Entity Details

Primary name TSC2
Entity type gene
Source Source Link

Details

PrimaryID7249
RefseqGeneNG_005895
SymbolTSC2
NameTSC complex subunit 2
Chromosome16
Location16p13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-10-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTSC2_HUMAN

GO terms

Show/Hide Table
GOName
GO:0001843 neural tube closure
GO:0005096 GTPase activator activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006897 endocytosis
GO:0007507 heart development
GO:0008104 protein localization
GO:0008285 negative regulation of cell population proliferation
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0016239 positive regulation of macroautophagy
GO:0019902 phosphatase binding
GO:0030100 regulation of endocytosis
GO:0030178 negative regulation of Wnt signaling pathway
GO:0031267 small GTPase binding
GO:0032007 negative regulation of TOR signaling
GO:0033596 TSC1-TSC2 complex
GO:0042803 protein homodimerization activity
GO:0043276 anoikis
GO:0043491 protein kinase B signaling
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0050918 positive chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051726 regulation of cell cycle
GO:0051879 Hsp90 protein binding
GO:0051898 negative regulation of protein kinase B signaling
GO:1901525 negative regulation of mitophagy

Diseases

Show/Hide Table

Interactions

118 interactions

InteractorPartnerSourcesPublicationsLink
TSC2YWHAZBioGRID, HPRD, MINT12176984 12364343 12438239 12468542 15161933 16636147 20618440 22001647 details
TSC2YWHAGBioGRID, HPRD, IntAct, MINT12364343 12438239 28514442 28561026 details
TSC2SFNHPRD, MINT12364343 12438239 details
TSC2YWHAEBioGRID, HPRD, MINT12438239 17979178 19608861 details
TSC2YWHABBioGRID, HPRD, IntAct, MINT12176984 12364343 12438239 12468542 12582162 15324660 16636147 17353931 20169078 24255178 28514442 details
TSC2YWHAHHPRD, IntAct, MINT12438239 17979178 28514442 details
TSC2YWHAQBioGRID, HPRD, IntAct, MINT12438239 15161933 17353931 20618440 28514442 details
TSC2NEK1BioGRID, HPRD, IntAct14690447 details
TSC2TSC1BioGRID, HPRD, IntAct, MINT, UniProt10585443 10807585 10915759 11175345 11290735 11741832 11741833 12176984 12511557 12869586 14551205 14651849 15340059 15342917 15851026 15851513 15963462 16339216 16424383 16464865 16636147 17077083 17658474 17693255 20166753 20169078 20412061 21134130 25263562 28561026 30514904 9580671 9809973 details
TSC2GRB2BioGRID, IntAct18624398 details
TSC2PIN1BioGRID, MINT21900206 details
TSC2TK1BioGRID, MINT21900206 details
TSC2PPP1CAUniProt19389623 details
TSC2SGK1IntAct27451907 details
TSC2TBC1D7BioGRID, IntAct17658474 26186194 28514442 28561026 details
TSC2TRIM63BioGRID, IntAct31391242 details
TSC2TRIM55BioGRID, IntAct31391242 details
TSC2HTRA1IntAct21622153 details
TSC2RHEBBioGRID, HPRD12771962 12820960 12842888 12869586 15854902 17077083 30514904 details
TSC2FOXO1BioGRID17077083 details
TSC2GSK3BBioGRID, HPRD12511557 16959574 details
TSC2PAMBioGRID, HPRD14559897 details
TSC2PRKAA1BioGRID14651849 15261145 28059666 details
TSC2PTK2BioGRID17043358 details
TSC2RPS6KA1BioGRID, HPRD15342917 15757502 details
TSC2MAPK1BioGRID, HPRD15342917 15851026 details
TSC2UBE3ABioGRID15175323 18298802 details
TSC2FBXW5BioGRID, HPRD18381890 24372178 details
TSC2LNX1BioGRID22889411 details
TSC2CALM1BioGRID11811958 15851513 details
TSC2ESR1BioGRID, HPRD15039427 15851513 details
TSC2SMAD3BioGRID, HPRD15066998 details
TSC2MDFIBioGRID24722188 details
TSC2CBY2BioGRID24722188 details
TSC2PLK2BioGRID20054236 details
TSC2PTPN11BioGRID19299420 details
TSC2SUPT6HBioGRID19299420 details
TSC2RABEP1HPRD9045618 details
TSC2FBXL6HPRD18381890 details
TSC2DAPK1BioGRID, MINT21134130 details
TSC2SIRT1BioGRID, UniProt20169165 details
TSC2CCND1BioGRID, HPRD, IntAct16357142 26977878 details
TSC2CDK4IntAct26977878 details
TSC2CBY1BioGRID, IntAct27173435 unassigned1312 details
TSC2PICK1MINT21653829 details
TSC2USPL1MINT21653829 details
TSC2SSC4DMINT21653829 details
TSC2SLC13A3MINT21653829 details
TSC2SERPINI1MINT21653829 details
TSC2RPSAMINT21653829 details
TSC2RPL4MINT21653829 details
TSC2PHLDB1MINT21653829 details
TSC2MRPL21MINT21653829 details
TSC2MKRN1MINT21653829 details
TSC2GAPDHMINT21653829 details
TSC2ANKRD35MINT21653829 details
TSC2ACTN2MINT21653829 details
TSC2SEPTIN4MINT21653829 details
TSC2RAP1ABioGRID12147258 12842888 details
TSC2RALABioGRID12842888 details
TSC2AKT1BioGRID, HPRD12150915 12438239 15342917 details
TSC2CAV1BioGRID12147258 details
TSC2RAB5ABioGRID, HPRD12147258 9045618 details
TSC2CCND2BioGRID16357142 details
TSC2CCND3BioGRID16357142 details
TSC2PLK1BioGRID16339216 details
TSC2AXIN1BioGRID12511557 details
TSC2HERC1BioGRID16464865 details
TSC2CDKN1BBioGRID, HPRD15355997 17470459 details
TSC2SMAD2BioGRID, HPRD15066998 details
TSC2RRAGABioGRID24529380 25936802 details
TSC2RRAGBBioGRID24529380 details
TSC2RRAGCBioGRID24529380 details
TSC2RRAGDBioGRID24529380 details
TSC2CBLBioGRID20622121 details
TSC2TBK1BioGRID28716898 details
TSC2MAPKAPK2HPRD12582162 details
TSC2AKT2HPRD12167664 details
TSC2AKT3HPRD12167664 details
TSC2PPP2CAHPRD17163575 details
TSC2MAPK3HPRD15342917 details
TSC2P4HA2BioGRID, IntAct28514442 details
TSC2P4HA3BioGRID, IntAct28514442 details
TSC2SIGLECL1BioGRID, IntAct28514442 details
TSC2PNKDBioGRID, IntAct26186194 28514442 details
TSC2RP2BioGRID, IntAct26186194 28514442 details
TSC2CD79BBioGRID, IntAct28514442 details
TSC2COL20A1BioGRID, IntAct28514442 details
TSC2PRKCSHBioGRID, IntAct26186194 28514442 details
TSC2CD83BioGRID, IntAct28514442 details
TSC2FAM221BBioGRID, IntAct28514442 details
TSC2TBC1D7-LOC100130357IntAct28514442 details
TSC2TNFSF13BBioGRID, IntAct30833792 details
TSC2TIGARBioGRID22939629 details
TSC2HECW2BioGRID24163370 details
TSC2CIAO1BioGRID23891004 details
TSC2SPINT2BioGRID26186194 details
TSC2ALDH3A2BioGRID26186194 details
TSC2NTRK1BioGRID25921289 details
TSC2POU5F1BioGRID26687479 details
TSC2RUVBL2BioGRID28561026 details
TSC2TSC2BioGRID28561026 details
TSC2DNAAF10BioGRID28561026 details
TSC2PIH1D1BioGRID28515276 details
TSC2RNF123BioGRID29676528 details
TSC2CTDP1BioGRID31240132 details
TSC2DYRK1ABioGRID30773093 31024071 details
TSC2LMBR1LBioGRID31073040 details
TSC2CBFBBioGRID31253590 details
TSC2PLEKHA4BioGRID31091453 details
TSC2OTULINBioGRID31504727 details
TSC2HAX1BioGRID32877691 details
TSC2LAMP2BioGRID34079125 details
TSC2LAMP3BioGRID34079125 details
TSC2LAMTOR1BioGRID34079125 details
TSC2NUP155BioGRID34079125 details
TSC2RAB9ABioGRID34079125 details
TSC2APEX1BioGRID28986522 details