Entity Details

Primary name FBXW7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ969H0
EntryNameFBXW7_HUMAN
FullNameF-box/WD repeat-containing protein 7
TaxID9606
Evidenceevidence at protein level
Length707
SequenceStatuscomplete
DateCreated2004-03-01
DateModified2021-06-02

Ontological Relatives

GenesFBXW7

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001570 vasculogenesis
GO:0001944 vasculature development
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006974 cellular response to DNA damage stimulus
GO:0007062 sister chromatid cohesion
GO:0007219 Notch signaling pathway
GO:0010629 negative regulation of gene expression
GO:0010868 negative regulation of triglyceride biosynthetic process
GO:0010883 regulation of lipid storage
GO:0010992 ubiquitin recycling
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0019005 SCF ubiquitin ligase complex
GO:0030324 lung development
GO:0030332 cyclin binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0032880 regulation of protein localization
GO:0032991 protein-containing complex
GO:0034644 cellular response to UV
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687 post-translational protein modification
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045746 negative regulation of Notch signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048511 rhythmic process
GO:0050816 phosphothreonine residue binding
GO:0050821 protein stabilization
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0055088 lipid homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090049 regulation of cell migration involved in sprouting angiogenesis
GO:0097027 ubiquitin-protein transferase activator activity
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1903146 regulation of autophagy of mitochondrion
GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000346 negative regulation of hepatocyte proliferation
GO:2000639 negative regulation of SREBP signaling pathway
GO:2001205 negative regulation of osteoclast development

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR001810 F-box domainDomainDomain
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036047 F-box-like domain superfamilyFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

199 interactions

InteractorPartnerSourcesPublicationsLink
FBXW7_HUMANCCNE1_HUMANBioGRID, HPRD, MINT11533444 11565033 11565034 14536078 14739463 15364936 15980150 16338364 16818231 17298674 17434132 17646408 18559665 19956254 21070969 22388891 24298052 28209614 28850619 31152129 31868589 32051583 details
FBXW7_HUMANCUL1_HUMANBioGRID, HPRD, IntAct, MINT11565034 11585921 14603323 21145461 21205095 22388891 22405651 22524983 23108047 23322298 23453757 25143387 25515538 25720964 26976582 28007894 28514442 28522751 29103612 29408378 29499133 29695787 31285543 32086376 32350066 details
FBXW7_HUMANSHPRH_HUMANBioGRID, HPRD, IntAct16169070 details
FBXW7_HUMANAR6P1_HUMANBioGRID, HPRD, IntAct16169070 details
FBXW7_HUMANMMS22_HUMANBioGRID, HPRD, IntAct16169070 details
FBXW7_HUMANLIGO1_HUMANBioGRID, HPRD, IntAct16169070 details
FBXW7_HUMANWDR97_HUMANBioGRID, IntAct16169070 details
FBXW7_HUMANSUMF2_HUMANBioGRID, HPRD, IntAct16169070 details
FBXW7_HUMANSKP1_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11565034 11585921 12628165 15070733 17434132 19412162 20596027 21205095 21620836 22388891 22524983 22632967 23791182 24811168 25720964 26087183 26474281 26540345 26976582 27247421 28007894 28522751 28614300 29346117 29408378 30728155 31210753 31285543 32086376 32350066 details
FBXW7_HUMANMYC_HUMANBioGRID, HPRD, IntAct, UniProt15103331 15150404 15498494 16023596 17157259 17314511 17646408 17873522 20848231 20970423 22524983 23750012 23791182 25716680 25720964 27795300 28007894 28209614 30606768 31152129 31285543 31569395 32021252 32047362 32345600 32350066 33086033 details
FBXW7_HUMANMYCN_HUMANBioGRID, IntAct19111882 27837025 details
FBXW7_HUMANFBXW7_HUMANBioGRID, IntAct, MINT, UniProt17189384 17298674 21070969 21620836 22608923 23791182 24298052 28007894 28209614 28850619 29346117 30510140 31152129 31285543 details
FBXW7_HUMANCCDC6_HUMANBioGRID, MINT23108047 25885523 details
FBXW7_HUMANSTML1_HUMANBioGRID, UniProt23082202 details
FBXW7_HUMANAKT1_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANAN32B_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANDVL1_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANFANCC_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANF16P1_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANF16P2_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANHEMGN_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANGLT12_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANRASH_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANIBP3_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANMAPK3_HUMANMINT24412244 details
FBXW7_HUMANSIAS_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANCANB2_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANSC61B_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANSHC1_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANSMAD1_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANTGFB1_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANTMOD1_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANXPA_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANZN510_HUMANBioGRID, MINT24412244 details
FBXW7_HUMANANGL4_HUMANBioGRID, MINT25640309 details
FBXW7_HUMANBCAS3_HUMANBioGRID, MINT25640309 details
FBXW7_HUMANBEX1_HUMANBioGRID, MINT25640309 details
FBXW7_HUMANIL24_HUMANBioGRID, MINT25640309 details
FBXW7_HUMANSG3A1_HUMANBioGRID, MINT25640309 details
FBXW7_HUMANTRI25_HUMANBioGRID, MINT25640309 31186535 details
FBXW7_HUMANNOTC1_HUMANBioGRID, DIP, HPRD, MINT11425854 11585921 17526737 17646408 17646409 17909182 20823234 21820430 22388891 23022380 24085301 25344755 26033182 26108681 27229929 27247421 27806347 28459460 30510140 31152129 31285543 32041737 32792479 33086033 details
FBXW7_HUMANFBSP1_HUMANBioGRID, IntAct25720964 28514442 31285543 details
FBXW7_HUMANP53_HUMANBioGRID, IntAct28514442 31346036 31940492 details
FBXW7_HUMANSTYX_HUMANBioGRID, UniProt27880917 28007894 30981757 details
FBXW7_HUMANUNG_HUMANIntAct32814053 details
FBXW7_HUMANPRKN_HUMANBioGRID, HPRD12628165 24793136 details
FBXW7_HUMANMYB_HUMANBioGRID, HPRD18765672 21092141 details
FBXW7_HUMANPRGC1_HUMANBioGRID, HPRD18198341 details
FBXW7_HUMANSRBP1_HUMANBioGRID16054087 19126544 24298052 26759235 27579997 32301540 details
FBXW7_HUMANKLF5_HUMANBioGRID20388706 20484041 24398687 29074464 details
FBXW7_HUMANRACK1_HUMANBioGRID21860413 details
FBXW7_HUMANCCNE2_HUMANBioGRID19084516 details
FBXW7_HUMANEBP2_HUMANBioGRID21220517 details
FBXW7_HUMANGLMN_HUMANBioGRID22405651 details
FBXW7_HUMANUB2R1_HUMANBioGRID19084516 details
FBXW7_HUMANMED13_HUMANBioGRID23322298 25720964 26091241 31285543 details
FBXW7_HUMANMD13L_HUMANBioGRID23322298 25720964 26091241 31285543 details
FBXW7_HUMANKLF2_HUMANBioGRID23507969 details
FBXW7_HUMANMCL1_HUMANBioGRID22608923 28202514 28522751 28619760 32081857 32276600 32352219 details
FBXW7_HUMANGATA3_HUMANBioGRID24820417 details
FBXW7_HUMANMK03_HUMANBioGRID24412244 25753158 details
FBXW7_HUMANGATA2_HUMANBioGRID25670854 details
FBXW7_HUMANJUN_HUMANBioGRID, HPRD14739463 16023596 28036276 29225075 29346117 30044990 31843895 33086033 details
FBXW7_HUMANXRCC4_HUMANBioGRID26774286 30722038 details
FBXW7_HUMANSTAT3_HUMANBioGRID28069035 31843895 details
FBXW7_HUMANPLK1_HUMANBioGRID27773673 details
FBXW7_HUMANSOX9_HUMANBioGRID27566146 32024555 details
FBXW7_HUMANMAGA1_HUMANBioGRID28459460 details
FBXW7_HUMANEXT1_HUMANBioGRID27229929 details
FBXW7_HUMANT22D4_HUMANBioGRID27229929 details
FBXW7_HUMANHNRPK_HUMANBioGRID28423622 details
FBXW7_HUMANBLM_HUMANBioGRID23750012 30044990 details
FBXW7_HUMANDISC1_HUMANBioGRID28727686 details
FBXW7_HUMANNPM_HUMANBioGRID28920929 details
FBXW7_HUMANEZH2_HUMANBioGRID28242758 details
FBXW7_HUMANCEBPD_HUMANBioGRID23575666 details
FBXW7_HUMANPTN11_HUMANBioGRID28287082 details
FBXW7_HUMANKLF10_HUMANBioGRID29198712 details
FBXW7_HUMANUSP9X_HUMANBioGRID29346117 details
FBXW7_HUMANFETUA_HUMANBioGRID29475832 details
FBXW7_HUMANSHOC2_HUMANBioGRID30865892 details
FBXW7_HUMANGFI1_HUMANBioGRID31289136 details
FBXW7_HUMANSTAT2_HUMANBioGRID31843895 details
FBXW7_HUMANSTA5A_HUMANBioGRID31843895 details
FBXW7_HUMANSAS6_HUMANBioGRID32086376 details
FBXW7_HUMANKMT2D_HUMANBioGRID32350066 details
FBXW7_HUMANSIK2_HUMANBioGRID32437091 details
FBXW7_HUMANACD_HUMANBioGRID33086033 details
FBXW7_HUMANSP7_HUMANBioGRID32931083 details
FBXW7_HUMANRFLA_HUMANHPRD16169070 details
FBXW7_HUMANMDM2_HUMANIntAct20708156 details
FBXW7_HUMANHS90B_HUMANIntAct22939624 details
FBXW7_HUMANCDK2_HUMANBioGRID, UniProt23082202 details
FBXW7_HUMANNUDC2_HUMANIntAct25036637 details
FBXW7_HUMANMYCB2_HUMANBioGRID, IntAct25720964 28514442 29346117 31285543 details
FBXW7_HUMANNFKB2_HUMANBioGRID14743216 22388891 22864569 25720964 32350066 details
FBXW7_HUMANPSN1_HUMANBioGRID, HPRD12354302 details
FBXW7_HUMANMTOR_HUMANBioGRID18787170 29346117 31285543 33086033 details
FBXW7_HUMANHIPK2_HUMANBioGRID, HPRD18765672 details
FBXW7_HUMANAURKA_HUMANBioGRID19111882 22513362 28209614 33086033 details
FBXW7_HUMANDCR1C_HUMANBioGRID19423708 details
FBXW7_HUMANHIF1A_HUMANBioGRID21964756 details
FBXW7_HUMANNF2L1_HUMANBioGRID21953459 23623971 details
FBXW7_HUMANPIN1_HUMANBioGRID22608923 25720964 details
FBXW7_HUMANP63_HUMANBioGRID20571051 details
FBXW7_HUMANRBX1_HUMANBioGRID11565034 21205095 22388891 28522751 31285543 32086376 details
FBXW7_HUMANUBP28_HUMANBioGRID17558397 details
FBXW7_HUMANTOP2A_HUMANBioGRID21254166 details
FBXW7_HUMANPSA2_HUMANBioGRID19193609 29346117 details
FBXW7_HUMANREST_HUMANBioGRID18354482 details
FBXW7_HUMANGSK3B_HUMANBioGRID22513362 details
FBXW7_HUMANRICTR_HUMANBioGRID22285861 25897075 details
FBXW7_HUMANJAG1_HUMANBioGRID21820430 details
FBXW7_HUMANBTG1_HUMANBioGRID22975506 details
FBXW7_HUMANAURKB_HUMANBioGRID23095493 31285543 details
FBXW7_HUMANMED12_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANMED1_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANMED14_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANMED23_HUMANBioGRID23322298 details
FBXW7_HUMANMED16_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANMED15_HUMANBioGRID23322298 details
FBXW7_HUMANMED4_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANMED8_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANMED24_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANMED20_HUMANBioGRID23322298 details
FBXW7_HUMANMED22_HUMANBioGRID23322298 details
FBXW7_HUMANMED27_HUMANBioGRID23322298 details
FBXW7_HUMANMED10_HUMANBioGRID23322298 details
FBXW7_HUMANMED9_HUMANBioGRID23322298 details
FBXW7_HUMANMED17_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANMED11_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANMED19_HUMANBioGRID23322298 details
FBXW7_HUMANMED21_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANMED28_HUMANBioGRID23322298 details
FBXW7_HUMANMED29_HUMANBioGRID23322298 details
FBXW7_HUMANMED30_HUMANBioGRID23322298 details
FBXW7_HUMANMED31_HUMANBioGRID23322298 details
FBXW7_HUMANMED6_HUMANBioGRID23322298 25720964 details
FBXW7_HUMANCCNC_HUMANBioGRID23322298 details
FBXW7_HUMANHS90A_HUMANBioGRID22939624 details
FBXW7_HUMANPTEN_HUMANBioGRID23514585 details
FBXW7_HUMANNCOA3_HUMANBioGRID23514585 details
FBXW7_HUMANCSF3R_HUMANBioGRID23820376 details
FBXW7_HUMANU2QL1_HUMANBioGRID24000165 details
FBXW7_HUMANM4K1_HUMANBioGRID24362026 details
FBXW7_HUMANEYA1_HUMANBioGRID24752894 27795300 details
FBXW7_HUMANYAP1_HUMANBioGRID24884509 29891922 details
FBXW7_HUMANDAB2P_HUMANBioGRID24912918 details
FBXW7_HUMANUBP36_HUMANBioGRID25775507 details
FBXW7_HUMANSYUA_HUMANBioGRID26033182 details
FBXW7_HUMANCRY2_HUMANBioGRID25855785 details
FBXW7_HUMANCUL7_HUMANBioGRID12904573 details
FBXW7_HUMANNF2L3_HUMANBioGRID26306035 details
FBXW7_HUMANFA83D_HUMANBioGRID24344117 details
FBXW7_HUMANRND3_HUMANBioGRID26108681 details
FBXW7_HUMANHSF1_HUMANBioGRID25720964 31244938 31409638 details
FBXW7_HUMANMAGC2_HUMANBioGRID26540345 details
FBXW7_HUMANENOA_HUMANBioGRID26097998 details
FBXW7_HUMANBRAF_HUMANBioGRID26898828 details
FBXW7_HUMANSOX10_HUMANBioGRID26461473 details
FBXW7_HUMANDPTOR_HUMANBioGRID22017876 details
FBXW7_HUMANFOXM1_HUMANBioGRID26912724 details
FBXW7_HUMANFAP20_HUMANBioGRID27232758 30789902 details
FBXW7_HUMANCDX2_HUMANBioGRID27470268 details
FBXW7_HUMANCTNB1_HUMANBioGRID27485116 details
FBXW7_HUMANPA2G4_HUMANBioGRID28209614 details
FBXW7_HUMANEGLN2_HUMANBioGRID28036276 details
FBXW7_HUMANGDIR1_HUMANBioGRID28772241 details
FBXW7_HUMANPLK2_HUMANBioGRID27423313 details
FBXW7_HUMANNONO_HUMANBioGRID29150959 details
FBXW7_HUMANGCR_HUMANBioGRID23228967 details
FBXW7_HUMANNFKB1_HUMANBioGRID26269414 details
FBXW7_HUMANTF65_HUMANBioGRID26269414 details
FBXW7_HUMANDDX58_HUMANBioGRID28287082 details
FBXW7_HUMANDNLI4_HUMANBioGRID26774286 details
FBXW7_HUMANNHEJ1_HUMANBioGRID26774286 details
FBXW7_HUMANUBE2N_HUMANBioGRID26774286 details
FBXW7_HUMANSNAI1_HUMANBioGRID30094882 details
FBXW7_HUMANPLAK_HUMANBioGRID29408378 details
FBXW7_HUMANSMCA4_HUMANBioGRID30177679 details
FBXW7_HUMANXBP1_HUMANBioGRID30783083 details
FBXW7_HUMANZEB2_HUMANBioGRID30783098 details
FBXW7_HUMANUT14A_HUMANBioGRID30343112 details
FBXW7_HUMANIRF1_HUMANBioGRID30854564 details
FBXW7_HUMANKDM1A_HUMANBioGRID31152129 details
FBXW7_HUMANSQSTM_HUMANBioGRID31152129 details
FBXW7_HUMANSNX5_HUMANBioGRID31281471 details
FBXW7_HUMANPO5F1_HUMANBioGRID31534970 details
FBXW7_HUMANTTP_HUMANBioGRID31679460 details
FBXW7_HUMANRAGE_HUMANBioGRID32124957 details
FBXW7_HUMANIKBA_HUMANBioGRID31945730 details
FBXW7_HUMANASH2L_HUMANBioGRID32350066 details
FBXW7_HUMANDPY30_HUMANBioGRID32350066 details
FBXW7_HUMANNCOA6_HUMANBioGRID32350066 details
FBXW7_HUMANKDM6A_HUMANBioGRID32350066 details
FBXW7_HUMANWDR5_HUMANBioGRID32350066 details
FBXW7_HUMANNOTC4_HUMANHPRD11585921 details
FBXW7_HUMANHEY1_HUMANHPRD11585921 details