Entity Details

Primary name PTPRU_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92729
EntryNamePTPRU_HUMAN
FullNameReceptor-type tyrosine-protein phosphatase U
TaxID9606
Evidenceevidence at protein level
Length1446
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPTPRU

GO terms

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GOName
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0006470 protein dephosphorylation
GO:0007155 cell adhesion
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0008013 beta-catenin binding
GO:0008285 negative regulation of cell population proliferation
GO:0030154 cell differentiation
GO:0030336 negative regulation of cell migration
GO:0031100 animal organ regeneration
GO:0034109 homotypic cell-cell adhesion
GO:0034394 protein localization to cell surface
GO:0051384 response to glucocorticoid
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR000998 MAM domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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