Entity Details

Primary name OPTN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96CV9
EntryNameOPTN_HUMAN
FullNameOptineurin
TaxID9606
Evidenceevidence at protein level
Length577
SequenceStatuscomplete
DateCreated2005-03-29
DateModified2021-06-02

Ontological Relatives

GenesOPTN

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000139 Golgi membrane
GO:0001920 negative regulation of receptor recycling
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005776 autophagosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0006914 autophagy
GO:0007030 Golgi organization
GO:0007165 signal transduction
GO:0008022 protein C-terminus binding
GO:0008219 cell death
GO:0010508 positive regulation of autophagy
GO:0016032 viral process
GO:0030674 protein-macromolecule adaptor activity
GO:0031267 small GTPase binding
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0034067 protein localization to Golgi apparatus
GO:0034620 cellular response to unfolded protein
GO:0042802 identical protein binding
GO:0043001 Golgi to plasma membrane protein transport
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050829 defense response to Gram-negative bacterium
GO:0055038 recycling endosome membrane
GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0090161 Golgi ribbon formation
GO:1904417 positive regulation of xenophagy

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus
Recycling endosome

Domains

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DomainNameCategoryType
IPR021063 NF-kappa-B essential modulator NEMO, N-terminalDomainDomain
IPR032419 NF-kappa-B essential modulator NEMO, CC2-LZ domainDomainDomain
IPR032939 OptineurinFamilyFamily
IPR034735 NEMO, Zinc fingerDomainDomain

Diseases

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Interactions

262 interactions

InteractorPartnerSourcesPublicationsLink
OPTN_HUMANHD_HUMANBioGRID, HPRD, IntAct, MINT11137014 17500595 23275563 29394115 30886048 32814053 9700202 details
OPTN_HUMANRNF11_HUMANBioGRID, HPRD, MINT15231748 details
OPTN_HUMANWASC3_HUMANBioGRID, HPRD, IntAct, MINT16189514 21516116 25416956 25910212 26871637 31515488 32296183 details
OPTN_HUMANTBC17_HUMANBioGRID, HPRD, IntAct, UniProt16189514 22854040 31723608 details
OPTN_HUMANTBK1_HUMANBioGRID, IntAct, MINT18307994 20174559 21903422 23414517 25803835 25923723 26365381 27035970 27086836 27538435 27620379 29395067 30327196 31723608 32556086 details
OPTN_HUMANZMAT2_HUMANIntAct20195357 32814053 details
OPTN_HUMANQCR8_HUMANBioGRID, IntAct20195357 details
OPTN_HUMANSLF2_HUMANBioGRID, IntAct20195357 details
OPTN_HUMANALEX_HUMANBioGRID, IntAct20195357 details
OPTN_HUMANF1892_HUMANBioGRID, MINT21516116 details
OPTN_HUMANLNX2_HUMANBioGRID, IntAct, MINT21516116 29892012 31515488 details
OPTN_HUMANCDC23_HUMANBioGRID, IntAct, MINT21516116 25416956 25910212 details
OPTN_HUMANTNIP1_HUMANBioGRID, IntAct, MINT21516116 21988832 23414517 25416956 25910212 26871637 28514442 30561431 31515488 32296183 details
OPTN_HUMANPIAS4_HUMANBioGRID, IntAct21988832 details
OPTN_HUMANDYST_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANNEBU_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANSLMAP_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANVWF_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANSNX6_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANDYSF_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANTITIN_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANAKAP6_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANKAL1L_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANCLH1_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANCMYA5_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANDZIP1_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANFRIH_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANMYH3_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANOPTN_HUMANBioGRID, IntAct20161783 23414517 24983867 25416956 25910212 26871637 29394115 30327196 31723608 32296183 details
OPTN_HUMANUBB_HUMANBioGRID, IntAct23414517 31723608 details
OPTN_HUMANUBC_HUMANBioGRID, IntAct17702576 18212736 19285159 21408173 21617041 21862579 23178947 23414517 25969509 26365381 26451915 27035970 27552911 28190767 28319114 29133525 29394115 31155706 32556086 details
OPTN_HUMANTERA_HUMANBioGRID, IntAct23414517 31723608 details
OPTN_HUMANZN181_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANZN302_HUMANBioGRID, IntAct23414517 32814053 details
OPTN_HUMANZN426_HUMANBioGRID, IntAct23414517 32296183 details
OPTN_HUMANZN711_HUMANBioGRID, IntAct23414517 details
OPTN_HUMANEM55_HUMANBioGRID, IntAct21903422 details
OPTN_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
OPTN_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
OPTN_HUMANRAB8A_HUMANBioGRID, HPRD, UniProt11137014 20085643 20161783 20388642 20634958 22854040 23357852 details
OPTN_HUMANHACE1_HUMANBioGRID, IntAct25026213 details
OPTN_HUMANMLP3B_HUMANBioGRID, IntAct21617041 23805866 25026213 30679426 32296703 details
OPTN_HUMANSQSTM_HUMANBioGRID, IntAct25026213 31723608 details
OPTN_HUMANRAB10_HUMANBioGRID, IntAct25416956 30945962 details
OPTN_HUMANDAZP2_HUMANBioGRID, IntAct25416956 32296183 details
OPTN_HUMANZN329_HUMANBioGRID, IntAct25416956 details
OPTN_HUMANTBC15_HUMANBioGRID, IntAct25416956 31723608 32296183 32814053 details
OPTN_HUMANZN398_HUMANBioGRID, IntAct25416956 details
OPTN_HUMANZN670_HUMANBioGRID, IntAct25416956 32296183 details
OPTN_HUMANRBM12_HUMANBioGRID, IntAct25910212 32296183 details
OPTN_HUMANPO6F2_HUMANBioGRID, IntAct32296183 details
OPTN_HUMANUBP2_HUMANBioGRID, IntAct32296183 details
OPTN_HUMANAIMP1_HUMANBioGRID, IntAct28514442 32296183 details
OPTN_HUMANARRD3_HUMANBioGRID, IntAct32296183 details
OPTN_HUMANZNF17_HUMANBioGRID, IntAct32296183 details
OPTN_HUMANRN216_HUMANBioGRID, IntAct32296183 details
OPTN_HUMANSDCB1_HUMANBioGRID, IntAct32296183 details
OPTN_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
OPTN_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
OPTN_HUMANCCD13_HUMANBioGRID, IntAct32296183 details
OPTN_HUMANLITAF_HUMANBioGRID, IntAct25910212 32814053 details
OPTN_HUMANAPBB2_HUMANIntAct32814053 details
OPTN_HUMANDYN2_HUMANIntAct32814053 details
OPTN_HUMANTOR1A_HUMANIntAct32814053 details
OPTN_HUMANNDUV1_HUMANIntAct32814053 details
OPTN_HUMANWFS1_HUMANIntAct32814053 details
OPTN_HUMANSMRD1_HUMANIntAct32814053 details
OPTN_HUMANSIA8A_HUMANIntAct32814053 details
OPTN_HUMANS10A1_HUMANIntAct32814053 details
OPTN_HUMANRNF5_HUMANIntAct32814053 details
OPTN_HUMANRARA_HUMANIntAct32814053 details
OPTN_HUMANRAPSN_HUMANIntAct32814053 details
OPTN_HUMANGDS1_HUMANIntAct32814053 details
OPTN_HUMANPRS7_HUMANIntAct32814053 details
OPTN_HUMANPROS_HUMANIntAct32814053 details
OPTN_HUMANPLTP_HUMANIntAct32814053 details
OPTN_HUMANPDE4D_HUMANIntAct32814053 details
OPTN_HUMANP2RY4_HUMANIntAct32814053 details
OPTN_HUMANMECP2_HUMANIntAct32814053 details
OPTN_HUMANSMAD1_HUMANIntAct32814053 details
OPTN_HUMANLASP1_HUMANIntAct32814053 details
OPTN_HUMANRED_HUMANIntAct32814053 details
OPTN_HUMANIRF8_HUMANIntAct32814053 details
OPTN_HUMAN5HT1E_HUMANIntAct32814053 details
OPTN_HUMANDPB1_HUMANIntAct32814053 details
OPTN_HUMANTZAP_HUMANIntAct32814053 details
OPTN_HUMANGBRG1_HUMANIntAct32814053 details
OPTN_HUMANCRYM_HUMANIntAct32814053 details
OPTN_HUMANCBPN_HUMANIntAct32814053 details
OPTN_HUMANCOF1_HUMANIntAct32814053 details
OPTN_HUMANCENPA_HUMANIntAct32814053 details
OPTN_HUMANENTP2_HUMANIntAct32814053 details
OPTN_HUMANCAN1_HUMANIntAct32814053 details
OPTN_HUMANBIRC5_HUMANIntAct32814053 details
OPTN_HUMANANXA5_HUMANIntAct32814053 details
OPTN_HUMANPPAC_HUMANIntAct32814053 details
OPTN_HUMANSYTC_HUMANIntAct32814053 details
OPTN_HUMANQKI_HUMANIntAct32814053 details
OPTN_HUMANLPXN_HUMANIntAct32814053 details
OPTN_HUMANZMYM4_HUMANIntAct32814053 details
OPTN_HUMANPAPS2_HUMANIntAct32814053 details
OPTN_HUMANSUCB1_HUMANIntAct32814053 details
OPTN_HUMANASML_HUMANIntAct32814053 details
OPTN_HUMANMKNK1_HUMANIntAct32814053 details
OPTN_HUMANAP3B1_HUMANIntAct32814053 details
OPTN_HUMANNCOA3_HUMANIntAct32814053 details
OPTN_HUMANGPAN1_HUMANIntAct32814053 details
OPTN_HUMANRN112_HUMANIntAct32814053 details
OPTN_HUMANZKSC1_HUMANIntAct32814053 details
OPTN_HUMANZBT14_HUMANIntAct32814053 details
OPTN_HUMANVINC_HUMANIntAct32814053 details
OPTN_HUMANUBE2A_HUMANIntAct32814053 details
OPTN_HUMANTHOP1_HUMANBioGRID, IntAct31723608 32814053 details
OPTN_HUMANTERF1_HUMANIntAct32814053 details
OPTN_HUMANTEAD1_HUMANIntAct32814053 details
OPTN_HUMANPP1RB_HUMANIntAct32814053 details
OPTN_HUMANSTIM1_HUMANIntAct32814053 details
OPTN_HUMANBRWD1_HUMANIntAct32814053 details
OPTN_HUMANASB4_HUMANIntAct32814053 details
OPTN_HUMANNIP7_HUMANIntAct32814053 details
OPTN_HUMANATLA1_HUMANIntAct32814053 details
OPTN_HUMANVILL_HUMANIntAct32814053 details
OPTN_HUMANS39A1_HUMANIntAct32814053 details
OPTN_HUMANDKK4_HUMANIntAct32814053 details
OPTN_HUMANBSCL2_HUMANIntAct32814053 details
OPTN_HUMANMYEOV_HUMANIntAct32814053 details
OPTN_HUMANSMUG1_HUMANIntAct32814053 details
OPTN_HUMANMTFP1_HUMANIntAct32814053 details
OPTN_HUMANZN281_HUMANIntAct32814053 details
OPTN_HUMANWDFY3_HUMANIntAct32814053 details
OPTN_HUMANSNW1_HUMANIntAct32814053 details
OPTN_HUMANMGT4B_HUMANIntAct32814053 details
OPTN_HUMANCP250_HUMANIntAct32814053 details
OPTN_HUMANBT3A2_HUMANIntAct32814053 details
OPTN_HUMANP3H3_HUMANIntAct32814053 details
OPTN_HUMANPDZ1I_HUMANIntAct32814053 details
OPTN_HUMANRASF2_HUMANIntAct32814053 details
OPTN_HUMANFXR2_HUMANIntAct32814053 details
OPTN_HUMANHAND2_HUMANIntAct32814053 details
OPTN_HUMANPEX16_HUMANIntAct32814053 details
OPTN_HUMANZN419_HUMANIntAct32814053 details
OPTN_HUMANRN111_HUMANIntAct32814053 details
OPTN_HUMANZY11B_HUMANIntAct32814053 details
OPTN_HUMANTUT7_HUMANIntAct32814053 details
OPTN_HUMANACSS3_HUMANIntAct32814053 details
OPTN_HUMANTHADA_HUMANIntAct32814053 details
OPTN_HUMANAB17C_HUMANIntAct32814053 details
OPTN_HUMANWDFY4_HUMANIntAct32814053 details
OPTN_HUMANBEGIN_HUMANIntAct32814053 details
OPTN_HUMANNMRL1_HUMANIntAct32814053 details
OPTN_HUMANDUS3L_HUMANIntAct32814053 details
OPTN_HUMANSPHK2_HUMANIntAct32814053 details
OPTN_HUMANBTNL2_HUMANIntAct32814053 details
OPTN_HUMANCEP72_HUMANIntAct32814053 details
OPTN_HUMANZN446_HUMANIntAct32814053 details
OPTN_HUMANZN444_HUMANIntAct32814053 details
OPTN_HUMANAGGF1_HUMANIntAct32814053 details
OPTN_HUMANRPP25_HUMANIntAct32814053 details
OPTN_HUMANESRP1_HUMANIntAct32814053 details
OPTN_HUMANASCL4_HUMANIntAct32814053 details
OPTN_HUMANH32_HUMANIntAct32814053 details
OPTN_HUMANMYCT_HUMANIntAct32814053 details
OPTN_HUMANLDH6B_HUMANIntAct32814053 details
OPTN_HUMANDPP9_HUMANIntAct32814053 details
OPTN_HUMANZHX1R_HUMANIntAct32814053 details
OPTN_HUMANHUMMR_HUMANIntAct32814053 details
OPTN_HUMANGLYR1_HUMANIntAct32814053 details
OPTN_HUMANZGPAT_HUMANIntAct32814053 details
OPTN_HUMANHDA10_HUMANIntAct32814053 details
OPTN_HUMANKRA92_HUMANIntAct32814053 details
OPTN_HUMANJADE1_HUMANIntAct32814053 details
OPTN_HUMANSPAS1_HUMANIntAct32814053 details
OPTN_HUMANSYNE4_HUMANIntAct32814053 details
OPTN_HUMANRETR3_HUMANIntAct32814053 details
OPTN_HUMANCH048_HUMANIntAct32814053 details
OPTN_HUMANTHAP6_HUMANIntAct32814053 details
OPTN_HUMANCNIH3_HUMANIntAct32814053 details
OPTN_HUMANZN597_HUMANIntAct32814053 details
OPTN_HUMANCO032_HUMANIntAct32814053 details
OPTN_HUMANNUDC2_HUMANIntAct32814053 details
OPTN_HUMANSGSM1_HUMANIntAct32814053 details
OPTN_HUMANZN488_HUMANIntAct32814053 details
OPTN_HUMANOXLA_HUMANIntAct32814053 details
OPTN_HUMANPALM2_HUMANIntAct32814053 details
OPTN_HUMANYI025_HUMANIntAct32814053 details
OPTN_HUMANIRGM_HUMANIntAct32814053 details
OPTN_HUMANANR45_HUMANIntAct32814053 details
OPTN_HUMANARL16_HUMANIntAct32814053 details
OPTN_HUMANCQ067_HUMANIntAct32814053 details
OPTN_HUMANMMAB_HUMANIntAct32814053 details
OPTN_HUMANPAXX_HUMANIntAct32814053 details
OPTN_HUMANK0825_HUMANIntAct32814053 details
OPTN_HUMANOD3L2_HUMANIntAct32814053 details
OPTN_HUMANOFCC1_HUMANIntAct32814053 details
OPTN_HUMANGDAP1_HUMANIntAct32814053 details
OPTN_HUMANCYLD_HUMANBioGRID21408173 25923723 details
OPTN_HUMANRIPK1_HUMANBioGRID17702576 21408173 22675546 27552911 details
OPTN_HUMANCDN1A_HUMANBioGRID19609363 details
OPTN_HUMANCALM1_HUMANBioGRID15840729 details
OPTN_HUMANCALM2_HUMANBioGRID15840729 details
OPTN_HUMANCALM3_HUMANBioGRID15840729 details
OPTN_HUMANGBRL1_HUMANBioGRID21617041 31723608 details
OPTN_HUMANMLP3A_HUMANBioGRID21617041 25026213 details
OPTN_HUMANMYO6_HUMANBioGRID15837803 19805065 20161783 26451915 26971995 details
OPTN_HUMANGRM1_HUMANBioGRID16091361 details
OPTN_HUMANRAB14_HUMANBioGRID19702578 details
OPTN_HUMANRB11A_HUMANBioGRID16905101 17626244 24056041 details
OPTN_HUMANEPS15_HUMANBioGRID17626244 31723608 details
OPTN_HUMANRAB12_HUMANBioGRID23357852 details
OPTN_HUMANGNAS3_HUMANBioGRID20195357 details
OPTN_HUMANGNAS2_HUMANBioGRID20195357 details
OPTN_HUMANGNAS1_HUMANBioGRID20195357 details
OPTN_HUMANRAB25_HUMANBioGRID24056041 details
OPTN_HUMANRB11B_HUMANBioGRID, HPRD11495908 24056041 details
OPTN_HUMANGBRAP_HUMANBioGRID21617041 31723608 details
OPTN_HUMANGBRL2_HUMANBioGRID21617041 31723608 details
OPTN_HUMANMLP3C_HUMANBioGRID26451915 details
OPTN_HUMANATG5_HUMANBioGRID27879200 29133525 details
OPTN_HUMANIRAK1_HUMANBioGRID28882891 details
OPTN_HUMANA16L1_HUMANBioGRID29133525 details
OPTN_HUMANWIPI2_HUMANBioGRID29133525 31723608 details
OPTN_HUMANRFFL_HUMANBioGRID30659120 details
OPTN_HUMANFLII_HUMANHPRD10366446 details
OPTN_HUMANMACF1_HUMANIntAct20195357 details
OPTN_HUMANGRP75_HUMANIntAct20195357 details
OPTN_HUMANIF4G2_HUMANIntAct20195357 details
OPTN_HUMANCENPB_HUMANIntAct20195357 details
OPTN_HUMANNDUF2_HUMANIntAct20195357 details
OPTN_HUMANRTN3_HUMANIntAct20195357 details
OPTN_HUMANSYGP1_HUMANIntAct20195357 details
OPTN_HUMANEBP2_HUMANIntAct20195357 details
OPTN_HUMANABRX2_HUMANIntAct20195357 details
OPTN_HUMANPPARG_HUMANIntAct20195357 details
OPTN_HUMANRL37A_HUMANIntAct20195357 details
OPTN_HUMANNRL_HUMANBioGRID, IntAct23956131 details
OPTN_HUMANWDR41_HUMANMINT27103069 details
OPTN_HUMANTAXB1_HUMANBioGRID19609363 details
OPTN_HUMANTFR1_HUMANBioGRID20085643 20161783 20634958 23357852 details
OPTN_HUMANTRAF3_HUMANBioGRID20174559 details
OPTN_HUMANTRADD_HUMANBioGRID17702576 details
OPTN_HUMANSODC_HUMANBioGRID23178947 32014991 details
OPTN_HUMANTNR1A_HUMANBioGRID22675546 details
OPTN_HUMANTNFA_HUMANBioGRID22675546 27307491 details
OPTN_HUMANPRKN_HUMANBioGRID25294927 31723608 details
OPTN_HUMANMYH6_HUMANBioGRID25859013 details
OPTN_HUMANNEMO_HUMANBioGRID27552911 details
OPTN_HUMANCASP8_HUMANBioGRID27552911 details
OPTN_HUMANCH60_HUMANBioGRID30945962 details
OPTN_HUMANA4_HUMANBioGRID25126727 details
OPTN_HUMANBIRC6_HUMANBioGRID31213539 details
OPTN_HUMANLEG3_HUMANBioGRID30404831 details
OPTN_HUMANIKKB_HUMANBioGRID29474632 details
OPTN_HUMANCACO2_HUMANBioGRID31723608 details
OPTN_HUMANMFF_HUMANBioGRID31723608 details
OPTN_HUMANRBCC1_HUMANBioGRID31723608 details
OPTN_HUMANULK1_HUMANBioGRID31723608 details
OPTN_HUMANBAKOR_HUMANBioGRID31723608 details
OPTN_HUMANTOM40_HUMANBioGRID31723608 details
OPTN_HUMANDCAF4_HUMANBioGRID32014991 details
OPTN_HUMANATG9A_HUMANBioGRID32556086 details
OPTN_HUMANTF3A_HUMANHPRD10756201 details
OPTN_HUMANFOS_HUMANHPRD15867431 details