Entity Details

Primary name SMAD7
Entity type gene
Source Source Link

Details

PrimaryID4092
RefseqGeneNG_023330
SymbolSMAD7
NameSMAD family member 7
Chromosome18
Location18q21.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-12
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsSMAD7_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0001650 fibrillar center
GO:0001657 ureteric bud development
GO:0002725 negative regulation of T cell cytokine production
GO:0003677 DNA binding
GO:0005518 collagen binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008013 beta-catenin binding
GO:0009653 anatomical structure morphogenesis
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0016579 protein deubiquitination
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925 regulation of activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034333 adherens junction assembly
GO:0034616 response to laminar fluid shear stress
GO:0034629 cellular protein-containing complex localization
GO:0034713 type I transforming growth factor beta receptor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048185 activin binding
GO:0048844 artery morphogenesis
GO:0050821 protein stabilization
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055117 regulation of cardiac muscle contraction
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0070411 I-SMAD binding
GO:0071144 heteromeric SMAD protein complex
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0140416 transcription regulator inhibitor activity
GO:1902731 negative regulation of chondrocyte proliferation
GO:1903043 positive regulation of chondrocyte hypertrophy
GO:1990830 cellular response to leukemia inhibitory factor
GO:2000317 negative regulation of T-helper 17 type immune response
GO:2000320 negative regulation of T-helper 17 cell differentiation

Diseases

Show/Hide Table

Interactions

106 interactions

InteractorPartnerSourcesPublicationsLink
SMAD7SMURF2BioGRID, DIP, HPRD, MINT11163210 14722617 15221015 15231748 16061177 16641086 17719543 18448069 20937913 22624557 22773947 22921829 23973329 26435193 26679521 27292644 28292929 29235476 32283253 details
SMAD7PIAS1BioGRID, HPRD, MINT15231748 details
SMAD7PIAS4BioGRID, HPRD, MINT12815042 15231748 details
SMAD7XRCC6BioGRID, HPRD, MINT15231748 details
SMAD7KDM2ABioGRID, HPRD, MINT15231748 details
SMAD7HEYLBioGRID, HPRD, MINT15231748 details
SMAD7CXXC5BioGRID, HPRD, MINT15231748 details
SMAD7SOX7BioGRID, HPRD, MINT15231748 details
SMAD7ZNF107BioGRID, HPRD, MINT15231748 details
SMAD7TTF2BioGRID, HPRD, MINT15231748 details
SMAD7MYOD1BioGRID, HPRD, MINT15231748 details
SMAD7SOX5BioGRID, HPRD, MINT15231748 details
SMAD7ASH1LBioGRID, HPRD, MINT15231748 details
SMAD7ZBTB11BioGRID, HPRD, MINT15231748 details
SMAD7SOX13BioGRID, HPRD, MINT15231748 details
SMAD7MRTFBBioGRID, MINT15231748 details
SMAD7TTF1BioGRID, HPRD, MINT15231748 details
SMAD7COPS5BioGRID, IntAct14993265 details
SMAD7WWP2BioGRID, I2D21258410 22773947 31546607 details
SMAD7SIRT1BioGRID, UniProt17098745 details
SMAD7FKBP1Abhf-ucl, BioGRID16720724 details
SMAD7YAP1BioGRID, DIP, HPRD, MINT12118366 22921829 25283809 details
SMAD7EP300BioGRID, HPRD, IntAct12408818 25303530 details
SMAD7SMAD4BioGRID, IntAct15128733 15817471 17438144 19032343 26555259 details
SMAD7SMURF1BioGRID, DIP, HPRD11278251 12151385 12519765 14722617 15221015 16720724 20937913 22152476 22773947 22921829 23959799 24700460 27292644 details
SMAD7NEDD4LBioGRID, DIP22773947 22921829 details
SMAD7TGFBR1BioGRID, HPRD10757800 11163210 12151385 14657019 14722617 15148321 15359284 15946939 16027725 17314099 19758997 20663871 21791611 22624557 23027871 25149540 31746425 9215638 9335507 details
SMAD7RNF111BioGRID, HPRD14657019 23530056 27292644 details
SMAD7DVL1BioGRID, HPRD12650946 details
SMAD7ERBINBioGRID, HPRD12650946 details
SMAD7STAMBPBioGRID, HPRD11483516 details
SMAD7SMAD6BioGRID, HPRD26555259 9256479 details
SMAD7UCHL5BioGRID16027725 details
SMAD7HDAC1BioGRID15831498 15831516 details
SMAD7SMAD2BioGRID17438144 26555259 details
SMAD7ZEB1BioGRID20514018 details
SMAD7UBE2L3BioGRID16061177 details
SMAD7TGFB1I1BioGRID18762808 details
SMAD7PPP1R15ABioGRID14718519 details
SMAD7CBLBioGRID26055326 details
SMAD7PARD3BioGRID, HPRD12650946 details
SMAD7AXIN2BioGRID24584437 27292644 details
SMAD7SMAD3BioGRID26555259 details
SMAD7SETD7BioGRID27292644 details
SMAD7OTUD1BioGRID29235476 details
SMAD7RLIMBioGRID29235476 details
SMAD7ZBTB44HPRD15231748 details
SMAD7MBD1HPRD15231748 details
SMAD7AXIN1BioGRID, HPRD, MINT16601693 18593713 details
SMAD7ACVR1Bbhf-ucl, BioGRID, HPRD12023024 16720724 20663871 details
SMAD7HDAC3BioGRID, IntAct15831498 15831516 19032343 details
SMAD7RNF165DIP23610558 details
SMAD7BMPR1ABioGRID15148321 20663871 details
SMAD7CTNNB1BioGRID, HPRD15684397 18593713 details
SMAD7LEF1BioGRID15684397 15750622 details
SMAD7MAPK14BioGRID, HPRD12589052 17172861 details
SMAD7MAP2K3BioGRID12589052 details
SMAD7MAP2K6BioGRID, HPRD12589052 details
SMAD7MAP3K7BioGRID, HPRD12589052 details
SMAD7TAB1BioGRID, HPRD11737269 12589052 details
SMAD7TGFBR2BioGRID, HPRD11163210 25149540 9335507 details
SMAD7AKT1BioGRID, HPRD16362038 details
SMAD7STRAPBioGRID, HPRD10757800 17314099 details
SMAD7KAT2BBioGRID16285943 details
SMAD7ITCHBioGRID15946939 22773947 28400336 details
SMAD7HDAC2BioGRID15831498 15831516 details
SMAD7HDAC5BioGRID15831498 15831516 details
SMAD7HDAC6BioGRID15831498 15831516 details
SMAD7NEDD4BioGRID15496141 22773947 details
SMAD7SRFBioGRID16690609 details
SMAD7WWP1BioGRID15221015 15359284 22773947 details
SMAD7TSC22D1BioGRID21791611 details
SMAD7USP11BioGRID22773947 24850914 details
SMAD7USP15BioGRID22344298 30980801 details
SMAD7TAB2BioGRID17384642 details
SMAD7TAB3BioGRID17384642 details
SMAD7TOLLIPBioGRID23027871 details
SMAD7TP53BioGRID17172861 details
SMAD7ATMBioGRID17172861 details
SMAD7BAMBIBioGRID19758997 details
SMAD7CDH1BioGRID18593713 details
SMAD7BMPR2BioGRID20663871 details
SMAD7ACVR1BioGRID20663871 details
SMAD7ACVR2BBioGRID20663871 details
SMAD7UBE2OBioGRID23455153 details
SMAD7MYCBioGRID24259667 details
SMAD7SKP2BioGRID24259667 details
SMAD7TCF7L2BioGRID15684397 details
SMAD7NR4A1BioGRID24584437 details
SMAD7SMAD1BioGRID26555259 details
SMAD7SMAD9BioGRID26555259 details
SMAD7CYLDBioGRID30315770 details
SMAD7TBR1BioGRID30980801 details
SMAD7TRIM37BioGRID32916597 details
SMAD7SMAD7HPRD12589052 details
SMAD7HAT1HPRD12408818 details
SMAD7STAMBPL1HPRD14728725 details
SMAD7BMPR1BHPRD15761153 details
SMAD7SASH3HPRD15761153 details
SMAD7CUL4ABioGRID30945288 details
SMAD7CUL4BBioGRID30945288 details
SMAD7MED24BioGRID27703004 details
SMAD7SKIIntAct15128733 19032343 details
SMAD7PRMT5IntAct19032343 details
SMAD7TBL1XR1IntAct19032343 details
SMAD7TNIP2BioGRID27609421 details