Entity Details

Primary name DOT1L_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TEK3
EntryNameDOT1L_HUMAN
FullNameHistone-lysine N-methyltransferase, H3 lysine-79 specific
TaxID9606
Evidenceevidence at protein level
Length1537
SequenceStatuscomplete
DateCreated2002-11-15
DateModified2021-06-02

Ontological Relatives

GenesDOT1L

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006281 DNA repair
GO:0006348 chromatin silencing at telomere
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0010467 gene expression
GO:0018024 histone-lysine N-methyltransferase activity
GO:0031151 histone methyltransferase activity (H3-K79 specific)
GO:0032200 telomere organization
GO:0032991 protein-containing complex
GO:0034729 histone H3-K79 methylation
GO:0042054 histone methyltransferase activity
GO:0043231 intracellular membrane-bounded organelle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:2000677 regulation of transcription regulatory region DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR021169 Histone H3-K79 methyltransferase, metazoaFamilyFamily
IPR025789 Histone-lysine N-methyltransferase DOT1 domainDomainDomain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR030445 Histone H3-K79 methyltransferaseFamilyFamily

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
DOT1L_HUMANAF9_HUMANBioGRID, DIP, IntAct16636056 17332896 20153263 20203130 20431927 20854876 21873227 21896721 23260655 25417107 26496610 details
DOT1L_HUMANAF17_HUMANBioGRID, IntAct19864429 20203130 26344197 26496610 28514442 details
DOT1L_HUMANAF10_HUMANBioGRID, DIP, HPRD, IntAct, MINT15851025 20203130 20431927 21103407 24981860 26496610 details
DOT1L_HUMANH32_HUMANBioGRID, IntAct20203130 21726816 22373577 details
DOT1L_HUMANSTAT1_HUMANBioGRID22002246 details
DOT1L_HUMANH31T_HUMANBioGRID22619169 details
DOT1L_HUMANMYCN_HUMANBioGRID28209620 details
DOT1L_HUMANENL_HUMANBioGRID, IntAct20153263 20203130 20431927 21873227 details
DOT1L_HUMANBAG6_HUMANBioGRID, MINT22373577 details
DOT1L_HUMANCTNB1_HUMANDIP, IntAct20203130 21103407 details
DOT1L_HUMANNPM_HUMANBioGRID, IntAct20431927 26496610 details
DOT1L_HUMANSIR1_HUMANBioGRID19491102 20431927 details
DOT1L_HUMANHNRPM_HUMANBioGRID20431927 details
DOT1L_HUMANH12_HUMANBioGRID20431927 details
DOT1L_HUMANDDX21_HUMANBioGRID20431927 details
DOT1L_HUMANH2B1B_HUMANBioGRID20431927 details
DOT1L_HUMANGRWD1_HUMANBioGRID20431927 details
DOT1L_HUMANHNRPU_HUMANBioGRID20431927 details
DOT1L_HUMANH2A1A_HUMANBioGRID20431927 details
DOT1L_HUMANTHOC4_HUMANBioGRID20431927 details
DOT1L_HUMANYBOX3_HUMANBioGRID20431927 details
DOT1L_HUMANHNRPQ_HUMANBioGRID20431927 details
DOT1L_HUMANGNL3_HUMANBioGRID20431927 details
DOT1L_HUMANH1X_HUMANBioGRID20431927 details
DOT1L_HUMANH11_HUMANBioGRID20431927 details
DOT1L_HUMANKMT2A_HUMANBioGRID20854876 22094252 details
DOT1L_HUMANAFF1_HUMANBioGRID21030982 details
DOT1L_HUMANSCAI_HUMANBioGRID28700933 details
DOT1L_HUMANSMG7_HUMANBioGRID29395067 details
DOT1L_HUMANSPT5H_HUMANBioGRID29395067 details
DOT1L_HUMANANDR_HUMANBioGRID32814769 details