Entity Details

Primary name APPL2
Entity type gene
Source Source Link

Details

PrimaryID55198
RefseqGeneNG_030419
SymbolAPPL2
Nameadaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Chromosome12
Location12q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-07-03
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsDP13B_HUMAN

GO terms

Show/Hide Table
GOName
GO:0001726 ruffle
GO:0001786 phosphatidylserine binding
GO:0002024 diet induced thermogenesis
GO:0005634 nucleus
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0006606 protein import into nucleus
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0009631 cold acclimation
GO:0010008 endosome membrane
GO:0010762 regulation of fibroblast migration
GO:0016020 membrane
GO:0023052 signaling
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0031982 vesicle
GO:0032009 early phagosome
GO:0032587 ruffle membrane
GO:0033211 adiponectin-activated signaling pathway
GO:0034143 regulation of toll-like receptor 4 signaling pathway
GO:0035091 phosphatidylinositol binding
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0036186 early phagosome membrane
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044354 macropinosome
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0046322 negative regulation of fatty acid oxidation
GO:0046325 negative regulation of glucose import
GO:0050768 negative regulation of neurogenesis
GO:0051289 protein homotetramerization
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0070062 extracellular exosome
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:1905303 positive regulation of macropinocytosis
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:2000178 negative regulation of neural precursor cell proliferation

Diseases

Show/Hide Table

Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
APPL2APPL1BioGRID, HPRD, IntAct, UniProt15016378 16189514 17030088 18034774 23414517 24879834 25416956 28514442 31515488 32296183 details
APPL2RAB22ABioGRID, HPRD, IntAct16189514 25416956 31515488 32296183 details
APPL2RBBP7BioGRID, HPRD, IntAct15016378 details
APPL2MTA2BioGRID, HPRD, IntAct15016378 details
APPL2SUV39H2BioGRID, IntAct, MINT23455924 25416956 31515488 32296183 details
APPL2MLST8BioGRID, IntAct25814554 details
APPL2KMT2CBioGRID, IntAct25814554 details
APPL2MAPRE3BioGRID, IntAct25814554 details
APPL2LIX1BioGRID, IntAct25814554 details
APPL2LGALS9BIntAct25814554 details
APPL2RAI2BioGRID, IntAct25814554 details
APPL2LDHAL6BBioGRID, IntAct25814554 details
APPL2PINK1BioGRID, IntAct25814554 details
APPL2CRBNBioGRID, IntAct25814554 details
APPL2RBP7BioGRID, IntAct25814554 details
APPL2TSC1BioGRID, IntAct25814554 details
APPL2CRLF3BioGRID, IntAct25814554 details
APPL2DOK3BioGRID, IntAct25814554 details
APPL2ATF3BioGRID, IntAct25814554 details
APPL2CNMDBioGRID, IntAct25814554 details
APPL2RAB5CBioGRID, IntAct25416956 31515488 32296183 34079125 details
APPL2CRADDBioGRID, IntAct25416956 31515488 details
APPL2TINF2bhf-ucl, BioGRID21044950 details
APPL2POT1bhf-ucl, BioGRID21044950 details
APPL2KIFC3BioGRID, IntAct32296183 details
APPL2PRR35BioGRID, IntAct32296183 details
APPL2EPM2AIP1BioGRID, IntAct32296183 details
APPL2RAB5ABioGRID, HPRD, IntAct, UniProt15016378 18034774 29568061 34079125 details
APPL2APPL2UniProt18034774 details
APPL2RUVBL2BioGRID19433865 details
APPL2LGALS9CBioGRID25814554 details
APPL2TBC1D1UniProt24879834 details
APPL2FMR1IntAct31413325 details
APPL2FSHRBioGRID17030088 details
APPL2LAMP1BioGRID, IntAct29568061 details
APPL2TGOLN2BioGRID, IntAct29568061 details
APPL2YWHAEBioGRID, IntAct30021884 details
APPL2SOS1UniProt24879834 details
APPL2ARAP2UniProt24879834 details
APPL2ESR1BioGRID, IntAct31527615 details
APPL2ABI2BioGRID22863883 details
APPL2RIPOR1BioGRID22863883 details
APPL2TPM1BioGRID22863883 details
APPL2NTRK1BioGRID25921289 details
APPL2MYO6BioGRID29467281 details
APPL2GIPC1BioGRID29467281 details
APPL2ANKFY1BioGRID34079125 details
APPL2LAMP2BioGRID34079125 details
APPL2LAMP3BioGRID34079125 details
APPL2LAMTOR1BioGRID34079125 details
APPL2RAB11ABioGRID34079125 details
APPL2STX7BioGRID34079125 details
APPL2HSPA1AUniProt24879834 details
APPL2HSPA1BUniProt24879834 details
APPL2DDX58BioGRID32513696 details