Entity Details

Primary name URP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86UX7
EntryNameURP2_HUMAN
FullNameFermitin family homolog 3
TaxID9606
Evidenceevidence at protein level
Length667
SequenceStatuscomplete
DateCreated2004-01-16
DateModified2021-06-02

Ontological Relatives

GenesFERMT3

GO terms

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GOName
GO:0002102 podosome
GO:0002576 platelet degranulation
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0016020 membrane
GO:0030055 cell-substrate junction
GO:0030335 positive regulation of cell migration
GO:0031093 platelet alpha granule lumen
GO:0033622 integrin activation
GO:0033632 regulation of cell-cell adhesion mediated by integrin
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042995 cell projection
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation

Subcellular Location

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Subcellular Location
Cell projection

Domains

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DomainNameCategoryType
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR037837 Kindlin/fermitin, PH domainDomainDomain
IPR037843 Kindlin/fermitinFamilyFamily
IPR040790 Kindlin-2, N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
612840 OMIMLeukocyte adhesion deficiency 3 (LAD3)A disorder characterized by recurrent bacterial infections without pus formation, leukocytosis and major bleeding disorders. The disease is caused by variants affecting the gene represented in this entry.