Entity Details

Primary name SHIP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92835
EntryNameSHIP1_HUMAN
FullNamePhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
TaxID9606
Evidenceevidence at protein level
Length1189
SequenceStatuscomplete
DateCreated2007-09-11
DateModified2021-06-02

Ontological Relatives

GenesINPP5D

GO terms

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GOName
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006796 phosphate-containing compound metabolic process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008340 determination of adult lifespan
GO:0009968 negative regulation of signal transduction
GO:0016064 immunoglobulin mediated immune response
GO:0017124 SH3 domain binding
GO:0019221 cytokine-mediated signaling pathway
GO:0030889 negative regulation of B cell proliferation
GO:0032715 negative regulation of interleukin-6 production
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043647 inositol phosphate metabolic process
GO:0045121 membrane raft
GO:0045579 positive regulation of B cell differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045656 negative regulation of monocyte differentiation
GO:0045659 negative regulation of neutrophil differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045779 negative regulation of bone resorption
GO:0046856 phosphatidylinositol dephosphorylation
GO:0050777 negative regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR000300 Inositol polyphosphate-related phosphataseDomainDomain
IPR000980 SH2 domainDomainDomain
IPR005135 Endonuclease/exonuclease/phosphataseDomainDomain
IPR036691 Endonuclease/exonuclease/phosphatase superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
SHIP1_HUMANSHC1_HUMANBioGRID, HPRD, MINT10194451 10704825 10822173 10900203 11453982 12024011 12149229 15470047 8643691 8723348 8874179 details
SHIP1_HUMANEPOR_HUMANBioGRID, HPRD, IntAct, MINT10660611 15644415 details
SHIP1_HUMANFCG2B_HUMANBioGRID, HPRD, MINT, UniProt10382761 11453982 24642916 9148918 9232445 details
SHIP1_HUMANSH3K1_HUMANBioGRID, MINT15090612 22815893 details
SHIP1_HUMANSLAF1_HUMANBioGRID, MINT10229804 11313386 details
SHIP1_HUMANIL4RA_HUMANBioGRID, HPRD, MINT11714803 details
SHIP1_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
SHIP1_HUMANKR109_HUMANBioGRID, IntAct25416956 details
SHIP1_HUMANKHDR3_HUMANBioGRID, IntAct25416956 32296183 details
SHIP1_HUMANKR107_HUMANBioGRID, IntAct25416956 details
SHIP1_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
SHIP1_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
SHIP1_HUMANNT2NA_HUMANBioGRID, IntAct25416956 details
SHIP1_HUMANLY9_HUMANUniProt26221972 details
SHIP1_HUMANCD244_HUMANUniProt24642916 26221972 details
SHIP1_HUMANSHPS1_HUMANUniProt24642916 details
SHIP1_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
SHIP1_HUMANDOK1_HUMANBioGRID, HPRD10822173 11071635 15151996 details
SHIP1_HUMANLYN_HUMANBioGRID, HPRD12882960 details
SHIP1_HUMANKIT_HUMANBioGRID, HPRD11071635 details
SHIP1_HUMANDAB2_HUMANBioGRID11247302 details
SHIP1_HUMANPTN11_HUMANBioGRID, HPRD11157475 11453982 9110989 details
SHIP1_HUMANPECA1_HUMANBioGRID, HPRD10350061 details
SHIP1_HUMANGRB2_HUMANBioGRID, HPRD10900203 11453982 12149229 22267732 8723348 9108392 details
SHIP1_HUMANCRKL_HUMANBioGRID, HPRD11443118 details
SHIP1_HUMANARAP1_HUMANBioGRID21275903 details
SHIP1_HUMANXIAP_HUMANBioGRID22815893 details
SHIP1_HUMANDAB1_HUMANBioGRID22815893 details
SHIP1_HUMANKR103_HUMANBioGRID25416956 details
SHIP1_HUMANNT2NC_HUMANBioGRID25416956 details
SHIP1_HUMANSHIP1_HUMANBioGRID, HPRD11453982 9422771 details
SHIP1_HUMANKRA13_HUMANBioGRID32296183 details
SHIP1_HUMANCSF1R_HUMANHPRD15735664 details
SHIP1_HUMANMET_HUMANHPRD15735664 details
SHIP1_HUMANHCK_HUMANHPRD, MINT12029088 details
SHIP1_HUMANDOK3_HUMANHPRD, MINT10733577 14993273 17290227 details
SHIP1_HUMANTNR6_HUMANMINT11786908 details
SHIP1_HUMANTNR1A_HUMANMINT11786908 details
SHIP1_HUMANDOK2_HUMANBioGRID, HPRD10822173 details
SHIP1_HUMANCD22_HUMANBioGRID, HPRD10748054 details
SHIP1_HUMANKPCD_HUMANBioGRID12024011 details
SHIP1_HUMANP85A_HUMANBioGRID12506011 9918857 details
SHIP1_HUMANCIP4_HUMANBioGRID19041431 details
SHIP1_HUMANBCR_HUMANBioGRID20304029 details
SHIP1_HUMANCLYBL_HUMANBioGRID20304029 details
SHIP1_HUMANCD2AP_HUMANBioGRID22706086 details
SHIP1_HUMANCBL_HUMANBioGRID22706086 details
SHIP1_HUMANKSYK_HUMANBioGRID22267732 details
SHIP1_HUMANNCK1_HUMANBioGRID22267732 details
SHIP1_HUMANUBS3B_HUMANBioGRID22267732 details
SHIP1_HUMANLRRK1_HUMANBioGRID20697350 details
SHIP1_HUMANFGR_HUMANHPRD10229804 details
SHIP1_HUMANCLM1_HUMANHPRD15184070 details
SHIP1_HUMANFLT3_HUMANHPRD9918857 details
SHIP1_HUMANCSF3R_HUMANHPRD15470047 details
SHIP1_HUMANJAK1_HUMANHPRD10875931 details
SHIP1_HUMANPLCG1_HUMANHPRD15953601 details
SHIP1_HUMANJAK3_HUMANHPRD10875931 details
SHIP1_HUMANGAB1_HUMANHPRD11402314 details
SHIP1_HUMANGAB2_HUMANHPRD11402314 details