Entity Details

Primary name SPARC
Entity type gene
Source Source Link

Details

PrimaryID6678
RefseqGeneNG_042174
SymbolSPARC
Namesecreted protein acidic and cysteine rich
Chromosome5
Location5q33.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSPRC_HUMAN

GO terms

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GOName
GO:0001503 ossification
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002576 platelet degranulation
GO:0005509 calcium ion binding
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0007507 heart development
GO:0009629 response to gravity
GO:0009986 cell surface
GO:0010288 response to lead ion
GO:0010595 positive regulation of endothelial cell migration
GO:0016363 nuclear matrix
GO:0016525 negative regulation of angiogenesis
GO:0022604 regulation of cell morphogenesis
GO:0030198 extracellular matrix organization
GO:0030324 lung development
GO:0031091 platelet alpha granule
GO:0031092 platelet alpha granule membrane
GO:0031093 platelet alpha granule lumen
GO:0032496 response to lipopolysaccharide
GO:0033591 response to L-ascorbic acid
GO:0034097 response to cytokine
GO:0042060 wound healing
GO:0043231 intracellular membrane-bounded organelle
GO:0043434 response to peptide hormone
GO:0045471 response to ethanol
GO:0046686 response to cadmium ion
GO:0048839 inner ear development
GO:0048856 anatomical structure development
GO:0050807 regulation of synapse organization
GO:0050840 extracellular matrix binding
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0062023 collagen-containing extracellular matrix
GO:0071682 endocytic vesicle lumen
GO:0098978 glutamatergic synapse

Diseases

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Interactions

53 interactions

InteractorPartnerSourcesPublicationsLink
SPARCXRCC6BioGRID, MINT21900206 details
SPARCZNF579BioGRID, MINT21900206 details
SPARCMYOCIntAct20926826 details
SPARCCOL3A1BioGRID, DIP, HPRD19011090 2745554 details
SPARCPCNAUniProt26030842 details
SPARCCOL1A1BioGRID, HPRD, matrixdb26848503 2745554 7034958 details
SPARCCOL5A1BioGRID2745554 details
SPARCVEGFABioGRID, HPRD25921830 9792673 details
SPARCPLGBioGRID, HPRD2745554 7982919 details
SPARCPDGFBBioGRID1311092 details
SPARCUBQLN1BioGRID21852239 details
SPARCCPEB2BioGRID22157746 details
SPARCTNCBioGRID21349332 details
SPARCDISC1IntAct31413325 details
SPARCTGFBIBioGRID23019342 details
SPARCPLATHPRD2745554 details
SPARCPDGFAHPRD1311092 details
SPARCSPARCHPRD2745554 3402455 9233787 details
SPARCTHBS1HPRD2745554 details
SPARCTGFB1HPRD15034927 details
SPARCTGM2HPRD7730416 details
SPARCCTSKHPRD8647860 details
SPARCFN1HPRD2745554 details
SPARCCOL2A1HPRD2745554 details
SPARCCOL1A2HPRD7034958 details
SPARCSDC2HPRD2745554 details
SPARCHSPG2HPRD2745554 details
SPARCPHOSPHO2BioGRID, IntAct30021884 details
SPARCTBC1D14BioGRID, IntAct30021884 details
SPARCILF3BioGRID, IntAct30021884 details
SPARCLSG1BioGRID, IntAct30021884 details
SPARCRASSF7BioGRID26186194 details
SPARCCAPNS1BioGRID31536960 details
SPARCCYB5BBioGRID31536960 details
SPARCFHBioGRID31536960 details
SPARCGPX1BioGRID31536960 details
SPARCHEXABioGRID31536960 details
SPARCLDHABioGRID31536960 details
SPARCNDUFB10BioGRID31536960 details
SPARCACAA2BioGRID31536960 details
SPARCAGMATBioGRID31536960 details
SPARCATF6BioGRID31536960 details
SPARCBCAT1BioGRID31536960 details
SPARCEPHX2BioGRID31536960 details
SPARCFDPSBioGRID31536960 details
SPARCHIBADHBioGRID31536960 details
SPARCIMPDH2BioGRID31536960 details
SPARCNPEPPSBioGRID31536960 details
SPARCSSBP1BioGRID31536960 details
SPARCYWHABBioGRID31536960 details
SPARCYWHAGBioGRID31536960 details
SPARCYWHAQBioGRID31536960 details
SPARCYWHAZBioGRID31536960 details