Entity Details

Primary name MYD88
Entity type gene
Source Source Link

Details

PrimaryID4615
RefseqGeneNG_016964
SymbolMYD88
NameMYD88 innate immune signal transduction adaptor
Chromosome3
Location3p22.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1997-12-23
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsMYD88_HUMAN

GO terms

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GOName
GO:0002224 toll-like receptor signaling pathway
GO:0002238 response to molecule of fungal origin
GO:0002269 leukocyte activation involved in inflammatory response
GO:0002283 neutrophil activation involved in immune response
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0005121 Toll binding
GO:0005123 death receptor binding
GO:0005149 interleukin-1 receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007254 JNK cascade
GO:0008063 Toll signaling pathway
GO:0009615 response to virus
GO:0009682 induced systemic resistance
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0014069 postsynaptic density
GO:0016064 immunoglobulin mediated immune response
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032481 positive regulation of type I interferon production
GO:0032494 response to peptidoglycan
GO:0032722 positive regulation of chemokine production
GO:0032740 positive regulation of interleukin-17 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0034162 toll-like receptor 9 signaling pathway
GO:0035325 Toll-like receptor binding
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0042832 defense response to protozoan
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043621 protein self-association
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050727 regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060337 type I interferon signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0070944 neutrophil-mediated killing of bacterium
GO:0070976 TIR domain binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0090557 establishment of endothelial intestinal barrier
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1902622 regulation of neutrophil migration
GO:2000338 regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production

Diseases

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Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
MYD88IRAK4BioGRID, DIP, HPRD, IntAct11960013 12538665 12860405 17548806 18221795 20485341 22011580 24316379 24735611 25416956 25502805 25910212 26871637 31515488 32296183 details
MYD88FADDBioGRID, HPRD, IntAct10880445 11828002 21988832 details
MYD88TIRAPBioGRID, DIP, HPRD, IntAct, MINT, UniProt11544529 17258210 17583698 18221795 20048342 21334391 24316379 28483816 details
MYD88MYD88BioGRID, DIP, HPIDb, HPRD, IntAct, MINT11544529 11909531 17258210 17548806 21516116 21988832 22155231 24316379 25416956 25910212 27107012 29892012 31930677 32296183 9575168 details
MYD88SPOPBioGRID, HPRD, IntAct16189514 21988832 26186194 28514442 31776466 details
MYD88TLR2BioGRID, HPRD, IntAct, MINT, UniProt15107846 16293622 16482509 17126326 29990310 details
MYD88TLR4BioGRID, HPRD, IntAct, MINT10952994 11743586 12646618 15107846 15728506 17126326 17258210 18221795 20048342 21829704 21911421 33052227 details
MYD88TLR5BioGRID, HPRD, MINT15107846 16482509 17583698 details
MYD88STAP2BioGRID, HPRD, IntAct16365431 details
MYD88TNFRSF13BBioGRID, InnateDB20676093 details
MYD88MDM2BioGRID, IntAct21988832 details
MYD88PRDX1BioGRID, IntAct21988832 details
MYD88PFKLBioGRID, IntAct21988832 details
MYD88MBIPBioGRID, IntAct21988832 details
MYD88SMAD3BioGRID, IntAct21988832 details
MYD88MALBioGRID, IntAct21988832 details
MYD88TXNBioGRID, IntAct21988832 details
MYD88SIAH2BioGRID, IntAct21988832 details
MYD88SIAH1BioGRID, IntAct21988832 32117091 details
MYD88USP7BioGRID, IntAct21988832 details
MYD88POLR1CBioGRID, IntAct21988832 details
MYD88CD93BioGRID, IntAct21988832 details
MYD88TLR7BioGRID, HPRD, IntAct16482509 21988832 details
MYD88SARM1BioGRID, IntAct17258210 26592460 details
MYD88ZNF35BioGRID, IntAct32296183 details
MYD88RNF4BioGRID, IntAct32296183 details
MYD88NTAQ1BioGRID, IntAct32296183 details
MYD88SPOPLBioGRID, IntAct32296183 details
MYD88TLR9BioGRID15107846 21911421 details
MYD88TLR3BioGRID, HPRD12646618 details
MYD88RAC1BioGRID11416133 details
MYD88IRF7BioGRID, HPRD15361868 16484229 details
MYD88CISHBioGRID16961462 details
MYD88IRF5BioGRID, HPRD15665823 details
MYD88IKBKGBioGRID23986494 details
MYD88RNF152BioGRID31930677 details
MYD88PELI2HPRD12860405 details
MYD88TLR8HPRD16482509 details
MYD88IRAK3BioGRID, HPRD, MINT10383454 details
MYD88IRAK1BioGRID, DIP, HPIDb, HPRD, MINT10383454 10854325 11544529 11960013 11976320 12538665 16024789 16461741 16951688 17276401 17548806 17567694 17920759 21179087 21903422 22011580 31776466 33052227 details
MYD88IRAK2BioGRID, DIP, HPRD, MINT10383454 12659850 20485341 22011580 9374458 details
MYD88IL1RL1BioGRID, HPRD, UniProt15004556 16286016 details
MYD88TRAF6BioGRID, InnateDB16517750 20676093 22011580 23381138 23831471 31243359 31268348 33052227 details
MYD88DOCK8InnateDB22581261 details
MYD88PTK2BInnateDB22581261 details
MYD88CYTH2BioGRID, DIP23143332 details
MYD88TLR10HPRD, IntAct15728506 details
MYD88HDAC6BioGRID, IntAct20837465 29281743 31268348 details
MYD88IL1R1BioGRID, HPRD10854325 12609980 12659850 22904187 24735611 9374458 9575168 details
MYD88LRRFIP1BioGRID19265123 details
MYD88LRRFIP2BioGRID19265123 details
MYD88FLIIBioGRID, HPRD16424162 19265123 details
MYD88SQSTM1BioGRID20837465 details
MYD88CBLBBioGRID20639876 details
MYD88TNIP1BioGRID22011580 details
MYD88TRAF3BioGRID22011580 details
MYD88BTKBioGRID, HPRD12724322 details
MYD88PELI1BioGRID16951688 details
MYD88SMAD6BioGRID21897371 details
MYD88SMURF1BioGRID21897371 details
MYD88BST2BioGRID23221546 details
MYD88IKBKEBioGRID23453969 details
MYD88SASH1BioGRID23776175 details
MYD88SYKBioGRID23962979 details
MYD88IRF4BioGRID, HPRD16236719 24670424 details
MYD88CYLDBioGRID26719415 details
MYD88UBAP1BioGRID28483816 details
MYD88TSG101BioGRID28483816 details
MYD88PIK3AP1BioGRID27909057 details
MYD88ATG5BioGRID23831471 details
MYD88BANK1BioGRID31243359 details
MYD88IL1RAPHPRD11880380 details
MYD88IKBKBIntAct16365431 details
MYD88TRAF2InnateDB20676093 details
MYD88CAMLGInnateDB20676093 details
MYD88AGERIntAct21829704 details
MYD88TRIM28BioGRID29955894 details
MYD88PLEKHA4BioGRID31091453 details
MYD88INSBioGRID32457219 details
MYD88HNRNPLBioGRID28611215 details