Entity Details

Primary name IL17_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16552
EntryNameIL17_HUMAN
FullNameInterleukin-17A
TaxID9606
Evidenceevidence at protein level
Length155
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesIL17A

GO terms

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GOName
GO:0002225 positive regulation of antimicrobial peptide production
GO:0002250 adaptive immune response
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:0008219 cell death
GO:0009897 external side of plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032739 positive regulation of interleukin-16 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042803 protein homodimerization activity
GO:0045087 innate immune response
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0060729 intestinal epithelial structure maintenance
GO:0071347 cellular response to interleukin-1
GO:0072537 fibroblast activation
GO:0097400 interleukin-17-mediated signaling pathway
GO:0097530 granulocyte migration
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1903348 positive regulation of bicellular tight junction assembly
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR010345 Interleukin-17 familyFamilyFamily
IPR020440 Interleukin-17, chordataFamilyFamily
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09029 SecukinumabDrugbankbiotech
DB11569 IxekizumabDrugbankbiotech

Interactions

6 interactions