Entity Details

Primary name APAF1
Entity type gene
Source Source Link

Details

PrimaryID317
RefseqGeneNG_029094
SymbolAPAF1
Nameapoptotic peptidase activating factor 1
Chromosome12
Location12q23.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-07-30
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsAPAF_HUMAN

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0001666 response to hypoxia
GO:0001822 kidney development
GO:0001843 neural tube closure
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007399 nervous system development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010659 cardiac muscle cell apoptotic process
GO:0030154 cell differentiation
GO:0030900 forebrain development
GO:0031072 heat shock protein binding
GO:0032991 protein-containing complex
GO:0034774 secretory granule lumen
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043293 apoptosome
GO:0043312 neutrophil degranulation
GO:0043531 ADP binding
GO:0051402 neuron apoptotic process
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070062 extracellular exosome
GO:0070317 negative regulation of G0 to G1 transition
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072432 response to G1 DNA damage checkpoint signaling
GO:0097193 intrinsic apoptotic signaling pathway
GO:1902510 regulation of apoptotic DNA fragmentation
GO:1904813 ficolin-1-rich granule lumen
GO:2001235 positive regulation of apoptotic signaling pathway

Diseases

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Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
APAF1CASP9BioGRID, DIP, HPRD, IntAct, MINT10206961 10376594 11113115 11242052 15262985 16979168 19494828 19698783 20462491 20829884 21060833 21827945 27197231 27476169 28716524 9390557 9488720 9539746 9837928 9922454 details
APAF1AVENBioGRID, HPRD, MINT10949025 details
APAF1CASP3HPRD, IntAct, MINT11550094 21827945 details
APAF1PPP1CABioGRID, HPRD, IntAct17274640 details
APAF1APIPBioGRID, HPRD15262985 details
APAF1HSPA4BioGRID10934467 22143029 31577950 details
APAF1HSP90AA1BioGRID10934467 15001356 details
APAF1BCL2L1BioGRID, HPRD12963020 9488720 9539746 details
APAF1TOP1BioGRID12549820 details
APAF1BCL2L10HPRD10486928 9829980 9878060 details
APAF1HSPA1AHPRD, MINT10934467 details
APAF1HSPA1BMINT10934467 details
APAF1CYCSBioGRID, HPRD, IntAct10206961 12147322 16979168 9267021 details
APAF1YWHAEMINT22246185 details
APAF1NLRP1BioGRID, HPRD11113115 17418785 details
APAF1CASP4BioGRID, HPRD9539746 details
APAF1CASP8BioGRID, HPRD9539746 details
APAF1TRIAP1BioGRID, HPRD15735003 details
APAF1XIAPBioGRID11242052 19698783 details
APAF1HSP90B1BioGRID25737303 details
APAF1HIP1BioGRID, HPRD16979168 details
APAF1CUL4BBioGRID31329620 details
APAF1SQSTM1BioGRID31329620 details
APAF1FEM1BHPRD10764728 details
APAF1FASHPRD9267021 details
APAF1IQCNBioGRID, IntAct28514442 details
APAF1ENDOVBioGRID, IntAct26186194 28514442 details
APAF1PTGES3LIntAct28514442 details
APAF1PTGES3L-AARSD1IntAct28514442 details
APAF1AARSD1BioGRID, IntAct28514442 details
APAF1LYPD4BioGRID, IntAct28514442 details
APAF1WDFY3BioGRID, IntAct28514442 details
APAF1DEF8BioGRID, IntAct28514442 details
APAF1LGALS7BioGRID, IntAct28514442 details
APAF1LGALS7BIntAct28514442 details
APAF1OMDBioGRID, IntAct28514442 details
APAF1CRYBA4BioGRID, IntAct28514442 details
APAF1RSL1D1BioGRID, IntAct30021884 details
APAF1H3-4BioGRID, IntAct30021884 details
APAF1TRIM28BioGRID29955894 details
APAF1CCDC8BioGRID31343991 details
APAF1DNAJC7BioGRID33957083 details
APAF1TP53BioGRID32807901 details
APAF1ELAVL1BioGRID19322201 details
APAF1SHMT2BioGRID22658674 details
APAF1APEX1BioGRID28986522 details