Entity Details

Primary name PTN
Entity type gene
Source Source Link

Details

PrimaryID5764
RefseqGene
SymbolPTN
Namepleiotrophin
Chromosome7
Location7q33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPTN_HUMAN

GO terms

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GOName
GO:0001889 liver development
GO:0002232 leukocyte chemotaxis involved in inflammatory response
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0004864 protein phosphatase inhibitor activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007399 nervous system development
GO:0007406 negative regulation of neuroblast proliferation
GO:0007507 heart development
GO:0007612 learning
GO:0007613 memory
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009986 cell surface
GO:0010594 regulation of endothelial cell migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010976 positive regulation of neuron projection development
GO:0010996 response to auditory stimulus
GO:0014823 response to activity
GO:0016525 negative regulation of angiogenesis
GO:0019901 protein kinase binding
GO:0021510 spinal cord development
GO:0021549 cerebellum development
GO:0021794 thalamus development
GO:0030282 bone mineralization
GO:0030324 lung development
GO:0030336 negative regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0031104 dendrite regeneration
GO:0031594 neuromuscular junction
GO:0031641 regulation of myelination
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0032991 protein-containing complex
GO:0034644 cellular response to UV
GO:0035373 chondroitin sulfate proteoglycan binding
GO:0035374 chondroitin sulfate binding
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0038085 vascular endothelial growth factor binding
GO:0042246 tissue regeneration
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043113 receptor clustering
GO:0043932 ossification involved in bone remodeling
GO:0044849 estrous cycle
GO:0045446 endothelial cell differentiation
GO:0045545 syndecan binding
GO:0045778 positive regulation of ossification
GO:0045837 negative regulation of membrane potential
GO:0046697 decidualization
GO:0048167 regulation of synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0048477 oogenesis
GO:0048680 positive regulation of axon regeneration
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051781 positive regulation of cell division
GO:0060221 retinal rod cell differentiation
GO:0060253 negative regulation of glial cell proliferation
GO:0060291 long-term synaptic potentiation
GO:0071305 cellular response to vitamin D
GO:0071456 cellular response to hypoxia
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0140059 dendrite arborization
GO:1900006 positive regulation of dendrite development
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1903706 regulation of hemopoiesis
GO:1904373 response to kainic acid
GO:1904389 rod bipolar cell differentiation
GO:1904391 response to ciliary neurotrophic factor
GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering
GO:1904397 negative regulation of neuromuscular junction development
GO:1904399 heparan sulfate binding
GO:1990089 response to nerve growth factor
GO:2000036 regulation of stem cell population maintenance
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000738 positive regulation of stem cell differentiation

Diseases

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Interactions

115 interactions

InteractorPartnerSourcesPublicationsLink
PTNBARD1BioGRID, HPRD, IntAct15383276 details
PTNCHD3BioGRID, HPRD, IntAct15383276 16169070 details
PTNKPNB1BioGRID, HPRD, IntAct15383276 details
PTNGADD45GBioGRID, HPRD, IntAct15383276 details
PTNFEZ1BioGRID, HPRD, IntAct15383276 details
PTNPTNBioGRID, HPRD, IntAct10600521 15383276 details
PTNPIAS4BioGRID, HPRD, IntAct15383276 details
PTNARMCX5-GPRASP2IntAct15383276 details
PTNGPRASP2BioGRID, IntAct15383276 details
PTNBCCIPBioGRID, HPRD, IntAct16169070 details
PTNUBQLN4BioGRID, HPRD, IntAct16169070 16713569 details
PTNPSMD2BioGRID, HPRD, IntAct16169070 details
PTNSGTABioGRID, HPRD, IntAct16169070 21988832 details
PTNARIH2BioGRID, HPRD, IntAct16169070 details
PTNGIPC2BioGRID, HPRD, IntAct16169070 details
PTNRACK1BioGRID, HPRD, IntAct16169070 details
PTNPPP2CABioGRID, HPRD, IntAct16169070 details
PTNPSMD11BioGRID, HPRD, IntAct16169070 details
PTNPTPRSBioGRID, HPRD, IntAct16169070 details
PTNRPLP1BioGRID, HPRD, IntAct16169070 details
PTNSGSM2BioGRID, HPRD, IntAct16169070 details
PTNTOMM20BioGRID, HPRD, IntAct16169070 details
PTNTXNDC9BioGRID, HPRD, IntAct16169070 details
PTNARL15BioGRID, HPRD, IntAct16169070 details
PTNATP5F1CBioGRID, HPRD, IntAct16169070 details
PTNCAPZBBioGRID, HPRD, IntAct16169070 details
PTNWASHC3BioGRID, HPRD, IntAct16169070 details
PTNCRELD1BioGRID, HPRD, IntAct16169070 details
PTNDNAJB11BioGRID, HPRD, IntAct, MINT16169070 21900206 details
PTNEIF3FBioGRID, HPRD, IntAct16169070 details
PTNSLC25A36BioGRID, HPRD, IntAct16169070 details
PTNGPD1BioGRID, HPRD, IntAct16169070 details
PTNGSTP1BioGRID, HPRD, IntAct16169070 details
PTNLAMA4BioGRID, HPRD, IntAct16169070 details
PTNLUC7L2BioGRID, HPRD, IntAct16169070 details
PTNMAD2L1BPBioGRID, HPRD, IntAct16169070 details
PTNP4HBBioGRID, HPRD, IntAct16169070 details
PTNUTP3BioGRID, HPRD, IntAct16169070 details
PTNSAT1BioGRID, HPRD, IntAct16169070 details
PTNSSR1BioGRID, HPRD, IntAct16169070 details
PTNTP53BP2BioGRID, HPRD, IntAct16169070 details
PTNATRXBioGRID, HPRD, IntAct16169070 details
PTNBTBD2BioGRID, HPRD, IntAct16169070 details
PTNCAAP1BioGRID, HPRD, IntAct16169070 details
PTNCACNB4BioGRID, HPRD, IntAct16169070 details
PTNCDH10BioGRID, HPRD, IntAct16169070 details
PTNCDK5RAP2BioGRID, HPRD, IntAct16169070 details
PTNCOX6CBioGRID, HPRD, IntAct16169070 details
PTNDUSP12BioGRID, HPRD, IntAct16169070 details
PTNEVA1ABioGRID, HPRD, IntAct16169070 details
PTNFTLBioGRID, HPRD, IntAct16169070 details
PTNBLOC1S1BioGRID, HPRD, IntAct16169070 details
PTNGLYATBioGRID, HPRD, IntAct16169070 details
PTNGTF2F1BioGRID, HPRD, IntAct16169070 details
PTNITSN2BioGRID, HPRD, IntAct16169070 details
PTNMLLT3BioGRID, HPRD, IntAct16169070 details
PTNMYCBPBioGRID, HPRD, IntAct16169070 details
PTNNAP1L5BioGRID, HPRD, IntAct16169070 details
PTNCRCT1BioGRID, HPRD, IntAct16169070 details
PTNPMF1BioGRID, HPRD, IntAct16169070 details
PTNPSMB10BioGRID, HPRD, IntAct16169070 details
PTNRIT1BioGRID, HPRD, IntAct16169070 details
PTNSNCAIPBioGRID, HPRD, IntAct16169070 details
PTNSTC2BioGRID, HPRD, IntAct16169070 details
PTNTAC3BioGRID, IntAct16169070 details
PTNTBRG4BioGRID, HPRD, IntAct16169070 details
PTNAPOBEC3GBioGRID, HPRD, IntAct16169070 details
PTNCGABioGRID, HPRD, IntAct16169070 details
PTNGSDMEBioGRID, HPRD, IntAct16169070 details
PTNHSPBAP1BioGRID, HPRD, IntAct16169070 details
PTNTAF1DBioGRID, HPRD, IntAct, MINT16169070 21900206 details
PTNMKKSBioGRID, HPRD, IntAct16169070 details
PTNPLXNB2BioGRID, HPRD, IntAct16169070 details
PTNSUPT7LBioGRID, HPRD, IntAct16169070 details
PTNWFDC2BioGRID, HPRD, IntAct16169070 details
PTNCSTAHPRD, IntAct16169070 details
PTNSPIN1HPRD, IntAct16169070 details
PTNCYP2E1BioGRID, IntAct21988832 details
PTNBAG6BioGRID, IntAct21988832 details
PTNTSC22D1BioGRID, IntAct21988832 details
PTNUBQLN1BioGRID, IntAct21988832 details
PTNBCL2L1BioGRID, MINT21900206 details
PTNC11orf58BioGRID, MINT21900206 details
PTNC7orf25BioGRID, MINT21900206 details
PTNGADD45ABioGRID, MINT21900206 details
PTNGSK3BBioGRID, MINT21900206 details
PTNMRPL44BioGRID, MINT21900206 details
PTNNUDT21BioGRID, MINT21900206 details
PTNPFDN1BioGRID, MINT21900206 details
PTNASPHBioGRID, IntAct32296183 details
PTNITGAMUniProt28939773 details
PTNSERPINH1IntAct32814053 details
PTNPRKACAIntAct32814053 details
PTNKLK6IntAct32814053 details
PTNTGFBR2IntAct32814053 details
PTNBMI1BioGRID, HPRD16169070 details
PTNRBM23BioGRID, HPRD16169070 details
PTNHGH1BioGRID, HPRD16169070 details
PTNALKBioGRID, HPRD11278720 details
PTNNEK6BioGRID20873783 details
PTNPMF1-BGLAPIntAct16169070 details
PTNPTPRZ1BioGRID, HPRD10706604 16814777 25644401 details
PTNCTNNB1BioGRID10706604 details
PTNPTPRBBioGRID25644401 details
PTNITGAVBioGRID19141530 details
PTNITGB3BioGRID19141530 details
PTNACTBHPRD9739080 details
PTNSDC1HPRD7592855 details
PTNSDC3HPRD8175719 details
PTNNCANHPRD9507007 details
PTNH2AXIntAct22094255 details
PTNSIRT1IntAct22094255 details
PTNDNMT3BIntAct22094255 details
PTNDNMT1IntAct22094255 details
PTNEZH2IntAct22094255 details