Entity Details

Primary name PADI6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6TGC4
EntryNamePADI6_HUMAN
FullNameProtein-arginine deiminase type-6
TaxID9606
Evidenceevidence at protein level
Length694
SequenceStatuscomplete
DateCreated2004-12-21
DateModified2021-06-02

Ontological Relatives

GenesPADI6

GO terms

Show/Hide Table
GOName
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0007010 cytoskeleton organization
GO:0007028 cytoplasm organization
GO:0030133 transport vesicle
GO:0036414 histone citrullination
GO:0040016 embryonic cleavage
GO:0043143 regulation of translation by machinery localization
GO:0045111 intermediate filament cytoskeleton
GO:0060473 cortical granule

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR004303 Protein-arginine deiminaseFamilyFamily
IPR008972 CupredoxinFamilyHomologous superfamily
IPR013530 Protein-arginine deiminase, C-terminalDomainDomain
IPR013732 Protein-arginine deiminase (PAD), N-terminalDomainDomain
IPR013733 Protein-arginine deiminase (PAD), central domainDomainDomain
IPR036556 Protein-arginine deiminase, central domain superfamilyFamilyHomologous superfamily
IPR038685 PAD, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
617234 OMIMPreimplantation embryonic lethality 2 (PREMBL2)A rare cause of female primary infertility. In affected women, ovulation and fertilization proceed normally but embryos are arrested at early stages of development. Inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00155 CitrullineDrugbanksmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
PADI6_HUMANZN526_HUMANBioGRID, IntAct32296183 details
PADI6_HUMANDDT4L_HUMANIntAct32296183 details
PADI6_HUMANSUV91_HUMANBioGRID, IntAct32296183 details
PADI6_HUMANKLHL2_HUMANBioGRID, IntAct32296183 details