Entity Details

Primary name CD40
Entity type gene
Source Source Link

Details

PrimaryID958
RefseqGeneNG_007279
SymbolCD40
NameCD40 molecule
Chromosome20
Location20q13.12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-17
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsTNR5_HUMAN

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0003823 antigen binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0019724 B cell mediated immunity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0023035 CD40 signaling pathway
GO:0030168 platelet activation
GO:0030890 positive regulation of B cell proliferation
GO:0031625 ubiquitin protein ligase binding
GO:0032735 positive regulation of interleukin-12 production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033590 response to cobalamin
GO:0034341 response to interferon-gamma
GO:0035631 CD40 receptor complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0036018 cellular response to erythropoietin
GO:0038023 signaling receptor activity
GO:0042100 B cell proliferation
GO:0042113 B cell activation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042832 defense response to protozoan
GO:0043025 neuronal cell body
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043196 varicosity
GO:0043231 intracellular membrane-bounded organelle
GO:0043406 positive regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043547 positive regulation of GTPase activity
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050776 regulation of immune response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0090037 positive regulation of protein kinase C signaling
GO:1901652 response to peptide
GO:2000353 positive regulation of endothelial cell apoptotic process

Diseases

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Interactions

75 interactions

InteractorPartnerSourcesPublicationsLink
CD40TRAF3BioGRID, HPRD, IntAct10352240 10984535 11562359 12220533 12637493 14517219 16260598 17878343 19667091 20614026 21041727 24260396 24810049 26779844 27716849 32041822 7527023 7530216 7533327 7859281 9168896 9384571 9718306 9990007 details
CD40TRAF6BioGRID, HPRD, InnateDB, IntAct10075662 10411888 12140561 12220533 12637493 16260598 20449947 20614026 20676093 21041727 24812060 9384571 9718306 9990007 details
CD40TRAF2BioGRID, HPRD, InnateDB, IntAct10352240 10411888 11562359 12220533 12637493 16260598 17353931 19667091 20449947 20614026 20676093 21041727 21071692 21282461 25416956 25502805 25910212 27716849 31515488 32041822 32296183 9020361 9168896 9718306 9990007 details
CD40TRAF5BioGRID, HPRD, InnateDB11562359 12220533 20614026 20676093 21041727 26779844 8790348 9511754 9990007 details
CD40MIPBioGRID, IntAct32296183 details
CD40MFSD5BioGRID, IntAct32296183 details
CD40TMEM147BioGRID, IntAct32296183 details
CD40SLC39A13BioGRID, IntAct32296183 details
CD40TLCD1BioGRID, IntAct32296183 details
CD40CYB561A3BioGRID, IntAct32296183 details
CD40CMTM6BioGRID, IntAct32296183 details
CD40INSIG2BioGRID, IntAct32296183 details
CD40TMEM128BioGRID, IntAct32296183 details
CD40SLC7A1BioGRID, IntAct32296183 details
CD40PLP1BioGRID, IntAct32296183 details
CD40TMEM107BioGRID, IntAct32296183 details
CD40EBPBioGRID, IntAct32296183 details
CD40MALBioGRID, IntAct32296183 details
CD40CMTM5BioGRID, IntAct32296183 details
CD40DEFB121BioGRID, IntAct32296183 details
CD40SLC30A3BioGRID, IntAct32296183 details
CD40SLC30A2BioGRID, IntAct32296183 details
CD40NCOA6BioGRID10847592 details
CD40TDP2BioGRID, HPRD10764746 details
CD40XRCC6BioGRID, HPRD10514012 details
CD40XRCC5BioGRID, HPRD10514012 details
CD40HSPA4BioGRID, HPRD12356871 details
CD40TANKBioGRID17878343 26779844 details
CD40FAF1BioGRID24810049 details
CD40PSMD1IntAct17353931 details
CD40PCMT1IntAct17353931 details
CD40MYCBPIntAct17353931 details
CD40KATNA1IntAct17353931 details
CD40OGTIntAct17353931 details
CD40RIPK2BioGRID, HPRD9642260 details
CD40MS4A1BioGRID, HPRD9933087 details
CD40TRAF3IP2BioGRID, HPRD12089335 15485634 24120361 details
CD40TRAF1BioGRID, HPRD10411888 20614026 7527023 9718306 details
CD40BIRC2BioGRID, HPRD11562359 20614026 21041727 details
CD40TRAF4BioGRID11562359 details
CD40PIK3CABioGRID12637493 details
CD40CBLBioGRID, HPRD12637493 details
CD40MAP3K8BioGRID, HPRD15670770 details
CD40IL4RBioGRID, HPRD12207328 details
CD40CD40LGBioGRID, HPRD10647992 23918987 7516405 7543281 details
CD40PIK3R1BioGRID, HPRD12637493 21200133 details
CD40CHUKBioGRID20614026 details
CD40DIABLOBioGRID20614026 details
CD40CD40BioGRID20614026 details
CD40IKBKBBioGRID20614026 details
CD40RNF31BioGRID20614026 details
CD40HTRA2BioGRID20614026 details
CD40STING1BioGRID27716849 details
CD40MAP3K1BioGRID32041822 details
CD40IKBKGBioGRID32041822 details
CD40NSMAFHPRD10601289 details
CD40CAV1HPRD14665433 details
CD40BIRC3HPRD11562359 details
CD40HSPA8HPRD12356871 details
CD40JAK3HPRD10395671 9133417 details
CD40TXNBioGRID, IntAct17353931 details
CD40SLC39A7BioGRID, IntAct17353931 details
CD40USP15BioGRID, IntAct17353931 details
CD40UGGT1BioGRID, IntAct17353931 details
CD40SGK1BioGRID, IntAct17353931 details
CD40SLC30A7BioGRID, IntAct17353931 details
CD40FBLBioGRID, IntAct17353931 details
CD40RFC5BioGRID, IntAct17353931 details
CD40POLR2HBioGRID, IntAct17353931 details
CD40ERP44BioGRID, IntAct17353931 details
CD40CALRBioGRID, IntAct17353931 details
CD40DDX3XBioGRID17353931 details
CD40OBI1BioGRID17353931 details
CD40BAG3BioGRID23824909 details
CD40RNF4BioGRID29180619 details