3K3_HUMANMINT16407301 details
2A5D_HUMANDZIP1_HUMANMINT21878643 details
2A5D_HUMANCSK2B_HUMANBioGRID, IntAct23555304 details
2A5D_HUMANBHE40_HUMANIntAct23555304 details
2A5D_HUMANRORG_HUMANBioGRID, IntAct23555304 details
2A5D_HUMANFSD2_HUMANBioGRID, IntAct25416956 details
2A5D_HUMANUSBP1_HUMANBioGRID, IntAct25416956 details
2A5D_HUMANDYDC1_HUMANBioGRID, IntAct32296183 details
2A5D_HUMANHAND2_HUMANBioGRID, HPRD14636580 details
2A5D_HUMANHAND1_HUMANBioGRID, HPRD14636580 details
2A5D_HUMANCLOCK_HUMANBioGRID23555304 details
2A5D_HUMANCRY2_HUMANBioGRID23555304 details
2A5D_HUMANCRY1_HUMANBioGRID23555304 details
2A5D_HUMANKC1E_HUMANBioGRID23555304 details
2A5D_HUMANMPIP3_HUMANDIP, IntAct17110335 18056802 details
2A5D_HUMANPP2AA_HUMANBioGRID, IntAct18782753 19156129 26344197 26496610 27880917 28330616 8703017 details
2A5D_HUMANARL2_HUMANBioGRID12912990 details
2A5D_HUMANGSK3B_HUMANBioGRID22893788 details
2A5D_HUMANPP1A_HUMANBioGRID25487150 details
2A5D_HUMANSTAU1_HUMANBioGRID29395067 details