Entity Details

Primary name AFDN
Entity type gene
Source Source Link

Details

PrimaryID4301
RefseqGeneNG_029689
SymbolAFDN
Nameafadin, adherens junction formation factor
Chromosome6
Location6q27
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsAFAD_HUMAN

GO terms

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GOName
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008022 protein C-terminus binding
GO:0010628 positive regulation of gene expression
GO:0016607 nuclear speck
GO:0022409 positive regulation of cell-cell adhesion
GO:0030054 cell junction
GO:0030336 negative regulation of cell migration
GO:0031267 small GTPase binding
GO:0032880 regulation of protein localization
GO:0034332 adherens junction organization
GO:0043547 positive regulation of GTPase activity
GO:0044291 cell-cell contact zone
GO:0044331 cell-cell adhesion mediated by cadherin
GO:0045296 cadherin binding
GO:0046930 pore complex
GO:0046931 pore complex assembly
GO:0050839 cell adhesion molecule binding
GO:0051015 actin filament binding
GO:0061951 establishment of protein localization to plasma membrane
GO:0070160 tight junction
GO:0070830 bicellular tight junction assembly
GO:0090557 establishment of endothelial intestinal barrier
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin

Diseases

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Interactions

269 interactions

InteractorPartnerSourcesPublicationsLink
AFDNMRASMINT10446149 details
AFDNLMO2BioGRID, MINT12067721 details
AFDNRIT1BioGRID, IntAct10545207 details
AFDNNECTIN1BioGRID, MINT10225955 15811349 details
AFDNNECTIN2BioGRID, IntAct, MINT10225955 10617658 15811349 23750010 34079125 details
AFDNEPHA7BioGRID, MINT34079125 9707552 details
AFDNEPHB2BioGRID, MINT9707552 details
AFDNEPHB6BioGRID, MINT9707552 details
AFDNEPHB3BioGRID, MINT9707552 details
AFDNNECTIN3BioGRID, MINT10744716 11024295 15811349 details
AFDNNECTIN4MINT15811349 details
AFDNSMAD2BioGRID, MINT15231748 details
AFDNSRCMINT17491594 details
AFDNBCRBioGRID, MINT12808105 17491594 34079125 details
AFDNTJP1BioGRID, IntAct10334923 23750010 34079125 details
AFDNCTNNA1BioGRID, IntAct11907041 23750010 34079125 details
AFDNRAP1GAPBioGRID12590145 details
AFDNPFN1BioGRID10922060 details
AFDNSSX2IPBioGRID12446711 details
AFDNUSP9XBioGRID10620020 9722616 details
AFDNHRASBioGRID10334923 10922060 8557659 details
AFDNRAP1ABioGRID10922060 details
AFDNNRXN1BioGRID9707552 details
AFDNNRXN2BioGRID9707552 details
AFDNNRXN3BioGRID9707552 details
AFDNJAG1BioGRID9707552 details
AFDNSORBS1BioGRID10085297 34079125 details
AFDNRIN1BioGRID10545207 details
AFDNSORBS2BioGRID10521485 details
AFDNF11RBioGRID10856295 details
AFDNRRAS2BioGRID11788587 details
AFDNPRKNBioGRID23393160 details
AFDNYWHAZMINT15161933 details
AFDNDBN1IntAct23750010 details
AFDNDCLK1BioGRID, IntAct27173435 unassigned1312 details
AFDNSIPA1L1BioGRID, IntAct27173435 34079125 unassigned1312 details
AFDNRAB3IPBioGRID, IntAct27173435 unassigned1312 details
AFDNDENND1ABioGRID, IntAct27173435 unassigned1312 details
AFDNKSR1BioGRID, IntAct27173435 unassigned1312 details
AFDNANKRD34ABioGRID, IntAct27173435 unassigned1312 details
AFDNSH3PXD2ABioGRID, IntAct27173435 unassigned1312 details
AFDNTBC1D25BioGRID, IntAct27173435 unassigned1312 details
AFDNZNF638BioGRID, IntAct27173435 unassigned1312 details
AFDNCDK16BioGRID, IntAct27173435 unassigned1312 details
AFDNCDC25BBioGRID, IntAct27173435 unassigned1312 details
AFDNSRGAP2BioGRID, IntAct27173435 unassigned1312 details
AFDNEIF4E2BioGRID, IntAct27173435 unassigned1312 details
AFDNFAM53CBioGRID, IntAct27173435 unassigned1312 details
AFDNKCTD3BioGRID, IntAct27173435 unassigned1312 details
AFDNAGAP1BioGRID, IntAct27173435 unassigned1312 details
AFDNZBTB21BioGRID, IntAct27173435 unassigned1312 details
AFDNUSP21BioGRID, IntAct27173435 unassigned1312 details
AFDNLIMA1BioGRID, IntAct27173435 unassigned1312 details
AFDNSYDE1BioGRID, IntAct27173435 unassigned1312 details
AFDNFAM110BBioGRID, IntAct27173435 unassigned1312 details
AFDNSRSF12BioGRID, IntAct27173435 unassigned1312 details
AFDNMAGI1BioGRID, IntAct27173435 34079125 unassigned1312 details
AFDNTESK2BioGRID, IntAct27173435 unassigned1312 details
AFDNFAM110ABioGRID, IntAct27173435 unassigned1312 details
AFDNKIF13BBioGRID, IntAct27173435 unassigned1312 details
AFDNLRFN1BioGRID, IntAct27173435 unassigned1312 details
AFDNCBY1BioGRID, IntAct27173435 unassigned1312 details
AFDNYWHAQBioGRID17353931 23444366 details
AFDNNRASBioGRID12808105 details
AFDNKMT2ABioGRID16239140 details
AFDNMEN1BioGRID16239140 details
AFDNYWHAEBioGRID17979178 details
AFDNGRB2BioGRID21706016 details
AFDNRNF146BioGRID27521426 details
AFDNHDAC6BioGRID31264358 details
AFDNYWHAGBioGRID, IntAct, MINT15324660 17353931 28514442 details
AFDNYWHABBioGRID, IntAct, MINT15324660 17353931 28514442 details
AFDNARRB2BioGRID, IntAct17620599 details
AFDNYWHAHIntAct17979178 28514442 details
AFDNVCAM1BioGRID, IntAct19738201 22623428 details
AFDNFN1BioGRID, IntAct19738201 details
AFDNJUNMINT25609649 details
AFDNCAPZA2BioGRID, IntAct26496610 details
AFDNBCAR1bhf-ucl28007913 details
AFDNNCK2BioGRID, IntAct26186194 28514442 details
AFDNID2BioGRID, IntAct28514442 details
AFDNKLHDC3BioGRID, IntAct28514442 details
AFDNFGL1BioGRID, IntAct26186194 28514442 details
AFDNHIF1ANBioGRID, IntAct28514442 details
AFDNCPNE2BioGRID, IntAct28514442 details
AFDNPRICKLE3BioGRID, IntAct28514442 details
AFDNMTUS2BioGRID, IntAct28514442 details
AFDNMRPS11BioGRID, IntAct28514442 details
AFDNTMEM184ABioGRID, IntAct28514442 details
AFDNCYP1A1BioGRID, IntAct26186194 28514442 details
AFDNFGF9BioGRID, IntAct28514442 details
AFDNFUOMBioGRID, IntAct28514442 details
AFDNCEPT1BioGRID, IntAct28514442 details
AFDNEZRIntAct29568061 details
AFDNPRNPBioGRID, UniProt29791485 details
AFDNESR1BioGRID, IntAct31527615 details
AFDNSIRT7BioGRID22586326 details
AFDNHNRNPA1BioGRID22446626 details
AFDNITGA4BioGRID22623428 details
AFDNLATS2BioGRID24255178 34079125 details
AFDNLGR4BioGRID24639526 details
AFDNCUL7BioGRID24711643 details
AFDNOBSL1BioGRID24711643 details
AFDNCCDC8BioGRID24711643 details
AFDNNAA38BioGRID26344197 details
AFDNNOTCH2BioGRID26344197 34079125 details
AFDNNR2C2BioGRID26344197 details
AFDNNTRK1BioGRID25921289 details
AFDNNUP35BioGRID24927568 details
AFDNCDH1BioGRID25468996 details
AFDNSOCS6BioGRID28883622 details
AFDNRNF4BioGRID29180619 details
AFDNARIH1BioGRID27565346 details
AFDNMYCBioGRID29467282 details
AFDNKRASBioGRID30194290 34079125 details
AFDNDCAF15BioGRID31452512 details
AFDNBICD2BioGRID28718761 details
AFDNPTPRUBioGRID28675297 details
AFDNBIRC3BioGRID30948266 details
AFDNLZTS2BioGRID29395067 34079125 details
AFDNSEC62BioGRID32788342 details
AFDNCUL4ABioGRID32235678 details
AFDNCAV1BioGRID34079125 details
AFDNCTNNB1BioGRID34079125 details
AFDNLYNBioGRID34079125 details
AFDNMARCKSBioGRID34079125 details
AFDNADGRL2BioGRID34079125 details
AFDNAMOTL1BioGRID34079125 details
AFDNANKRD26BioGRID34079125 details
AFDNAPCBioGRID34079125 details
AFDNARHGAP21BioGRID34079125 details
AFDNARHGAP29BioGRID34079125 details
AFDNARHGAP32BioGRID34079125 details
AFDNARHGAP39BioGRID34079125 details
AFDNATP2B1BioGRID34079125 details
AFDNCCDC85CBioGRID34079125 details
AFDNCCDC88ABioGRID34079125 details
AFDNCCDC88CBioGRID34079125 details
AFDNCDC42BPABioGRID34079125 details
AFDNCDCA3BioGRID34079125 details
AFDNCEP131BioGRID34079125 details
AFDNCEP89BioGRID34079125 details
AFDNCGNBioGRID34079125 details
AFDNCGNL1BioGRID34079125 details
AFDNCSBioGRID34079125 details
AFDNCTNND1BioGRID34079125 details
AFDNCXADRBioGRID34079125 details
AFDNDEPDC1BBioGRID34079125 details
AFDNDLG1BioGRID34079125 details
AFDNDLG5BioGRID34079125 details
AFDNDSC2BioGRID34079125 details
AFDNDSG2BioGRID34079125 details
AFDNDSTBioGRID34079125 details
AFDNEFNB2BioGRID34079125 details
AFDNEFR3ABioGRID34079125 details
AFDNEFR3BBioGRID34079125 details
AFDNEGFRBioGRID34079125 details
AFDNEPB41L5BioGRID34079125 details
AFDNEPHA2BioGRID34079125 details
AFDNERBINBioGRID34079125 details
AFDNFAM171A1BioGRID34079125 details
AFDNFAM171A2BioGRID34079125 details
AFDNFAM171BBioGRID34079125 details
AFDNFAM83BBioGRID34079125 details
AFDNFLOT2BioGRID34079125 details
AFDNFRMD4BBioGRID34079125 details
AFDNFRMD6BioGRID34079125 details
AFDNFRS2BioGRID34079125 details
AFDNGOLGB1BioGRID34079125 details
AFDNILDR2BioGRID34079125 details
AFDNITGB1BioGRID34079125 details
AFDNJCADBioGRID34079125 details
AFDNKCNB2BioGRID34079125 details
AFDNKIAA0754BioGRID34079125 details
AFDNKIAA1217BioGRID34079125 details
AFDNKIAA1671BioGRID34079125 details
AFDNKIDINS220BioGRID34079125 details
AFDNKIF14BioGRID34079125 details
AFDNKIRREL1BioGRID34079125 details
AFDNLLGL1BioGRID34079125 details
AFDNLSRBioGRID34079125 details
AFDNLZTS1BioGRID34079125 details
AFDNMAP4K4BioGRID34079125 details
AFDNMARK2BioGRID34079125 details
AFDNMARK3BioGRID34079125 details
AFDNMINK1BioGRID34079125 details
AFDNMLLT6BioGRID34079125 details
AFDNMPHOSPH9BioGRID34079125 details
AFDNNINBioGRID34079125 details
AFDNNUMBBioGRID34079125 details
AFDNOCLNBioGRID34079125 details
AFDNPAK4BioGRID34079125 details
AFDNPAK6BioGRID34079125 details
AFDNPARD3BioGRID34079125 details
AFDNPCDH7BioGRID34079125 details
AFDNPEAK1BioGRID34079125 details
AFDNPHACTR4BioGRID34079125 details
AFDNPHLDB2BioGRID34079125 details
AFDNPKP2BioGRID34079125 details
AFDNPKP4BioGRID34079125 details
AFDNPLCH1BioGRID34079125 details
AFDNPLEKHA5BioGRID34079125 details
AFDNPLEKHA7BioGRID34079125 details
AFDNPPFIBP1BioGRID34079125 details
AFDNPPP1R13BBioGRID34079125 details
AFDNPPP1R9ABioGRID34079125 details
AFDNPSMD1BioGRID34079125 details
AFDNPTPN13BioGRID34079125 details
AFDNPTPN14BioGRID34079125 details
AFDNRASAL2BioGRID34079125 details
AFDNRASSF8BioGRID34079125 details
AFDNROCK1BioGRID34079125 details
AFDNROR2BioGRID34079125 details
AFDNSCRIBBioGRID34079125 details
AFDNENTR1BioGRID34079125 details
AFDNSDK1BioGRID34079125 details
AFDNSDK2BioGRID34079125 details
AFDNSHBBioGRID34079125 details
AFDNSHROOM1BioGRID34079125 details
AFDNSHROOM3BioGRID34079125 details
AFDNSIPA1L2BioGRID34079125 details
AFDNSIPA1L3BioGRID34079125 details
AFDNSLC12A2BioGRID34079125 details
AFDNSLC19A1BioGRID34079125 details
AFDNSLC38A1BioGRID34079125 details
AFDNSLC38A2BioGRID34079125 details
AFDNSLC3A2BioGRID34079125 details
AFDNSLC4A7BioGRID34079125 details
AFDNSLC6A15BioGRID34079125 details
AFDNSLC6A8BioGRID34079125 details
AFDNSLC7A5BioGRID34079125 details
AFDNSNAP23BioGRID34079125 details
AFDNSPECC1BioGRID34079125 details
AFDNTJP2BioGRID34079125 details
AFDNTNRC6ABioGRID34079125 details
AFDNTP53BP2BioGRID34079125 details
AFDNTXNL1BioGRID34079125 details
AFDNUSP54BioGRID34079125 details
AFDNUSP6NLBioGRID34079125 details
AFDNUTRNBioGRID34079125 details
AFDNVANGL1BioGRID34079125 details
AFDNVANGL2BioGRID34079125 details
AFDNWDR6BioGRID34079125 details
AFDNXPR1BioGRID34079125 details
AFDNYES1BioGRID34079125 details
AFDNZDHHC5BioGRID34079125 details
AFDNADCY9BioGRID34079125 details
AFDNBASP1BioGRID34079125 details
AFDNCEP152BioGRID34079125 details
AFDNCEP192BioGRID34079125 details
AFDNCPNE8BioGRID34079125 details
AFDNDNMBPBioGRID34079125 details
AFDNDTNABioGRID34079125 details
AFDNEFNB1BioGRID34079125 details
AFDNNIBAN2BioGRID34079125 details
AFDNGAB1BioGRID34079125 details
AFDNGCC2BioGRID34079125 details
AFDNJUPBioGRID34079125 details
AFDNOFD1BioGRID34079125 details
AFDNPLEKHA1BioGRID34079125 details
AFDNSLC1A5BioGRID34079125 details
AFDNTCHPBioGRID34079125 details
AFDNTMF1BioGRID34079125 details
AFDNTNRC6BBioGRID34079125 details
AFDNTPGS1BioGRID34079125 details
AFDNTRIP11BioGRID34079125 details
AFDNYKT6BioGRID34079125 details
AFDNRHOBBioGRID34079125 details
AFDNTRIM25BioGRID29117863 details