Entity Details

Primary name TLR3
Entity type gene
Source Source Link

Details

PrimaryID7098
RefseqGeneNG_007278
SymbolTLR3
Nametoll like receptor 3
Chromosome4
Location4q35.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-15
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTLR3_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001774 microglial cell activation
GO:0002224 toll-like receptor signaling pathway
GO:0002730 regulation of dendritic cell cytokine production
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003725 double-stranded RNA binding
GO:0004888 transmembrane signaling receptor activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0006972 hyperosmotic response
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007252 I-kappaB phosphorylation
GO:0008584 male gonad development
GO:0009597 detection of virus
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0032722 positive regulation of chemokine production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034346 positive regulation of type III interferon production
GO:0035458 cellular response to interferon-beta
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035690 cellular response to drug
GO:0036020 endolysosome membrane
GO:0038023 signaling receptor activity
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043331 response to dsRNA
GO:0045087 innate immune response
GO:0045671 negative regulation of osteoclast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0070266 necroptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071360 cellular response to exogenous dsRNA
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097527 necroptotic signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Diseases

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Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
TLR3CHEK2BioGRID, MINT25640309 details
TLR3TLR3DIP, HPRD, IntAct, MINT15107846 18172197 23155421 25217833 details
TLR3SIGLEC5IntAct25187624 details
TLR3SIGLEC6IntAct25187624 details
TLR3SIGLEC7IntAct25187624 details
TLR3SIGLEC9IntAct25187624 details
TLR3SIGLEC10IntAct25187624 details
TLR3SIGLEC11IntAct25187624 details
TLR3RNF216BioGRID, HPRD15107846 details
TLR3MYD88BioGRID, HPRD12646618 details
TLR3MAP2K6BioGRID12609980 details
TLR3TICAM1BioGRID, HPRD12539043 14982987 25736436 27810922 31511519 details
TLR3HLA-DRABioGRID24600555 details
TLR3RNF170BioGRID31076723 details
TLR3TICAM2HPRD14519765 details
TLR3PIK3R1BioGRID, MINT15502848 16858407 details
TLR3SRCMINT16858407 details
TLR3TRILIntAct21911501 details
TLR3MBL2MINT24530528 details
TLR3UNC93B1BioGRID, UniProt22164301 31604943 details
TLR3IRAK2BioGRID17878161 details
TLR3TRIM69BioGRID21911421 details
TLR3TBK1BioGRID21911421 27810922 details
TLR3TRAF6BioGRID, HPRD12609980 16115877 21911421 27810922 details
TLR3MAP3K7BioGRID12609980 16115877 details
TLR3TAB2BioGRID12609980 details
TLR3RIPK1BioGRID16115877 27810922 details
TLR3SYKBioGRID23962979 details
TLR3WDFY1BioGRID25736436 details
TLR3IRGMBioGRID25891078 details
TLR3RNF31BioGRID27810922 details
TLR3SHARPINBioGRID27810922 details
TLR3CASP8BioGRID27810922 details
TLR3FADDBioGRID27810922 details
TLR3RBCK1BioGRID27810922 details
TLR3IKBKGBioGRID27810922 details
TLR3BIRC2BioGRID27810922 details
TLR3BIRC3BioGRID27810922 details
TLR3KCND2BioGRID30758987 details
TLR3KCND3BioGRID30758987 details
TLR3CD14HPRD16473828 details
TLR3CSKHPRD16858407 details
TLR3TOLLIPBioGRID, IntAct21903422 details
TLR3TRAF3BioGRID, IntAct21903422 details
TLR3RNF123BioGRID29676528 details
TLR3NPC1BioGRID33144569 details
TLR3RBM39BioGRID28302793 details
TLR3VIRMABioGRID29507755 details