Entity Details

Primary name MAPK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16644
EntryNameMAPK3_HUMAN
FullNameMAP kinase-activated protein kinase 3
TaxID9606
Evidenceevidence at protein level
Length382
SequenceStatuscomplete
DateCreated2005-12-06
DateModified2021-06-02

Ontological Relatives

GenesMAPKAPK3

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0002224 toll-like receptor signaling pathway
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0032496 response to lipopolysaccharide
GO:0034097 response to cytokine
GO:0035556 intracellular signal transduction
GO:0044351 macropinocytosis
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0051019 mitogen-activated protein kinase binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR027442 MAP kinase activated protein kinase, C-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07728 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONEDrugbanksmall molecule
DB08358 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONEDrugbanksmall molecule

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
MAPK3_HUMANMK11_HUMANBioGRID, IntAct21988832 23602568 26186194 28514442 details
MAPK3_HUMANHSPB1_HUMANBioGRID, HPRD, IntAct, Molecular Connections21575178 25241761 8774846 details
MAPK3_HUMANCSN6_HUMANBioGRID, MINT21900206 details
MAPK3_HUMANEZH2_HUMANBioGRID, MINT21900206 details
MAPK3_HUMANIGHM_HUMANMINT21900206 details
MAPK3_HUMANRAB2A_HUMANBioGRID, MINT21900206 details
MAPK3_HUMANSPSY_HUMANBioGRID, MINT21900206 details
MAPK3_HUMANSUMO3_HUMANBioGRID, MINT21900206 details
MAPK3_HUMANMK14_HUMANBioGRID, HPRD, IntAct11157753 15331440 23455922 23602568 25241761 25852190 26186194 26496610 28514442 31515488 31980649 details
MAPK3_HUMANAURKA_HUMANMINT24412244 details
MAPK3_HUMANBRAF_HUMANMINT24412244 details
MAPK3_HUMANBUB1_HUMANMINT24412244 details
MAPK3_HUMANCADH1_HUMANMINT24412244 details
MAPK3_HUMANARF_HUMANMINT24412244 details
MAPK3_HUMANDCC_HUMANMINT24412244 details
MAPK3_HUMANRHG07_HUMANMINT24412244 details
MAPK3_HUMANEGFR_HUMANMINT24412244 details
MAPK3_HUMANFBXW7_HUMANMINT24412244 details
MAPK3_HUMANRASN_HUMANMINT24412244 details
MAPK3_HUMANPGFRL_HUMANMINT24412244 details
MAPK3_HUMANRB_HUMANMINT24412244 details
MAPK3_HUMANSRC_HUMANMINT24412244 details
MAPK3_HUMANSTK11_HUMANMINT24412244 details
MAPK3_HUMANTFE2_HUMANBioGRID, HPRD10781029 details
MAPK3_HUMANNEDD4_HUMANBioGRID19953087 details
MAPK3_HUMANNED4L_HUMANBioGRID19953087 details
MAPK3_HUMANPHC2_HUMANBioGRID15563468 details
MAPK3_HUMANA4_HUMANBioGRID21832049 details
MAPK3_HUMANSRPK2_HUMANBioGRID26167880 details
MAPK3_HUMANATF1_HUMANBioGRID11335727 details
MAPK3_HUMANP52K_HUMANBioGRID20484669 details
MAPK3_HUMANCPZIP_HUMANBioGRID15850461 details
MAPK3_HUMANBECN1_HUMANBioGRID25693418 details
MAPK3_HUMANMK13_HUMANBioGRID, HPRD, IntAct25241761 9207191 details
MAPK3_HUMANBMI1_HUMANBioGRID15563468 details
MAPK3_HUMANRING2_HUMANBioGRID15563468 details
MAPK3_HUMANEF2K_HUMANHPRD12171600 details
MAPK3_HUMANEF2_HUMANHPRD12171600 details