Entity Details

Primary name CXCL8
Entity type gene
Source Source Link

Details

PrimaryID3576
RefseqGeneNG_029889
SymbolCXCL8
NameC-X-C motif chemokine ligand 8
Chromosome4
Location4q13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-12
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsIL8_HUMAN

GO terms

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GOName
GO:0001525 angiogenesis
GO:0002237 response to molecule of bacterial origin
GO:0005153 interleukin-8 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008009 chemokine activity
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0019722 calcium-mediated signaling
GO:0030155 regulation of cell adhesion
GO:0030593 neutrophil chemotaxis
GO:0031328 positive regulation of cellular biosynthetic process
GO:0031623 receptor internalization
GO:0031640 killing of cells of other organism
GO:0034976 response to endoplasmic reticulum stress
GO:0035556 intracellular signal transduction
GO:0036499 PERK-mediated unfolded protein response
GO:0042119 neutrophil activation
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045236 CXCR chemokine receptor binding
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0048566 embryonic digestive tract development
GO:0050930 induction of positive chemotaxis
GO:0060354 negative regulation of cell adhesion molecule production
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0090023 positive regulation of neutrophil chemotaxis
GO:2000535 regulation of entry of bacterium into host cell

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
CXCL8ARFGAP3BioGRID, IntAct21988832 details
CXCL8POMGNT1BioGRID, IntAct21988832 details
CXCL8SGTABioGRID, IntAct21988832 details
CXCL8BAG6BioGRID, IntAct21988832 details
CXCL8CXCR2BioGRID, DIP, HPRD, IntAct22904195 23597562 8626516 8702798 9464567 details
CXCL8TNFAIP6IntAct24501198 details
CXCL8PF4bhf-ucl, BioGRID, HPRD12586630 15531763 28381538 details
CXCL8CCL8bhf-ucl, BioGRID28381538 details
CXCL8CCL2bhf-ucl, BioGRID28381538 details
CXCL8NLRP12I2D32226298 details
CXCL8SDC1BioGRID, HPRD12902511 details
CXCL8CXCL8BioGRID, HPRD10368283 10707023 1988949 20047188 2184886 2681204 8077676 9141135 details
CXCL8CCL5BioGRID11509627 details
CXCL8EP300BioGRID11940655 details
CXCL8ERBB2BioGRID7907421 details
CXCL8ACKR1HPRD17416748 9921412 details
CXCL8CTSLHPRD12818188 details
CXCL8MMP9HPRD11023497 details
CXCL8WASF1HPRD16862120 details
CXCL8IL12AHPRD16862120 details
CXCL8GNAI2HPRD8662698 details
CXCL8CXCR1HPRD1840701 details
CXCL8CCL4HPRD8077676 details
CXCL8RELAIntAct17362989 18045535 18316612 19064995 24634218 details
CXCL8RPS3IntAct18045535 details
CXCL8MTDHIntAct18316612 details
CXCL8CREBBPIntAct18316612 25314079 details
CXCL8SNAI1IntAct25314079 details
CXCL8KLF6IntAct24634218 details
CXCL8JUNIntAct19064995 details
CXCL8CEBPBIntAct19064995 details
CXCL8ARXIntAct33179750 details
CXCL8ALX4IntAct33179750 details
CXCL8ATOH1IntAct33179750 details
CXCL8BHLHE22IntAct33179750 details
CXCL8ERFIntAct33179750 details
CXCL8EVX2IntAct33179750 details
CXCL8HOXA1IntAct33179750 details
CXCL8HOXA2IntAct33179750 details
CXCL8ZNF710IntAct33179750 details
CXCL8ZDHHC7IntAct33179750 details
CXCL8TFAP2EIntAct33179750 details
CXCL8TFAP2BIntAct33179750 details
CXCL8TFAP2AIntAct33179750 details
CXCL8RELIntAct33179750 details
CXCL8NFIL3IntAct33179750 details
CXCL8MEOX1IntAct33179750 details
CXCL8MAFGIntAct33179750 details
CXCL8HOXC5IntAct33179750 details
CXCL8HOXB4IntAct33179750 details
CXCL8ZNF598BioGRID30917308 details
CXCL8ZFP36BioGRID30917308 details