Entity Details

Primary name MUL1
Entity type gene
Source Source Link

Details

PrimaryID79594
RefseqGene
SymbolMUL1
Namemitochondrial E3 ubiquitin protein ligase 1
Chromosome1
Location1p36.12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-03-12
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMUL1_HUMAN

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0000266 mitochondrial fission
GO:0002039 p53 binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007257 obsolete activation of JUN kinase activity
GO:0010637 negative regulation of mitochondrial fusion
GO:0010821 regulation of mitochondrion organization
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0019789 SUMO transferase activity
GO:0030308 negative regulation of cell growth
GO:0030424 axon
GO:0031307 integral component of mitochondrial outer membrane
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0033235 positive regulation of protein sumoylation
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824 negative regulation of innate immune response
GO:0046872 metal ion binding
GO:0050689 negative regulation of defense response to virus by host
GO:0050821 protein stabilization
GO:0051646 mitochondrion localization
GO:0051881 regulation of mitochondrial membrane potential
GO:0051898 negative regulation of protein kinase B signaling
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061630 ubiquitin protein ligase activity
GO:0071360 cellular response to exogenous dsRNA
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:0090141 positive regulation of mitochondrial fission
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1903861 positive regulation of dendrite extension
GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization

Diseases

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Interactions

69 interactions

InteractorPartnerSourcesPublicationsLink
MUL1APPBP2BioGRID, HPRD, IntAct16189514 19060904 32296183 details
MUL1UBE2D1BioGRID, IntAct19690564 21597459 26018823 28763789 31929179 details
MUL1UBE2D2BioGRID, IntAct18213395 19407830 19690564 28763789 31929179 details
MUL1UBE2D3BioGRID, IntAct19690564 21597459 28763789 31929179 details
MUL1UBE2D4BioGRID, IntAct19690564 28763789 details
MUL1UBE2E1BioGRID, IntAct19690564 28763789 details
MUL1UBE2E3BioGRID, IntAct19690564 25224329 32005965 details
MUL1UBE2L6BioGRID, IntAct19690564 details
MUL1UBE2UBioGRID, IntAct19690564 details
MUL1UBE2WBioGRID, IntAct19690564 details
MUL1SUMO1BioGRID, MINT19407830 details
MUL1UBCBioGRID, MINT19407830 details
MUL1TAP1BioGRID, IntAct21988832 details
MUL1TRIM9BioGRID, IntAct25416956 details
MUL1REEP2BioGRID, IntAct32296183 details
MUL1KRTAP10-8BioGRID, IntAct32296183 details
MUL1DNM1LBioGRID19407830 details
MUL1AKT1BioGRID22410793 details
MUL1TP53BioGRID21597459 31235254 31929179 details
MUL1MUL1BioGRID18213395 31235254 details
MUL1UBE2E2BioGRID25224329 details
MUL1UBE2G2BioGRID25224329 details
MUL1UBE2L3BioGRID25224329 details
MUL1ULK1BioGRID26018823 details
MUL1TP73BioGRID26435500 details
MUL1HTRA2BioGRID24709290 details
MUL1MAP3K7BioGRID27082251 details
MUL1STING1BioGRID28763789 details
MUL1UBE2NBioGRID28763789 details
MUL1CDC34BioGRID28763789 details
MUL1UBE2R2BioGRID28763789 details
MUL1UBE2V2BioGRID28763789 details
MUL1EHD1BioGRID28596240 details
MUL1UBXN7BioGRID32005965 details
MUL1RANGAP1BioGRID32005965 details
MUL1UBE2IBioGRID, MINT19407830 details
MUL1TANKMINT24841215 details
MUL1VPS35BioGRID20619655 details
MUL1VPS26ABioGRID20619655 28596240 details
MUL1MAVSBioGRID23399697 details
MUL1TRAF2BioGRID24841215 details
MUL1GABARAPBioGRID25224329 details
MUL1ATG13BioGRID26018823 details
MUL1ANKFY1BioGRID28596240 details
MUL1VCPBioGRID29599191 details
MUL1HSCBBioGRID, IntAct28380382 details
MUL1SLC39A4BioGRID, IntAct26186194 28514442 details
MUL1SLC39A12BioGRID, IntAct28514442 details
MUL1PPP6R2BioGRID, IntAct28514442 details
MUL1HAUS7BioGRID, IntAct26186194 28514442 details
MUL1CNGA3BioGRID, IntAct28514442 details
MUL1RANBP6BioGRID, IntAct28514442 details
MUL1GSDMEBioGRID, IntAct28514442 details
MUL1ARMC6BioGRID, IntAct28514442 details
MUL1BZW2BioGRID, IntAct28514442 details
MUL1SCN3BBioGRID, IntAct28514442 details
MUL1TRHDEBioGRID, IntAct28514442 details
MUL1PEX19BioGRID, IntAct26186194 28514442 details
MUL1ATRIPBioGRID, IntAct28514442 details
MUL1GUCY1B1BioGRID, IntAct28514442 details
MUL1TBC1D9BioGRID, IntAct28514442 details
MUL1ERAP1BioGRID, IntAct28514442 details
MUL1MAD2L2BioGRID, UniProt29656893 details
MUL1IQCF1BioGRID26186194 details
MUL1SLC25A46BioGRID28057766 details
MUL1LMBR1LBioGRID31073040 details
MUL1PLEKHA4BioGRID31091453 details
MUL1AKAP1BioGRID34079125 details
MUL1DDX58BioGRID32513696 details