Entity Details

Primary name NOTCH2
Entity type gene
Source Source Link

Details

PrimaryID4853
RefseqGeneNG_008163
SymbolNOTCH2
Namenotch receptor 2
Chromosome1
Location1p12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1995-01-30
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsNOTC2_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0001701 in utero embryonic development
GO:0001709 cell fate determination
GO:0001947 heart looping
GO:0002011 morphogenesis of an epithelial sheet
GO:0002315 marginal zone B cell differentiation
GO:0002437 inflammatory response to antigenic stimulus
GO:0003162 atrioventricular node development
GO:0003184 pulmonary valve morphogenesis
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0009887 animal organ morphogenesis
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0010838 positive regulation of keratinocyte proliferation
GO:0016020 membrane
GO:0019827 stem cell population maintenance
GO:0019899 enzyme binding
GO:0030097 hemopoiesis
GO:0030326 embryonic limb morphogenesis
GO:0030513 positive regulation of BMP signaling pathway
GO:0035264 multicellular organism growth
GO:0035622 intrahepatic bile duct development
GO:0038023 signaling receptor activity
GO:0042060 wound healing
GO:0042742 defense response to bacterium
GO:0043011 myeloid dendritic cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0045672 positive regulation of osteoclast differentiation
GO:0045967 negative regulation of growth rate
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046849 bone remodeling
GO:0051059 NF-kappaB binding
GO:0060413 atrial septum morphogenesis
GO:0060674 placenta blood vessel development
GO:0061073 ciliary body morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070986 left/right axis specification
GO:0072014 proximal tubule development
GO:0072015 glomerular visceral epithelial cell development
GO:0072104 glomerular capillary formation
GO:0072574 hepatocyte proliferation
GO:1990705 cholangiocyte proliferation
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2001204 regulation of osteoclast development

Diseases

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Interactions

149 interactions

InteractorPartnerSourcesPublicationsLink
NOTCH2SMAD1BioGRID, HPRD, MINT15231748 details
NOTCH2CRKLBioGRID, IntAct18654987 details
NOTCH2ANKRD28BioGRID, IntAct23414517 24255178 details
NOTCH2CST6BioGRID, MINT25640309 details
NOTCH2EPSTI1BioGRID, MINT25640309 details
NOTCH2LRATD2BioGRID, MINT25640309 details
NOTCH2IL13RA2BioGRID, MINT25640309 details
NOTCH2IL24BioGRID, MINT25640309 details
NOTCH2ITIH5BioGRID, MINT25640309 details
NOTCH2KLK5BioGRID, MINT25640309 details
NOTCH2MTA3BioGRID, MINT25640309 details
NOTCH2PSMC3IPBioGRID, MINT25640309 details
NOTCH2ST14BioGRID, MINT25640309 details
NOTCH2RBPJBioGRID, HPRD, IntAct, MINT25609649 26186194 26496610 28514442 9032325 details
NOTCH2CCR2BioGRID, MINT28298427 details
NOTCH2GSK3BBioGRID, HPRD12794074 details
NOTCH2JAG1BioGRID, HPRD10551863 10958687 11346656 details
NOTCH2DLL1BioGRID, HPRD10958687 11346656 9244302 details
NOTCH2MAML1BioGRID, HPRD11101851 details
NOTCH2JAG2BioGRID, HPRD10958687 details
NOTCH2MYOCBioGRID, HPRD16289162 details
NOTCH2EGFL7BioGRID19503073 details
NOTCH2DTX3BioGRID31854042 details
NOTCH2CNTN1BioGRID, HPRD14567914 details
NOTCH2CASRBioGRID17573339 details
NOTCH2ST7BioGRID29395067 details
NOTCH2SMAP2BioGRID29395067 details
NOTCH2DTX3LBioGRID31854042 details
NOTCH2LFNGHPRD11346656 details
NOTCH2MFNGHPRD11346656 details
NOTCH2DTX1HPRD9244302 details
NOTCH2PSEN1HPRD11518718 details
NOTCH2PSEN2HPRD11518718 details
NOTCH2MAML2HPRD12370315 details
NOTCH2MAML3HPRD12370315 details
NOTCH2HIF1ANBioGRID, IntAct26972000 details
NOTCH2EGLN3BioGRID, IntAct26972000 details
NOTCH2TMEM17BioGRID, IntAct26638075 details
NOTCH2GOLM1IntAct27569582 details
NOTCH2NOTCH1BioGRID, MINT23022380 details
NOTCH2HSCBBioGRID, IntAct28380382 details
NOTCH2RABGGTBBioGRID, IntAct26186194 28514442 details
NOTCH2ZFP41BioGRID, IntAct26186194 28514442 details
NOTCH2VASNBioGRID, IntAct28514442 details
NOTCH2ANKRD44BioGRID, IntAct26186194 28514442 details
NOTCH2LRRIQ1BioGRID, IntAct28514442 details
NOTCH2AGRPBioGRID, IntAct28514442 details
NOTCH2BET1BioGRID, IntAct29568061 details
NOTCH2EZRBioGRID, IntAct29568061 34079125 details
NOTCH2LAMP1BioGRID, IntAct29568061 34079125 details
NOTCH2TGOLN2BioGRID, IntAct29568061 details
NOTCH2SPENBioGRID22939629 details
NOTCH2NDUFV2BioGRID22939629 details
NOTCH2NDUFV1BioGRID22939629 details
NOTCH2SEC24CBioGRID22939629 details
NOTCH2PCMT1BioGRID22939629 details
NOTCH2PSMB1BioGRID22939629 details
NOTCH2TJP1BioGRID22939629 details
NOTCH2SIN3ABioGRID22939629 details
NOTCH2PLAURBioGRID22939629 details
NOTCH2LATS2BioGRID24255178 details
NOTCH2ASB14BioGRID24337577 details
NOTCH2EEF2BioGRID26344197 details
NOTCH2AFDNBioGRID26344197 34079125 details
NOTCH2ATP2A2BioGRID26344197 details
NOTCH2CDC42BioGRID26344197 details
NOTCH2MSNBioGRID26344197 details
NOTCH2RDXBioGRID26344197 details
NOTCH2PDIA6BioGRID26344197 details
NOTCH2FBXL17BioGRID27234298 details
NOTCH2CDH1BioGRID25468996 details
NOTCH2ZNF598BioGRID28685749 details
NOTCH2RNF4BioGRID29180619 details
NOTCH2ESR2BioGRID29509190 details
NOTCH2NRASBioGRID30194290 30639242 details
NOTCH2KRASBioGRID30194290 34079125 details
NOTCH2NR2C2BioGRID30463901 details
NOTCH2RPS6KA2BioGRID31678930 details
NOTCH2DYRK1ABioGRID31024071 details
NOTCH2RHBDD1BioGRID31177093 details
NOTCH2RHBDF2BioGRID31177093 details
NOTCH2GARRE1BioGRID29395067 details
NOTCH2RETBioGRID32062451 details
NOTCH2PTPRABioGRID32062451 details
NOTCH2PRC1BioGRID31586073 details
NOTCH2TRIM66BioGRID31753913 details
NOTCH2SEC61BBioGRID32788342 34079125 details
NOTCH2FBXW7BioGRID31285543 details
NOTCH2DNAJC1BioGRID33957083 details
NOTCH2DNAJC25BioGRID33957083 details
NOTCH2DNAJC5BioGRID33957083 details
NOTCH2DNAJA2BioGRID33957083 details
NOTCH2MARCHF2BioGRID32614325 details
NOTCH2MARCHF3BioGRID32614325 details
NOTCH2MARCHF8BioGRID32614325 details
NOTCH2TRIM37BioGRID32908313 details
NOTCH2ARF6BioGRID34079125 details
NOTCH2ATP2A1BioGRID34079125 details
NOTCH2B3GAT1BioGRID34079125 details
NOTCH2C11orf52BioGRID34079125 details
NOTCH2CAV1BioGRID34079125 details
NOTCH2CKAP4BioGRID34079125 details
NOTCH2CXADRBioGRID34079125 details
NOTCH2DERL1BioGRID34079125 details
NOTCH2DIRAS3BioGRID34079125 details
NOTCH2EBAG9BioGRID34079125 details
NOTCH2ELOVL5BioGRID34079125 details
NOTCH2EMDBioGRID34079125 details
NOTCH2EPB41L4ABioGRID34079125 details
NOTCH2ERGIC1BioGRID34079125 details
NOTCH2FLOT1BioGRID34079125 details
NOTCH2GJA1BioGRID34079125 details
NOTCH2GJD3BioGRID34079125 details
NOTCH2HSD17B11BioGRID34079125 details
NOTCH2HSD3B7BioGRID34079125 details
NOTCH2LAMP2BioGRID34079125 details
NOTCH2LAMP3BioGRID34079125 details
NOTCH2LAMTOR1BioGRID34079125 details
NOTCH2LATS1BioGRID34079125 details
NOTCH2LCKBioGRID34079125 details
NOTCH2LMAN1BioGRID34079125 details
NOTCH2LRRC59BioGRID34079125 details
NOTCH2LYNBioGRID34079125 details
NOTCH2MARCKSBioGRID34079125 details
NOTCH2METTL7ABioGRID34079125 details
NOTCH2OCLNBioGRID34079125 details
NOTCH2PANX1BioGRID34079125 details
NOTCH2PARD3BioGRID34079125 details
NOTCH2RAB11ABioGRID34079125 details
NOTCH2RAB2ABioGRID34079125 details
NOTCH2RAB35BioGRID34079125 details
NOTCH2RAB3BBioGRID34079125 details
NOTCH2RAB4ABioGRID34079125 details
NOTCH2RAB5ABioGRID34079125 details
NOTCH2RAB5CBioGRID34079125 details
NOTCH2RAB9ABioGRID34079125 details
NOTCH2RHOBBioGRID34079125 details
NOTCH2RPN1BioGRID34079125 details
NOTCH2SEC62BioGRID34079125 details
NOTCH2STX4BioGRID34079125 details
NOTCH2STX6BioGRID34079125 details
NOTCH2STX7BioGRID34079125 details
NOTCH2SYNE3BioGRID34079125 details
NOTCH2TMPOBioGRID34079125 details
NOTCH2ZFPL1BioGRID34079125 details
NOTCH2ZYXBioGRID34079125 details
NOTCH2HNRNPLBioGRID28611215 details
NOTCH2VIRMABioGRID29507755 details
NOTCH2MKRN2BioGRID32460013 details