Entity Details

Primary name TBK1
Entity type gene
Source Source Link

Details

PrimaryID29110
RefseqGeneNG_046906
SymbolTBK1
NameTANK binding kinase 1
Chromosome12
Location12q14.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-03-05
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsTBK1_HUMAN

GO terms

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GOName
GO:0002218 activation of innate immune response
GO:0003676 nucleic acid binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0009615 response to virus
GO:0016032 viral process
GO:0016239 positive regulation of macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019903 protein phosphatase binding
GO:0032479 regulation of type I interferon production
GO:0032480 negative regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0044565 dendritic cell proliferation
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050830 defense response to Gram-positive bacterium
GO:0051219 phosphoprotein binding
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0071345 cellular response to cytokine stimulus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901214 regulation of neuron death
GO:1904417 positive regulation of xenophagy

Diseases

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Interactions

270 interactions

InteractorPartnerSourcesPublicationsLink
TBK1TANKBioGRID, HPRD, IntAct, MINT, UniProt10581243 14743216 17568778 17823124 18307994 21903422 21931555 21988832 23007157 23286385 24488098 25409927 27035970 29251827 29395067 30420664 30561431 31114588 details
TBK1TBK1BioGRID, HPRD, IntAct, MINT14560022 14743216 17599067 19656901 23286385 23453972 25939384 26915459 28871090 31534043 details
TBK1IKBKGBioGRID, HPRD, IntAct14743216 20098747 21903422 23028469 26611359 28514442 30561431 details
TBK1TBKBP1BioGRID, IntAct, MINT, UniProt14743216 17568778 21903422 21931555 23286385 27035970 29395067 30420664 details
TBK1AZI2BioGRID, HPRD, IntAct, UniProt14560022 14743216 17568778 21903422 21931555 23286385 27620379 29251827 29395067 30420664 details
TBK1TRAF2BioGRID, HPRD, IntAct10990461 14743216 20449947 20562859 21903422 23007157 27135603 28514442 29125880 30420664 30561431 32041822 details
TBK1XIAPBioGRID, IntAct16887178 22072751 details
TBK1IRF3BioGRID, HPRD, IntAct, MINT, UniProt12692549 15695821 15841462 16394098 17599067 18583960 18636086 19153231 19656901 20628368 21903422 22072751 22079989 22388039 23028469 24807708 25636800 25803835 28346439 30267576 31534043 32241891 details
TBK1IKBKEBioGRID, IntAct, MINT17599067 21903422 25939384 29251827 30420664 31534043 32298923 details
TBK1IRF7BioGRID, MINT17599067 details
TBK1OPTNBioGRID, IntAct, MINT18307994 20174559 21903422 23414517 25803835 25923723 26365381 27035970 27086836 27538435 27620379 29395067 30327196 31723608 32556086 details
TBK1CYLDBioGRID, MINT18636086 25923723 29755980 details
TBK1DDX3XMINT18583960 details
TBK1PROS1BioGRID, IntAct21988832 details
TBK1STX11BioGRID, IntAct21988832 28514442 details
TBK1STAT6IntAct22000020 details
TBK1CALCOCO2BioGRID, IntAct19820708 21903422 28514442 30309841 details
TBK1MAVSBioGRID, HPRD, IntAct, UniProt16153868 21813773 21903422 23028469 24643253 25636800 28346439 29125880 29743353 32366851 32511263 33372174 details
TBK1AGO2BioGRID, IntAct21903422 details
TBK1TXLNABioGRID, IntAct21903422 28514442 29395067 details
TBK1ATG9ABioGRID, IntAct21903422 details
TBK1CDC42BPGBioGRID, IntAct21903422 details
TBK1MIB1BioGRID, IntAct21903422 31462741 details
TBK1MTPAPBioGRID, IntAct21903422 details
TBK1MIB2BioGRID, IntAct21903422 details
TBK1PTPRDBioGRID, MINT22305495 details
TBK1TRAF3BioGRID, HPRD, IntAct17991829 20174559 22079989 22330071 22792062 22908223 23308279 23717208 23986588 24622840 24763515 26928339 27135603 28049150 29125880 29920243 31404116 32324863 32779804 33372174 33411856 details
TBK1RELABioGRID, HPRD14560022 14743216 15489227 details
TBK1NCK1BioGRID, HPRD7706279 details
TBK1TXLNGBioGRID21903422 29395067 details
TBK1NEDD4BioGRID19953087 details
TBK1MBPBioGRID17599067 details
TBK1PELI1BioGRID21204785 26082489 details
TBK1TRIM27BioGRID16393995 29688809 details
TBK1NFKBIABioGRID, HPRD10783893 20449947 8601309 9721103 details
TBK1APPBioGRID21832049 details
TBK1TRAF3IP2BioGRID22851696 details
TBK1MAP1LC3BBioGRID21617041 details
TBK1AKT1BioGRID21106850 28716898 details
TBK1SOCS3BioGRID25939384 details
TBK1SQSTM1BioGRID25972374 27035970 32835772 details
TBK1PBXIP1BioGRID24488098 details
TBK1SMURF1BioGRID20804422 details
TBK1TRAF6BioGRID28049150 29125880 30530224 details
TBK1RNF128BioGRID27776110 details
TBK1TRAF5BioGRID29125880 details
TBK1TRIM23BioGRID28871090 31189704 details
TBK1SMCR8BioGRID27103069 details
TBK1TRIM21BioGRID29667579 details
TBK1RIPK1BioGRID30420664 details
TBK1RPS6KB1BioGRID28716898 details
TBK1CRTC1BioGRID33411856 details
TBK1CCT8IntAct14743216 details
TBK1HSPA5IntAct14743216 details
TBK1HSPA8IntAct14743216 details
TBK1HSPA9IntAct14743216 details
TBK1RPS5IntAct14743216 details
TBK1RUVBL2BioGRID, IntAct14743216 29395067 details
TBK1CCT5IntAct14743216 details
TBK1RPS18IntAct14743216 details
TBK1ATP5F1AIntAct14743216 details
TBK1TCP1IntAct14743216 details
TBK1CCT7IntAct14743216 details
TBK1RUVBL1IntAct14743216 details
TBK1LGALS3BPBioGRID, IntAct14743216 31404116 details
TBK1CCT3IntAct14743216 details
TBK1CCT6AIntAct14743216 details
TBK1RPL7IntAct14743216 details
TBK1CALM1IntAct14743216 details
TBK1CALM2IntAct14743216 details
TBK1CALM3IntAct14743216 details
TBK1NONOIntAct14743216 details
TBK1TUBBIntAct14743216 details
TBK1TUBB4AIntAct14743216 details
TBK1CCT2IntAct14743216 details
TBK1RPS8IntAct14743216 details
TBK1SFPQIntAct14743216 details
TBK1GAPDHIntAct, MINT14743216 17599067 details
TBK1TUBA3DIntAct14743216 details
TBK1TUBA3CIntAct14743216 details
TBK1RPL11IntAct14743216 details
TBK1RPL13IntAct14743216 details
TBK1LDHBIntAct14743216 details
TBK1HNRNPMIntAct14743216 details
TBK1CCT4IntAct14743216 details
TBK1HSP90AB1HPRD, IntAct14743216 22939624 details
TBK1HSP90AA1BioGRID, HPRD, IntAct14743216 16394098 20628368 22939624 details
TBK1UBCMINT18636086 details
TBK1RB1CC1BioGRID, IntAct20562859 30853401 details
TBK1TICAM1BioGRID, DIP, HPRD, IntAct, UniProt14530355 15841462 19416887 19656901 21903422 25736436 28049150 28747347 31511519 details
TBK1IKBKBHPRD, IntAct14560022 21782231 details
TBK1STING1BioGRID, DIP, HPIDb, IntAct18724357 19416887 19433799 21074459 21903422 22745133 23542348 24622840 28346439 28763789 29899553 30943264 31534043 32383759 33086059 33139700 details
TBK1MAP3K14InnateDB23023393 details
TBK1WHRNBioGRID, IntAct27173435 unassigned1312 details
TBK1RIOK3UniProt24807708 details
TBK1ICOSBioGRID, IntAct27135603 details
TBK1TTC4IntAct29251827 details
TBK1TNFAIP3BioGRID, IntAct15661910 19615732 21885437 30561431 details
TBK1TNIP1BioGRID, IntAct21885437 30561431 details
TBK1UBBIntAct24622840 details
TBK1TNFBioGRID15485837 27307491 27545878 30420664 details
TBK1TLR4BioGRID21911421 details
TBK1TLR9BioGRID21911421 details
TBK1TLR3BioGRID21911421 27810922 details
TBK1NCOA2BioGRID16051665 details
TBK1NLRP4BioGRID22388039 26407194 details
TBK1DTX4BioGRID22388039 details
TBK1TAX1BP1BioGRID21885437 28877469 31723608 details
TBK1TRAIPBioGRID22945920 details
TBK1SRCBioGRID19419966 details
TBK1RNF11BioGRID23308279 details
TBK1YWHAEBioGRID20462248 details
TBK1TOMM70BioGRID20628368 details
TBK1DDX58BioGRID23950712 details
TBK1SYKBioGRID23962979 details
TBK1EXOC2BioGRID24056301 28716898 details
TBK1IFIT3BioGRID21813773 details
TBK1USP2BioGRID25070846 details
TBK1ESR1BioGRID26186972 details
TBK1TRIM26BioGRID26611359 details
TBK1DYRK2BioGRID26407194 details
TBK1TRIM14BioGRID24379373 details
TBK1CTNNBL1BioGRID27035970 details
TBK1TRIM9BioGRID26915459 details
TBK1GSK3BBioGRID26915459 details
TBK1HERPUD1BioGRID28954889 details
TBK1YAP1BioGRID28346439 details
TBK1WDR48BioGRID29138248 details
TBK1USP1BioGRID29138248 details
TBK1ZC3H12ABioGRID29920243 details
TBK1PRKNBioGRID29903906 details
TBK1TNFRSF1ABioGRID30420664 details
TBK1RNF31BioGRID30420664 details
TBK1MTORBioGRID28716898 details
TBK1RPTORBioGRID28716898 details
TBK1EXOC7BioGRID28716898 details
TBK1TSC2BioGRID28716898 details
TBK1ULK1BioGRID28716898 details
TBK1RRAGDBioGRID28716898 details
TBK1LGALS3BioGRID30404831 details
TBK1RNF144BBioGRID31509299 details
TBK1LZTS2BioGRID29395067 details
TBK1MEX3BBioGRID29395067 details
TBK1PATL1BioGRID29395067 details
TBK1PRPF19BioGRID29395067 details
TBK1OBI1BioGRID29395067 details
TBK1SAMD4BBioGRID29395067 details
TBK1CDK5RAP2BioGRID29395067 details
TBK1CNTRLBioGRID29395067 details
TBK1DNAJA1BioGRID29395067 details
TBK1DNAJA2BioGRID29395067 details
TBK1DPCDBioGRID29395067 details
TBK1GOLGA3BioGRID29395067 details
TBK1TNRC6ABioGRID29395067 details
TBK1TNRC6BBioGRID29395067 details
TBK1TNRC6CBioGRID29395067 details
TBK1ZFP36BioGRID29395067 details
TBK1DCP1ABioGRID29395067 details
TBK1MARF1BioGRID29395067 details
TBK1RNF214BioGRID29395067 details
TBK1SIRT2BioGRID29395067 details
TBK1TFGBioGRID33411856 details
TBK1NACC1BioGRID31235549 details
TBK1PSMF1BioGRID31114588 details
TBK1SEC16ABioGRID31114588 details
TBK1UBE2SBioGRID32814047 details
TBK1USP15BioGRID32814047 details
TBK1IRF5HPRD15556946 15695821 details
TBK1SIKE1HPRD16281057 details
TBK1CDC37BioGRID, HPRD, IntAct14743216 details
TBK1TNIP3IntAct19615732 details
TBK1SUMO1MINT21212807 details
TBK1RBBP5BioGRID, IntAct21903422 details
TBK1FXR2BioGRID, IntAct21903422 details
TBK1HMMRBioGRID, IntAct21903422 details
TBK1FMR1BioGRID, IntAct21903422 details
TBK1LETM1BioGRID, IntAct21903422 details
TBK1ANKRD28BioGRID, IntAct14743216 24255178 details
TBK1PKMIntAct24606918 details
TBK1EGLN3BioGRID, IntAct26972000 details
TBK1RARAIntAct25303530 details
TBK1SCLT1BioGRID, IntAct26638075 details
TBK1ODF2BioGRID, IntAct26638075 details
TBK1CEP128BioGRID, IntAct26638075 details
TBK1OFD1BioGRID, IntAct26638075 details
TBK1CEP152BioGRID, IntAct26638075 details
TBK1STILBioGRID, IntAct26638075 details
TBK1CEP135BioGRID, IntAct26638075 34079125 details
TBK1SASS6BioGRID, IntAct26638075 details
TBK1CNTROBBioGRID, IntAct26638075 details
TBK1CEP63BioGRID, IntAct26638075 details
TBK1CEP44BioGRID, IntAct26638075 details
TBK1SSX2IPBioGRID, IntAct26638075 details
TBK1NINLBioGRID, IntAct26638075 details
TBK1PLK1BioGRID, IntAct25659891 28514442 details
TBK1STX12BioGRID, IntAct26186194 28514442 details
TBK1APBA3BioGRID, IntAct26186194 28514442 details
TBK1STX3BioGRID, IntAct26186194 28514442 details
TBK1HIF1ANBioGRID, IntAct28514442 details
TBK1STX19BioGRID, IntAct26186194 28514442 details
TBK1TRIM10BioGRID, IntAct26186194 28514442 details
TBK1TRAF1BioGRID, IntAct25996949 28514442 details
TBK1TXLNBBioGRID, IntAct28514442 details
TBK1BBOX1BioGRID, IntAct26186194 28514442 details
TBK1CAMK2DIntAct29426014 details
TBK1NUMA1IntAct29251827 details
TBK1NEDD9IntAct29251827 details
TBK1ABRIntAct29251827 details
TBK1MKI67IntAct29251827 details
TBK1OSBPL3IntAct29251827 details
TBK1MAP3K4IntAct29251827 details
TBK1FMNL1IntAct29251827 details
TBK1FOXJ3IntAct29251827 details
TBK1UBR5IntAct29251827 details
TBK1TNIP2BioGRID, IntAct27609421 30561431 details
TBK1MED4BioGRID, MINT25281560 details
TBK1TRAF3IP3BioGRID, MINT32366851 details
TBK1C9orf72MINT27103069 details
TBK1NFKB1BioGRID14743216 details
TBK1BTRCBioGRID14743216 details
TBK1RELBioGRID14743216 details
TBK1CUL1BioGRID14743216 details
TBK1PPP6R2BioGRID14743216 details
TBK1PPP6R1BioGRID14743216 details
TBK1NFKB2BioGRID14743216 details
TBK1PPP6CBioGRID14743216 details
TBK1SKP1BioGRID14743216 details
TBK1HERC2BioGRID22261722 details
TBK1LATS2BioGRID24255178 details
TBK1EGFRBioGRID24797263 details
TBK1CCDC8BioGRID24711643 details
TBK1NTRK1BioGRID25921289 details
TBK1XPO1BioGRID26673895 details
TBK1MCM2BioGRID25963833 details
TBK1CLEC14ABioGRID23979707 details
TBK1BMPR1ABioGRID27684187 details
TBK1ESR2BioGRID29509190 details
TBK1RNF123BioGRID29676528 details
TBK1ATG16L1BioGRID30196744 details
TBK1HDAC2BioGRID30737378 details
TBK1BICD1BioGRID28718761 details
TBK1BICD2BioGRID28718761 details
TBK1HOOK1BioGRID28718761 details
TBK1NINBioGRID28718761 details
TBK1STAU1BioGRID30948266 details
TBK1LMBR1LBioGRID31073040 details
TBK1PLEKHA4BioGRID31091453 details
TBK1NHLRC2BioGRID30397336 details
TBK1HTRA2BioGRID31617661 details
TBK1IMMP1LBioGRID31617661 details
TBK1IMMP2LBioGRID31617661 details
TBK1CNOT9BioGRID29395067 details
TBK1GARRE1BioGRID29395067 details
TBK1BRD1BioGRID31753913 details
TBK1PHIPBioGRID31753913 details
TBK1EIF4BBioGRID32298923 details
TBK1LRRC10BBioGRID32298923 details
TBK1ACBD5BioGRID34079125 details
TBK1AMOTBioGRID34079125 details
TBK1BORCS6BioGRID34079125 details
TBK1DCTN2BioGRID34079125 details
TBK1KRT18BioGRID34079125 details
TBK1KRT8BioGRID34079125 details
TBK1NDC80BioGRID34079125 details
TBK1POLR2CBioGRID34079125 details
TBK1PRPHBioGRID34079125 details
TBK1PXNBioGRID34079125 details
TBK1STX4BioGRID34079125 details
TBK1SYNE3BioGRID34079125 details
TBK1HNRNPLBioGRID28611215 details