Entity Details

Primary name CRUM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5IJ48
EntryNameCRUM2_HUMAN
FullNameProtein crumbs homolog 2
TaxID9606
Evidenceevidence at protein level
Length1285
SequenceStatuscomplete
DateCreated2005-07-19
DateModified2021-06-02

Ontological Relatives

GenesCRB2

GO terms

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GOName
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0001895 retina homeostasis
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007601 visual perception
GO:0010470 regulation of gastrulation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010951 negative regulation of endopeptidase activity
GO:0014028 notochord formation
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0030010 establishment of cell polarity
GO:0030054 cell junction
GO:0030513 positive regulation of BMP signaling pathway
GO:0032991 protein-containing complex
GO:0044877 protein-containing complex binding
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0045494 photoreceptor cell maintenance
GO:0046549 retinal cone cell development
GO:0050896 response to stimulus
GO:0055111 ingression involved in gastrulation with mouth forming second
GO:0070062 extracellular exosome
GO:0072359 circulatory system development

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell junction
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001791 Laminin G domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site

Diseases

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Interactions

4 interactions