Entity Details

Primary name FURIN
Entity type gene
Source Source Link

Details

PrimaryID5045
RefseqGene
SymbolFURIN
Namefurin, paired basic amino acid cleaving enzyme
Chromosome15
Location15q26.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1992-06-26
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsFURIN_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001825 blastocyst formation
GO:0002020 protease binding
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005796 Golgi lumen
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0006465 signal peptide processing
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008233 peptidase activity
GO:0009966 regulation of signal transduction
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0019058 viral life cycle
GO:0019082 viral protein processing
GO:0022617 extracellular matrix disassembly
GO:0030140 trans-Golgi network transport vesicle
GO:0030173 integral component of Golgi membrane
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031638 zymogen activation
GO:0032374 regulation of cholesterol transport
GO:0032455 nerve growth factor processing
GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0032902 nerve growth factor production
GO:0032911 negative regulation of transforming growth factor beta1 production
GO:0032940 secretion by cell
GO:0042176 regulation of protein catabolic process
GO:0042277 peptide binding
GO:0043043 peptide biosynthetic process
GO:0045121 membrane raft
GO:0046872 metal ion binding
GO:0048406 nerve growth factor binding
GO:0051004 regulation of lipoprotein lipase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0052548 regulation of endopeptidase activity
GO:0070062 extracellular exosome
GO:0070268 cornification
GO:0090472 dibasic protein processing
GO:0097341 zymogen inhibition
GO:1901394 positive regulation of transforming growth factor beta1 activation
GO:1990000 amyloid fibril formation

Diseases

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Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
FURINMMP14BioGRID, IntAct, MINT20608975 21152186 8804434 details
FURINMST1RMolecular Connections21114864 details
FURINABCC6BioGRID, IntAct21988832 details
FURINMSTNMINT23829672 25543063 details
FURINAPPIntAct32814053 details
FURINSERPINB8BioGRID, HPRD9442015 details
FURINAP2M1BioGRID, HPRD10593987 details
FURINPACS1BioGRID, HPRD11331585 9695949 details
FURINFLNCHPRD9412467 details
FURINDDX56IntAct17353931 details
FURINTGOLN2MINT16977309 details
FURINGORASP2MINT20608975 details
FURINMMP28IntAct21152186 details
FURINLRP1HPRD2112085 8546712 details
FURINSORCS1HPRD12482870 details
FURINADAMTS4HPRD14744861 details
FURINPMCHHPRD10037747 details
FURINFURINHPRD11237874 1629222 details
FURINDSG3HPRD12586364 details
FURINZP3HPRD11804956 details
FURINNOTCH1HPRD9653148 details
FURINFLNAHPRD9412467 details
FURINEDAHPRD11416205 details
FURINSORL1HPRD11294867 details
FURINTNFSF13HPRD11571266 details
FURINCNMDHPRD11323410 details
FURINADAMTS1HPRD10373500 details
FURINBACE1HPRD10887202 details
FURINNAGPAHPRD12058031 details
FURINCOL23A1HPRD12644459 details
FURINITM2CHPRD15606899 details
FURINZP4HPRD11804956 details
FURINPDGFAHPRD12670890 details
FURINVWFHPRD1571548 details
FURINHUWE1BioGRID, IntAct26496610 details
FURINSGTBBioGRID, IntAct26496610 details
FURINBAG6BioGRID, IntAct26496610 details
FURINFCGRTBioGRID, IntAct28514442 details
FURINSERPINA5BioGRID, IntAct28514442 details
FURINHTR3ABioGRID, IntAct28514442 details
FURINPXYLP1BioGRID, IntAct28514442 details
FURINHNRNPMBioGRID, IntAct30021884 details
FURINKRT6CBioGRID, IntAct30021884 details
FURINSERPINH1BioGRID, IntAct30021884 details
FURINELAVL1BioGRID19322201 details