Entity Details

Primary name HUWE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7Z6Z7
EntryNameHUWE1_HUMAN
FullNameE3 ubiquitin-protein ligase HUWE1
TaxID9606
Evidenceevidence at protein level
Length4374
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesHUWE1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000209 protein polyubiquitination
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006284 base-excision repair
GO:0006513 protein monoubiquitination
GO:0007030 Golgi organization
GO:0010637 negative regulation of mitochondrial fusion
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0016574 histone ubiquitination
GO:0030154 cell differentiation
GO:0031398 positive regulation of protein ubiquitination
GO:0032922 circadian regulation of gene expression
GO:0034774 secretory granule lumen
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043312 neutrophil degranulation
GO:0045732 positive regulation of protein catabolic process
GO:0061025 membrane fusion
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000569 HECT domainDomainDomain
IPR004170 WWE domainDomainDomain
IPR009060 UBA-like superfamilyFamilyHomologous superfamily
IPR010309 E3 ubiquitin ligase, domain of unknown function DUF908DomainDomain
IPR010314 E3 ubiquitin ligase, domain of unknown function DUF913DomainDomain
IPR015940 Ubiquitin-associated domainDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR025527 HUWE1/Rev1, ubiquitin binding regionRepeatRepeat
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR037197 WWE domain superfamilyFamilyHomologous superfamily
IPR041918 HUWE1, UBA domainDomainDomain

Diseases

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Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
HUWE1_HUMANARF_HUMANBioGRID, HPRD, IntAct, UniProt15989956 22561347 26212014 26496610 28193319 details
HUWE1_HUMANP53_HUMANBioGRID, HPRD, UniProt15989956 22552282 31570706 details
HUWE1_HUMANMCL1_HUMANBioGRID, DIP, HPRD, MINT, Molecular Connections15989957 16213503 19148187 20007713 20023629 21298030 21507240 21613222 21730980 21907705 22552282 25147182 27517746 28193319 29799788 32378766 details
HUWE1_HUMANMYC_HUMANBioGRID, IntAct16269333 17314511 18488021 26279298 29467282 31677785 details
HUWE1_HUMANUB2E3_HUMANIntAct19549727 details
HUWE1_HUMANUBP7_HUMANBioGRID, IntAct19615732 25147182 26496610 27934968 details
HUWE1_HUMANUBP4_HUMANBioGRID, MINT21522127 details
HUWE1_HUMANHSPB1_HUMANBioGRID, IntAct25147182 25277244 details
HUWE1_HUMANTNS2_HUMANBioGRID, IntAct25814554 details
HUWE1_HUMANCALR_HUMANBioGRID, IntAct25147182 32814053 details
HUWE1_HUMANCADH1_HUMANIntAct32814053 details
HUWE1_HUMANODO2_HUMANIntAct32814053 details
HUWE1_HUMANNEK7_HUMANIntAct32814053 details
HUWE1_HUMANCDC6_HUMANBioGRID17567951 details
HUWE1_HUMANHUWE1_HUMANBioGRID15989956 20007713 26212014 26949039 28193319 28425671 29964046 details
HUWE1_HUMANCDN2A_HUMANBioGRID15989956 22561347 26212014 26496610 28193319 details
HUWE1_HUMANDPOLB_HUMANBioGRID19713937 details
HUWE1_HUMANPIAS2_HUMANBioGRID20624960 details
HUWE1_HUMANCALM1_HUMANBioGRID15840729 details
HUWE1_HUMANCALM2_HUMANBioGRID15840729 details
HUWE1_HUMANCALM3_HUMANBioGRID15840729 details
HUWE1_HUMANPCNA_HUMANBioGRID22203964 25147182 27146073 details
HUWE1_HUMANHDAC2_HUMANBioGRID22016339 details
HUWE1_HUMANABL1_HUMANBioGRID7968380 details
HUWE1_HUMANUB2L3_HUMANBioGRID19713937 20007713 23652204 25723849 27146073 29643511 29964046 9575161 details
HUWE1_HUMANUB2D1_HUMANBioGRID15989956 16269333 18488021 22016339 25723849 26212014 9575161 details
HUWE1_HUMANUB2G1_HUMANBioGRID22016339 details
HUWE1_HUMANUB2D2_HUMANBioGRID16213503 25723849 26393420 26949039 29643511 details
HUWE1_HUMANUB2D3_HUMANBioGRID20624960 25723849 details
HUWE1_HUMANUBC_HUMANBioGRID17550899 23314748 25147182 25723849 28190767 28943312 31699778 details
HUWE1_HUMANMUTYH_HUMANBioGRID24443563 details
HUWE1_HUMANSHOC2_HUMANBioGRID25022756 26519477 details
HUWE1_HUMANCTNB1_HUMANBioGRID25147182 27684187 28137882 details
HUWE1_HUMANRBBP7_HUMANBioGRID25147182 29738775 details
HUWE1_HUMANWIPI2_HUMANBioGRID25147182 30340022 details
HUWE1_HUMANMYOD1_HUMANBioGRID22277673 details
HUWE1_HUMANZBT17_HUMANBioGRID16269333 26212014 details
HUWE1_HUMANTBP_HUMANBioGRID26393420 details
HUWE1_HUMANDPOLL_HUMANBioGRID22370481 details
HUWE1_HUMANCUL4B_HUMANBioGRID25883150 details
HUWE1_HUMANH2AX_HUMANBioGRID27146073 details
HUWE1_HUMANMYCN_HUMANBioGRID18488021 details
HUWE1_HUMANKLF4_HUMANBioGRID28084302 details
HUWE1_HUMANATOH1_HUMANBioGRID27542412 details
HUWE1_HUMANWBP2_HUMANBioGRID27578003 details
HUWE1_HUMANERG_HUMANBioGRID27626314 details
HUWE1_HUMANPPP5_HUMANBioGRID23652204 details
HUWE1_HUMANMDM2_HUMANBioGRID23652204 30818224 details
HUWE1_HUMANSUMO2_HUMANBioGRID32786267 details
HUWE1_HUMANRNF11_HUMANBioGRID, HPRD15231748 31985874 details
HUWE1_HUMANCBP_HUMANBioGRID32238831 details
HUWE1_HUMANCASP1_HUMANBioGRID33099407 details
HUWE1_HUMANSMAD9_HUMANHPRD15231748 details
HUWE1_HUMANLAPM5_HUMANHPRD15231748 details
HUWE1_HUMANSMAD2_HUMANHPRD15231748 details
HUWE1_HUMANTFCP2_HUMANIntAct20195357 details
HUWE1_HUMANKAP0_HUMANIntAct20195357 details
HUWE1_HUMANUSP9X_HUMANBioGRID, DIP20023629 21907705 details
HUWE1_HUMANNR1D1_HUMANBioGRID, DIP20534529 details
HUWE1_HUMANDISC1_HUMANIntAct31413325 details
HUWE1_HUMANATM_HUMANBioGRID17478428 22213803 details
HUWE1_HUMANCK5P3_HUMANBioGRID20164180 details
HUWE1_HUMANAPR_HUMANBioGRID21907705 details
HUWE1_HUMANRD23A_HUMANBioGRID19013454 details
HUWE1_HUMANH2B3B_HUMANBioGRID21846774 details
HUWE1_HUMANRASF1_HUMANBioGRID21910689 details
HUWE1_HUMANMFN2_HUMANBioGRID22748923 30217973 details
HUWE1_HUMANHSP74_HUMANBioGRID21298030 25147182 details
HUWE1_HUMANLIMC1_HUMANBioGRID22939629 31279706 details
HUWE1_HUMANEFMT3_HUMANBioGRID23349634 details
HUWE1_HUMANBRCA1_HUMANBioGRID24342616 details
HUWE1_HUMANDVL3_HUMANBioGRID24643799 details
HUWE1_HUMANDVL1_HUMANBioGRID24643799 details
HUWE1_HUMANEGFR_HUMANBioGRID24797263 32017279 details
HUWE1_HUMANSPRTN_HUMANBioGRID23254330 details
HUWE1_HUMANRASM_HUMANBioGRID25022756 details
HUWE1_HUMANRAF1_HUMANBioGRID25022756 details
HUWE1_HUMANDDB1_HUMANBioGRID25147182 25883150 details
HUWE1_HUMANDDIT4_HUMANBioGRID25147182 details
HUWE1_HUMANPSDE_HUMANBioGRID24743594 25147182 details
HUWE1_HUMANFBW1B_HUMANBioGRID25515538 details
HUWE1_HUMANKDM3A_HUMANBioGRID26279298 details
HUWE1_HUMANPSMD4_HUMANBioGRID23209776 details
HUWE1_HUMANBAG6_HUMANBioGRID24981174 details
HUWE1_HUMANVHL_HUMANBioGRID27517496 details
HUWE1_HUMANSCNNA_HUMANBioGRID28137758 details
HUWE1_HUMANDERL1_HUMANBioGRID28137758 details
HUWE1_HUMANPREX2_HUMANBioGRID28205209 30796242 details
HUWE1_HUMANGNMT_HUMANBioGRID28205209 details
HUWE1_HUMANSMU1_HUMANBioGRID29507117 details
HUWE1_HUMANAMRA1_HUMANBioGRID30217973 details
HUWE1_HUMANFGF11_HUMANBioGRID28027390 details
HUWE1_HUMANTXNIP_HUMANBioGRID29378950 details
HUWE1_HUMANPPARA_HUMANBioGRID29331071 details
HUWE1_HUMANZCHC2_HUMANBioGRID31677785 details
HUWE1_HUMANMAGAB_HUMANBioGRID31980388 33004795 details
HUWE1_HUMANPCF11_HUMANBioGRID31980388 details
HUWE1_HUMANMERL_HUMANBioGRID33058421 details
HUWE1_HUMANCCL1_HUMANHPRD15989956 details