Entity Details

Primary name GDF8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14793
EntryNameGDF8_HUMAN
FullNameGrowth/differentiation factor 8
TaxID9606
Evidenceevidence at protein level
Length375
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesMSTN

GO terms

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GOName
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007517 muscle organ development
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0009408 response to heat
GO:0009629 response to gravity
GO:0010592 positive regulation of lamellipodium assembly
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014732 skeletal muscle atrophy
GO:0014741 negative regulation of muscle hypertrophy
GO:0014839 myoblast migration involved in skeletal muscle regeneration
GO:0014850 response to muscle activity
GO:0022602 ovulation cycle process
GO:0033574 response to testosterone
GO:0033673 negative regulation of kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043627 response to estrogen
GO:0045471 response to ethanol
GO:0045662 negative regulation of myoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046716 muscle cell cellular homeostasis
GO:0048632 negative regulation of skeletal muscle tissue growth
GO:0051602 response to electrical stimulus
GO:0051898 negative regulation of protein kinase B signaling
GO:0060395 SMAD protein signal transduction
GO:0071549 cellular response to dexamethasone stimulus
GO:1902723 negative regulation of skeletal muscle satellite cell proliferation
GO:1902725 negative regulation of satellite cell differentiation
GO:2000818 negative regulation of myoblast proliferation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR015616 Growth/differentiation factor 8FamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05915 MYO-029Drugbankbiotech