Entity Details

Primary name NR1H2
Entity type gene
Source Source Link

Details

PrimaryID7376
RefseqGene
SymbolNR1H2
Namenuclear receptor subfamily 1 group H member 2
Chromosome19
Location19q13.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsNR1H2_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0008270 zinc ion binding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010875 positive regulation of cholesterol efflux
GO:0010884 positive regulation of lipid storage
GO:0010887 negative regulation of cholesterol storage
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0031667 response to nutrient levels
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032369 negative regulation of lipid transport
GO:0032376 positive regulation of cholesterol transport
GO:0034191 apolipoprotein A-I receptor binding
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0042632 cholesterol homeostasis
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046965 retinoid X receptor binding
GO:0048384 retinoic acid receptor signaling pathway
GO:0048550 negative regulation of pinocytosis
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0051117 ATPase binding
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0090108 positive regulation of high-density lipoprotein particle assembly
GO:0090187 positive regulation of pancreatic juice secretion
GO:0090340 positive regulation of secretion of lysosomal enzymes
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1903573 negative regulation of response to endoplasmic reticulum stress

Diseases

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Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
NR1H2MDFIBioGRID, HPRD, IntAct16189514 19060904 25416956 32296183 details
NR1H2CIDEAMolecular Connections21315073 details
NR1H2CDKN1ABioGRID, IntAct21988832 details
NR1H2YY1BioGRID, IntAct21988832 details
NR1H2LAMC3BioGRID, IntAct21988832 details
NR1H2NPYBioGRID, IntAct15604093 21988832 32296183 details
NR1H2DUSP12BioGRID, MINT21900206 details
NR1H2CRELD2MINT21900206 details
NR1H2ERG28BioGRID, MINT21900206 details
NR1H2CHD3BioGRID, MINT21900206 details
NR1H2COL4A5BioGRID, MINT21900206 details
NR1H2CSADBioGRID, MINT21900206 details
NR1H2FAF1BioGRID, MINT21900206 details
NR1H2HMGXB4BioGRID, MINT21900206 details
NR1H2MPP1BioGRID, MINT21900206 details
NR1H2RMI1BioGRID, MINT21900206 details
NR1H2ROBO2BioGRID, MINT21900206 details
NR1H2RXRGBioGRID, HPRD, IntAct, MINT15604093 20211142 21900206 25416956 25910212 28514442 31515488 32296183 details
NR1H2SMPD1BioGRID, MINT21900206 details
NR1H2SORBS2BioGRID, MINT21900206 details
NR1H2UBE2D1BioGRID, MINT21900206 details
NR1H2VIMBioGRID, MINT21900206 details
NR1H2SPRY2BioGRID, MINT21900206 details
NR1H2SUV39H1BioGRID, MINT23455924 details
NR1H2KDM1ABioGRID, MINT23455924 details
NR1H2MED1BioGRID, HPRD, IntAct15604093 26120082 details
NR1H2NCOR1BioGRID, HPRD, IntAct12663743 15604093 26120082 details
NR1H2CORO2ABioGRID, DIP21331046 details
NR1H2CAMK2GDIP21331046 details
NR1H2RXRABioGRID, DIP, HPRD, IntAct15604093 15722453 20211142 24561505 7760852 details
NR1H2PPARDBioGRID, DIP15722453 details
NR1H2PPARABioGRID, DIP15722453 details
NR1H2PPARGBioGRID, DIP15722453 details
NR1H2RXRBBioGRID, HPRD, IntAct10187832 15604093 20211142 32296183 details
NR1H2NCOA6BioGRID, HPRD11158331 12724417 15604093 details
NR1H2NR0B2BioGRID, HPRD12198243 27485016 details
NR1H2HDAC4BioGRID17218271 details
NR1H2ZXDCBioGRID, HPRD15604093 details
NR1H2NRIP1BioGRID, HPRD15604093 details
NR1H2NCOR2BioGRID, HPRD15604093 16219912 details
NR1H2NCOA3BioGRID, HPRD15604093 details
NR1H2RARABioGRID, HPRD15604093 details
NR1H2FOXO3BioGRID, HPRD15604093 details
NR1H2SCG5BioGRID15604093 details
NR1H2UBE2IBioGRID, HPRD15604093 details
NR1H2TMEM161ABioGRID, HPRD15604093 details
NR1H2ING3BioGRID, HPRD15604093 details
NR1H2PCDH17BioGRID15604093 details
NR1H2VDRBioGRID, HPRD15604093 details
NR1H2BAG6BioGRID21900206 details
NR1H2PRKCABioGRID18372238 details
NR1H2ACVRL1BioGRID12393874 details
NR1H2NCOA1BioGRID15604093 details
NR1H2RHOUBioGRID26598620 details
NR1H2DNMT3LBioGRID24952347 details
NR1H2ABCA1bhf-ucl, BioGRID20951680 23931754 25838426 details
NR1H2MEN1MINT25962847 details
NR1H2SENP3BioGRID, DIP21331046 details
NR1H2SIRT1BioGRID, HPRD17936707 details
NR1H2SMARCA4BioGRID15774904 details
NR1H2PIAS1BioGRID22969086 27485016 details
NR1H2PPARGC1BBioGRID22969086 details
NR1H2STAT1BioGRID27485016 details
NR1H2NR1H2HPRD12819202 details
NR1H2ABCA12bhf-ucl23931754 details
NR1H2NCOA2DIP24561505 details
NR1H2USP7BioGRID22939629 details
NR1H2PDCD4BioGRID22939629 details
NR1H2LAMTOR5BioGRID30692632 details
NR1H2SREBF1IntAct26120082 details
NR1H2FASNIntAct26120082 details
NR1H2HK1IntAct26120082 details
NR1H2PFKFB1IntAct26120082 details