Entity Details

Primary name ROCK2
Entity type gene
Source Source Link

Details

PrimaryID9475
RefseqGeneNG_029769
SymbolROCK2
NameRho associated coiled-coil containing protein kinase 2
Chromosome2
Location2p25.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-04-13
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsROCK2_HUMAN

GO terms

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GOName
GO:0000281 mitotic cytokinesis
GO:0001837 epithelial to mesenchymal transition
GO:0001934 positive regulation of protein phosphorylation
GO:0002931 response to ischemia
GO:0003180 aortic valve morphogenesis
GO:0003723 RNA binding
GO:0004674 protein serine/threonine kinase activity
GO:0005198 structural molecule activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006939 smooth muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007266 Rho protein signal transduction
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010825 positive regulation of centrosome duplication
GO:0016525 negative regulation of angiogenesis
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0030155 regulation of cell adhesion
GO:0030335 positive regulation of cell migration
GO:0030866 cortical actin cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0031267 small GTPase binding
GO:0031644 regulation of nervous system process
GO:0032723 positive regulation of connective tissue growth factor production
GO:0032956 regulation of actin cytoskeleton organization
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0039694 viral RNA genome replication
GO:0042752 regulation of circadian rhythm
GO:0043410 positive regulation of MAPK cascade
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045616 regulation of keratinocyte differentiation
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048156 tau protein binding
GO:0048511 rhythmic process
GO:0048598 embryonic morphogenesis
GO:0050321 tau-protein kinase activity
GO:0051246 regulation of protein metabolic process
GO:0051298 centrosome duplication
GO:0051492 regulation of stress fiber assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051893 regulation of focal adhesion assembly
GO:0061157 mRNA destabilization
GO:0070168 negative regulation of biomineral tissue development
GO:0071394 cellular response to testosterone stimulus
GO:0071559 response to transforming growth factor beta
GO:0072518 Rho-dependent protein serine/threonine kinase activity
GO:0072659 protein localization to plasma membrane
GO:0090271 positive regulation of fibroblast growth factor production
GO:0097746 blood vessel diameter maintenance
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110061 regulation of angiotensin-activated signaling pathway
GO:0150033 negative regulation of protein localization to lysosome
GO:1900037 regulation of cellular response to hypoxia
GO:1901888 regulation of cell junction assembly
GO:1902004 positive regulation of amyloid-beta formation
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 positive regulation of protein localization to early endosome
GO:1902993 positive regulation of amyloid precursor protein catabolic process
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1905145 cellular response to acetylcholine
GO:1905205 positive regulation of connective tissue replacement
GO:1990776 response to angiotensin
GO:2000114 regulation of establishment of cell polarity
GO:2000145 regulation of cell motility

Diseases

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Interactions

84 interactions

InteractorPartnerSourcesPublicationsLink
ROCK2PPP1R14BMINT17022978 details
ROCK2APPIntAct32814053 details
ROCK2MAGEC1BioGRID, HPRD17137291 details
ROCK2CDKN3BioGRID24704824 details
ROCK2MYL2BioGRID25412762 details
ROCK2PTPRFBioGRID25458010 details
ROCK2NCLMINT21281639 details
ROCK2LZTFL1BioGRID, IntAct27173435 unassigned1312 details
ROCK2STAT3IntAct30413785 details
ROCK2EP300IntAct30413785 details
ROCK2JAK3IntAct30413785 details
ROCK2JAK2IntAct30413785 details
ROCK2RHOABioGRID11350930 details
ROCK2BRCA2BioGRID21084279 details
ROCK2RHOBTB1BioGRID31431478 details
ROCK2PPP1R12AHPRD10601309 11931630 12220642 12563012 12600888 details
ROCK2STAU1HPRD, IntAct15121898 details
ROCK2STK16BioGRID, IntAct17353931 details
ROCK2IKBKEBioGRID, IntAct17353931 details
ROCK2NFKBIAIntAct12730857 details
ROCK2SNW1BioGRID, MINT20467437 details
ROCK2CDC5LBioGRID, MINT20467437 details
ROCK2FLOT2I2D22056876 details
ROCK2SPHK1IntAct25216046 details
ROCK2KSR2IntAct27086506 details
ROCK2DNAJB11BioGRID, IntAct26186194 28514442 details
ROCK2FBXO42BioGRID, IntAct28514442 details
ROCK2ROCK1BioGRID, IntAct28514442 details
ROCK2POLR1CBioGRID, IntAct28514442 details
ROCK2LRPAP1BioGRID, IntAct28514442 details
ROCK2ADD2BioGRID, IntAct28514442 details
ROCK2LAMP1BioGRID, IntAct29568061 34079125 details
ROCK2H2BC21BioGRID, IntAct30021884 details
ROCK2HNRNPCL2BioGRID, IntAct30021884 details
ROCK2LRRK2IntAct31046837 details
ROCK2PDPK1BioGRID, IntAct31980649 details
ROCK2WASHC5BioGRID22863883 details
ROCK2RABGEF1BioGRID22863883 details
ROCK2WASHC2ABioGRID22863883 details
ROCK2GPHNBioGRID22863883 details
ROCK2LMNABioGRID22863883 details
ROCK2MTA2BioGRID22863883 details
ROCK2SNU13BioGRID22863883 details
ROCK2ZW10BioGRID22863883 details
ROCK2RACGAP1BioGRID26344197 details
ROCK2NTRK1BioGRID25921289 details
ROCK2CYLDBioGRID27591049 details
ROCK2TRIP4BioGRID27684187 details
ROCK2EFTUD2BioGRID28515276 details
ROCK2HRASBioGRID30442766 details
ROCK2KRASBioGRID30442766 30639242 34079125 details
ROCK2NRASBioGRID30442766 30639242 details
ROCK2KCNJ2BioGRID29549164 details
ROCK2VIRMABioGRID29507755 details
ROCK2DCAF15BioGRID31452512 details
ROCK2MDP1BioGRID28675297 details
ROCK2ABCC6BioGRID29704455 details
ROCK2PLEKHA4BioGRID31091453 details
ROCK2ARF6BioGRID34079125 details
ROCK2GJA1BioGRID34079125 details
ROCK2LAMP2BioGRID34079125 details
ROCK2LAMP3BioGRID34079125 details
ROCK2LAMTOR1BioGRID34079125 details
ROCK2MAPRE3BioGRID34079125 details
ROCK2PRPHBioGRID34079125 details
ROCK2RAB11ABioGRID34079125 details
ROCK2RAB2ABioGRID34079125 details
ROCK2RHOBBioGRID34079125 details
ROCK2PRKDCIntAct26175416 details
ROCK2PRDM1IntAct30413785 details
ROCK2TXLNAIntAct30413785 details
ROCK2BCL6IntAct30413785 details
ROCK2IRF4IntAct30413785 details
ROCK2TOB1IntAct30413785 details
ROCK2BATFIntAct30413785 details
ROCK2ICOSIntAct30413785 details
ROCK2MAFIntAct30413785 details
ROCK2BCL9LIntAct30413785 details
ROCK2CXCR5IntAct30413785 details
ROCK2RTP5IntAct30413785 details
ROCK2PDCD1IntAct30413785 details
ROCK2RORCIntAct30413785 details
ROCK2ELAVL1BioGRID19322201 details
ROCK2APEX1BioGRID28986522 details