Entity Details

Primary name TNFSF10
Entity type gene
Source Source Link

Details

PrimaryID8743
RefseqGene
SymbolTNFSF10
NameTNF superfamily member 10
Chromosome3
Location3q26.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-11
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsTNF10_HUMAN

GO terms

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GOName
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008270 zinc ion binding
GO:0008584 male gonad development
GO:0032868 response to insulin
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045569 TRAIL binding
GO:0070062 extracellular exosome
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
TNFSF10TNFRSF10BBioGRID, HPRD, IntAct, MINT10542098 10549288 10894160 11094155 16554480 19427028 19432816 20097879 20103630 21459798 21525171 21822306 22266862 22585859 23678861 25551360 9311998 9325248 details
TNFSF10TNFRSF10ABioGRID, HPRD, IntAct, MINT10549288 10894160 19427028 20103630 9082980 9325248 details
TNFSF10RBM48BioGRID, HPRD, IntAct16169070 details
TNFSF10ACP5BioGRID, HPRD, IntAct16169070 details
TNFSF10IER3IntAct15451437 details
TNFSF10TNFRSF10DBioGRID, HPRD, IntAct20103630 9430226 details
TNFSF10TNFRSF10CHPRD, IntAct20103630 9314565 9325248 9613612 details
TNFSF10ZDHHC17BioGRID, IntAct24705354 details
TNFSF10CASP3BioGRID23703388 details
TNFSF10FADDBioGRID, DIP, IntAct, MINT10894160 12198154 16554480 16801533 19427028 19432816 20097879 21459798 21525171 21822306 22266862 22585859 23678861 25551360 details
TNFSF10CASP8BioGRID, DIP, IntAct, MINT10894160 12198154 16554480 16801533 19427028 19432816 20097879 21459798 21525171 21822306 22266862 22585859 23142077 23678861 24287696 25551360 details
TNFSF10CUL3BioGRID, IntAct19427028 25551360 details
TNFSF10CFLARBioGRID, IntAct, MINT19432816 20097879 21459798 21525171 21822306 22266862 23678861 details
TNFSF10TNFSF10BioGRID, HPRD10549288 10651627 details
TNFSF10SOCS3BioGRID21308719 details
TNFSF10RIPK1BioGRID19432816 22585859 details
TNFSF10TNFAIP3BioGRID22585859 details
TNFSF10TRAF2BioGRID22585859 details
TNFSF10PPP2CABioGRID25551360 details
TNFSF10PEA15BioGRID19432816 details
TNFSF10TNFRSF11BHPRD12221720 9520411 details
TNFSF10CASP10IntAct, MINT12198154 23678861 details
TNFSF10PAK1IntAct25843002 details
TNFSF10FOXO3IntAct27451907 details
TNFSF10HHEXIntAct33179750 details
TNFSF10IRF2IntAct33179750 details
TNFSF10ZNF710IntAct33179750 details
TNFSF10WT1IntAct33179750 details
TNFSF10SP4IntAct33179750 details
TNFSF10SOX14IntAct33179750 details
TNFSF10NR5A2IntAct33179750 details
TNFSF10MAZIntAct33179750 details
TNFSF10KLF7IntAct33179750 details
TNFSF10KLF4IntAct33179750 details
TNFSF10KLF3IntAct33179750 details
TNFSF10KLF2IntAct33179750 details
TNFSF10KLF17IntAct33179750 details
TNFSF10KLF15IntAct33179750 details
TNFSF10IRX5IntAct33179750 details
TNFSF10IRF8IntAct33179750 details