Entity Details

Primary name RPGF4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WZA2
EntryNameRPGF4_HUMAN
FullNameRap guanine nucleotide exchange factor 4
TaxID9606
Evidenceevidence at protein level
Length1011
SequenceStatuscomplete
DateCreated2003-06-20
DateModified2021-06-02

Ontological Relatives

GenesRAPGEF4

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0016020 membrane
GO:0017156 calcium-ion regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0019933 cAMP-mediated signaling
GO:0030073 insulin secretion
GO:0030552 cAMP binding
GO:0031267 small GTPase binding
GO:0050796 regulation of insulin secretion
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098693 regulation of synaptic vesicle cycle

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000591 DEP domainDomainDomain
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR019804 Ras guanine-nucleotide exchange factor, conserved siteSiteConserved site
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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