Entity Details

Primary name PKD2
Entity type gene
Source Source Link

Details

PrimaryID5311
RefseqGeneNG_008604
SymbolPKD2
Namepolycystin 2, transient receptor potential cation channel
Chromosome4
Location4q22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-02-07
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsPKD2_HUMAN

GO terms

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GOName
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0001947 heart looping
GO:0002133 polycystin complex
GO:0003127 detection of nodal flow
GO:0005102 signaling receptor binding
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005261 cation channel activity
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005929 cilium
GO:0006816 calcium ion transport
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007368 determination of left/right symmetry
GO:0007507 heart development
GO:0008092 cytoskeletal protein binding
GO:0008285 negative regulation of cell population proliferation
GO:0009925 basal plasma membrane
GO:0010628 positive regulation of gene expression
GO:0015271 outward rectifier potassium channel activity
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016323 basolateral plasma membrane
GO:0021510 spinal cord development
GO:0021915 neural tube development
GO:0022843 voltage-gated cation channel activity
GO:0030027 lamellipodium
GO:0030659 cytoplasmic vesicle membrane
GO:0031514 motile cilium
GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0034614 cellular response to reactive oxygen species
GO:0034703 cation channel complex
GO:0035502 metanephric part of ureteric bud development
GO:0035725 sodium ion transmembrane transport
GO:0035904 aorta development
GO:0036064 ciliary basal body
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042805 actinin binding
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043398 HLH domain binding
GO:0044325 transmembrane transporter binding
GO:0044782 cilium organization
GO:0045180 basal cortex
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048763 calcium-induced calcium release activity
GO:0050982 detection of mechanical stimulus
GO:0051117 ATPase binding
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051219 phosphoprotein binding
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0051290 protein heterotetramerization
GO:0051298 centrosome duplication
GO:0051371 muscle alpha-actinin binding
GO:0060170 ciliary membrane
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060674 placenta blood vessel development
GO:0061333 renal tubule morphogenesis
GO:0061441 renal artery morphogenesis
GO:0070062 extracellular exosome
GO:0070588 calcium ion transmembrane transport
GO:0071277 cellular response to calcium ion
GO:0071320 cellular response to cAMP
GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071464 cellular response to hydrostatic pressure
GO:0071470 cellular response to osmotic stress
GO:0071498 cellular response to fluid shear stress
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:0071805 potassium ion transmembrane transport
GO:0071910 determination of liver left/right asymmetry
GO:0072075 metanephric mesenchyme development
GO:0072164 mesonephric tubule development
GO:0072177 mesonephric duct development
GO:0072208 metanephric smooth muscle tissue development
GO:0072214 metanephric cortex development
GO:0072218 metanephric ascending thin limb development
GO:0072219 metanephric cortical collecting duct development
GO:0072235 metanephric distal tubule development
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072686 mitotic spindle
GO:0090279 regulation of calcium ion import
GO:0097730 non-motile cilium
GO:0098662 inorganic cation transmembrane transport
GO:0198738 cell-cell signaling by wnt
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
PKD2PKD2BioGRID, DIP, HPRD, MINT19556541 20168298 21622852 27991905 28092368 9192675 details
PKD2PKD1bhf-ucl, BioGRID, DIP, HPRD, MINT10097141 11901144 19556541 20168298 21126580 21642537 30093605 9192675 details
PKD2HAX1bhf-ucl, HPRD10760273 details
PKD2ID2bhf-ucl16311606 details
PKD2TRPC1bhf-ucl, BioGRID, HPRD, IntAct10097141 25114176 details
PKD2PLSCR1BioGRID, IntAct25416956 details
PKD2MAGEA8BioGRID, IntAct25416956 29892012 details
PKD2KRTAP10-8BioGRID, IntAct25416956 details
PKD2KRT40BioGRID, IntAct25416956 details
PKD2CYSRT1BioGRID, IntAct32296183 details
PKD2HSF2BPBioGRID, IntAct32296183 details
PKD2MDFIBioGRID, IntAct32296183 details
PKD2KRTAP6-2BioGRID, IntAct32296183 details
PKD2TNNI3BioGRID, HPRD12525172 details
PKD2KRTAP10-3BioGRID25416956 details
PKD2LMNABioGRID24623722 details
PKD2PTPRGBioGRID21126580 details
PKD2CD2APHPRD10913159 details
PKD2ACTN2HPRD15843396 details
PKD2TPM1HPRD12527301 details
PKD2DIAPH1bhf-ucl, HPRD, MINT15123714 18388856 details
PKD2BCAP31MINT19153608 details
PKD2GCC2BioGRID, IntAct27173435 unassigned1312 details
PKD2CANXBioGRID11901144 details
PKD2GOLGA2BioGRID11901144 details
PKD2ATP1A1BioGRID11901144 details
PKD2AKT1BioGRID24462114 details
PKD2PACS2HPRD15692563 details
PKD2PACS1HPRD15692563 details
PKD2PICK1BioGRID, IntAct26186194 28514442 details
PKD2CRYL1BioGRID, IntAct28514442 details
PKD2CEP170BioGRID, IntAct26186194 28514442 details
PKD2EXOC3BioGRID, IntAct28514442 details
PKD2COG6BioGRID, IntAct28514442 details
PKD2CNGA3BioGRID, IntAct28514442 details
PKD2PTGIRBioGRID, IntAct28514442 details
PKD2CHRNDBioGRID, IntAct28514442 details
PKD2GLRA2BioGRID, IntAct26186194 28514442 details
PKD2TMPRSS12BioGRID, IntAct28514442 details
PKD2TPTE2BioGRID, IntAct28514442 details
PKD2BCAS4BioGRID, IntAct26186194 28514442 details
PKD2CD300EBioGRID, IntAct28514442 details
PKD2PKD2L2BioGRID, IntAct28514442 details
PKD2ALG5BioGRID, IntAct26186194 28514442 details
PKD2FAM3DBioGRID, IntAct26186194 28514442 details
PKD2SRPRABioGRID26496610 details
PKD2TMEM248BioGRID26496610 details
PKD2RPN2BioGRID34079125 details
PKD2SEC62BioGRID34079125 details
PKD2HNRNPLBioGRID28611215 details