Entity Details

Primary name LEO1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WVC0
EntryNameLEO1_HUMAN
FullNameRNA polymerase-associated protein LEO1
TaxID9606
Evidenceevidence at protein level
Length666
SequenceStatuscomplete
DateCreated2006-07-25
DateModified2021-06-02

Ontological Relatives

GenesLEO1

GO terms

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GOName
GO:0001650 fibrillar center
GO:0001711 endodermal cell fate commitment
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005813 centrosome
GO:0006366 transcription by RNA polymerase II
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006378 mRNA polyadenylation
GO:0010390 histone monoubiquitination
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0016593 Cdc73/Paf1 complex
GO:0019827 stem cell population maintenance
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 histone H2B ubiquitination
GO:0045638 negative regulation of myeloid cell differentiation
GO:1904837 beta-catenin-TCF complex assembly
GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR007149 Leo1-like proteinFamilyFamily

Diseases

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Interactions

24 interactions

InteractorPartnerSourcesPublicationsLink
LEO1_HUMANPAF1_HUMANBioGRID, IntAct, MINT, UniProt15632063 16024656 18469135 19410543 20178742 20305087 21726809 22939629 24981860 25416956 26344197 26496610 32296183 details
LEO1_HUMANTCEA1_HUMANBioGRID, IntAct20178742 details
LEO1_HUMANCSK21_HUMANBioGRID, IntAct22113938 22939629 details
LEO1_HUMANRPB1_HUMANBioGRID, UniProt16024656 20178742 details
LEO1_HUMANBHLH9_HUMANBioGRID, IntAct32296183 details
LEO1_HUMANTCEA3_HUMANBioGRID, IntAct32296183 details
LEO1_HUMANH12_HUMANBioGRID24360965 details
LEO1_HUMANERPG3_HUMANBioGRID31722399 details
LEO1_HUMANERCC6_HUMANBioGRID31722399 details
LEO1_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct16630820 details
LEO1_HUMANCDC73_HUMANBioGRID, DIP, IntAct, MINT, UniProt15632063 15923622 16024656 18469135 19136632 20178742 20305087 21726809 22939629 24981860 26186194 26344197 26496610 28514442 29774127 details
LEO1_HUMANCTR9_HUMANBioGRID, IntAct, MINT, UniProt15632063 16024656 18469135 20178742 20305087 22532828 22939629 24981860 26344197 26496610 27173435 unassigned1312 details
LEO1_HUMANRTF1_HUMANBioGRID, IntAct, UniProt16024656 18469135 20178742 22939629 26344197 details
LEO1_HUMANWDR61_HUMANBioGRID, IntAct, MINT, UniProt16024656 20305087 22451921 24981860 26344197 26496610 details
LEO1_HUMANELOA1_HUMANBioGRID, IntAct26496610 27173435 unassigned1312 details
LEO1_HUMANSETB1_HUMANMINT29774127 details
LEO1_HUMANEHMT2_HUMANMINT29774127 details
LEO1_HUMANECHA_HUMANBioGRID20305087 details
LEO1_HUMANECHB_HUMANBioGRID20305087 details
LEO1_HUMANPP1G_HUMANBioGRID20305087 30344098 details
LEO1_HUMANH31_HUMANBioGRID22451921 details
LEO1_HUMANPTN11_HUMANBioGRID21726809 details
LEO1_HUMANH11_HUMANBioGRID24360965 details
LEO1_HUMANSMG7_HUMANBioGRID29395067 details