Entity Details

Primary name NRP1
Entity type gene
Source Source Link

Details

PrimaryID8829
RefseqGeneNG_030328
SymbolNRP1
Nameneuropilin 1
Chromosome10
Location10p11.22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-23
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsNRP1_HUMAN

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001764 neuron migration
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002116 semaphorin receptor complex
GO:0003148 outflow tract septum morphogenesis
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005096 GTPase activator activity
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0008201 heparin binding
GO:0009611 response to wounding
GO:0009887 animal organ morphogenesis
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0017154 semaphorin receptor activity
GO:0019838 growth factor binding
GO:0019955 cytokine binding
GO:0021675 nerve development
GO:0030424 axon
GO:0030426 growth cone
GO:0031290 retinal ganglion cell axon guidance
GO:0031410 cytoplasmic vesicle
GO:0031532 actin cytoskeleton reorganization
GO:0031966 mitochondrial membrane
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035767 endothelial cell chemotaxis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038085 vascular endothelial growth factor binding
GO:0038189 neuropilin signaling pathway
GO:0038190 VEGF-activated neuropilin signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0043542 endothelial cell migration
GO:0046718 viral entry into host cell
GO:0046872 metal ion binding
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048844 artery morphogenesis
GO:0048846 axon extension involved in axon guidance
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0051491 positive regulation of filopodium assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0060301 positive regulation of cytokine activity
GO:0060385 axonogenesis involved in innervation
GO:0060627 regulation of vesicle-mediated transport
GO:0060978 angiogenesis involved in coronary vascular morphogenesis
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0061549 sympathetic ganglion development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071526 semaphorin-plexin signaling pathway
GO:0071679 commissural neuron axon guidance
GO:0090259 regulation of retinal ganglion cell axon guidance
GO:0097102 endothelial tip cell fate specification
GO:0097443 sorting endosome
GO:0097475 motor neuron migration
GO:0097490 sympathetic neuron projection extension
GO:0097491 sympathetic neuron projection guidance
GO:0150018 basal dendrite development
GO:0150020 basal dendrite arborization
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901166 neural crest cell migration involved in autonomic nervous system development
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902336 positive regulation of retinal ganglion cell axon guidance
GO:1902946 protein localization to early endosome
GO:2000251 positive regulation of actin cytoskeleton reorganization

Diseases

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Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
NRP1VEGFABioGRID, HPRD, IntAct, MINT10409677 11886873 11986311 16423422 16763549 17222790 18325345 20363638 21939755 22318724 22897854 26804163 30236477 9529250 details
NRP1RPL27BioGRID, IntAct21988832 details
NRP1FLNAMINT24021649 details
NRP1PGFBioGRID, HPRD11986311 details
NRP1VEGFBBioGRID, HPRD10409677 details
NRP1TGFBR2BioGRID20675371 21186301 details
NRP1TGFBR1BioGRID20675371 21186301 details
NRP1L1CAMBioGRID16377081 25315821 details
NRP1TGFBR3BioGRID21186301 details
NRP1PLXNA1BioGRID, HPRD10520994 11239433 11886873 25315821 details
NRP1NRP1BioGRID, HPRD25315821 9856463 details
NRP1NRP2BioGRID, HPRD25315821 9856463 details
NRP1PLXNB1BioGRID25315821 details
NRP1SEMA3ABioGRID, HPRD10520994 11886873 9331348 details
NRP1FGF2BioGRID, HPRD15695515 30236477 details
NRP1KDRBioGRID, HPRD, IntAct, MINT11333271 11886873 11948691 16763549 17222790 19857463 26037503 details
NRP1FLT1HPRD, IntAct10842181 23452854 details
NRP1ITGA5DIP19175293 details
NRP1PLXNA2DIP19243221 details
NRP1SRRM1BioGRID16159877 details
NRP1PLVAPBioGRID22627768 details
NRP1PDGFBBioGRID16847823 20577048 details
NRP1ITGA6BioGRID29755126 details
NRP1GIPC1BioGRID, HPRD10414980 15978582 27481513 29755126 details
NRP1PLXND1BioGRID26037503 details
NRP1SEMA3FHPRD9883722 details
NRP1SEMA3BHPRD10196546 details
NRP1FGF4HPRD15695515 details
NRP1FGF7HPRD15695515 details
NRP1SEMA3CHPRD9331348 details
NRP1FGF1HPRD15695515 details
NRP1FGFR1HPRD15695515 details
NRP1CSNK2A2BioGRID, IntAct23455922 28514442 details
NRP1TMPRSS11BBioGRID, IntAct28514442 details
NRP1EVA1CBioGRID, IntAct26186194 28514442 details
NRP1ST8SIA4BioGRID, IntAct28514442 details
NRP1EDNRBBioGRID, IntAct28514442 details
NRP1GINM1BioGRID, IntAct26186194 28514442 details
NRP1TNFBioGRID, IntAct26186194 28514442 details
NRP1ICAM2BioGRID, IntAct26186194 28514442 details
NRP1GPR183BioGRID, IntAct26186194 28514442 details
NRP1IL27RABioGRID, IntAct28514442 details
NRP1TAFA4BioGRID, IntAct28514442 details
NRP1PIP5K1ABioGRID, IntAct26186194 28514442 details
NRP1TMX1BioGRID, IntAct28514442 details
NRP1FZD10BioGRID, IntAct28514442 details
NRP1LIPGBioGRID, IntAct28514442 details
NRP1BCS1LBioGRID, IntAct28514442 details
NRP1KCTD10BioGRID, IntAct28514442 details
NRP1UBR2BioGRID, IntAct28514442 details
NRP1UBR1BioGRID, IntAct28514442 details
NRP1KCTD9BioGRID, IntAct28514442 details
NRP1UBR4BioGRID, IntAct28514442 details
NRP1ODF2BioGRID, IntAct28514442 details
NRP1TNFAIP1BioGRID, IntAct28514442 details
NRP1NSUN2BioGRID, IntAct28514442 details
NRP1CSNK2A1BioGRID, IntAct28514442 details
NRP1NCLBioGRID, IntAct30021884 details
NRP1CD81IntAct32900848 details
NRP1CCDC8BioGRID24711643 details
NRP1TMEM30ABioGRID26186194 details
NRP1AGERBioGRID26186194 details
NRP1HNRNPDBioGRID26496610 details
NRP1PYHIN1BioGRID28077445 details
NRP1ESR2BioGRID29509190 details
NRP1CA9BioGRID28692057 details
NRP1RETBioGRID32062451 details
NRP1SEC61BBioGRID34079125 details
NRP1HNRNPLBioGRID28611215 details
NRP1VIRMABioGRID29507755 details