Entity Details

Primary name NLRP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96P20
EntryNameNLRP3_HUMAN
FullNameNACHT, LRR and PYD domains-containing protein 3
TaxID9606
Evidenceevidence at protein level
Length1036
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesNLRP3

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002674 negative regulation of acute inflammatory response
GO:0002830 positive regulation of type 2 immune response
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0008134 transcription factor binding
GO:0009595 detection of biotic stimulus
GO:0014070 response to organic cyclic compound
GO:0016579 protein deubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032753 positive regulation of interleukin-4 production
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042802 identical protein binding
GO:0042834 peptidoglycan binding
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071222 cellular response to lipopolysaccharide
GO:0072559 NLRP3 inflammasome complex
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:2000553 positive regulation of T-helper 2 cell cytokine production

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Golgi apparatus membrane
Inflammasome
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR004020 DAPIN domainDomainDomain
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029495 NACHT-associated domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
NLRP3_HUMANASC_HUMANBioGRID, DIP, HPRD, IntAct, UniProt11786556 15020601 19158675 24630722 28229991 30182366 30653357 32003754 32435622 details
NLRP3_HUMANNLRP3_HUMANIntAct23582325 24630722 details
NLRP3_HUMANKSYK_HUMANIntAct25605870 details
NLRP3_HUMANE2AK2_HUMANDIP22801494 details
NLRP3_HUMANNEK7_HUMANBioGRID, DIP, IntAct26814970 31189953 31762063 31866999 32814053 details
NLRP3_HUMANCALR_HUMANIntAct32814053 details
NLRP3_HUMANODO2_HUMANIntAct32814053 details
NLRP3_HUMANFAF1_HUMANBioGRID17046979 details
NLRP3_HUMANFBXL2_HUMANBioGRID26037928 details
NLRP3_HUMANTRI31_HUMANBioGRID27929086 32323100 32716108 details
NLRP3_HUMANCUL1_HUMANBioGRID30653357 details
NLRP3_HUMANPGM1_HUMANBioGRID30653357 details
NLRP3_HUMANAT1B3_HUMANBioGRID30653357 details
NLRP3_HUMANVDR_HUMANBioGRID31866999 details
NLRP3_HUMANSTABP_HUMANBioGRID32003754 details
NLRP3_HUMANMLP3A_HUMANInnateDB22286270 details
NLRP3_HUMANMAVS_HUMANDIP, IntAct23582325 26494172 details
NLRP3_HUMANCARD8_HUMANHPRD, IntAct15030775 28137891 details
NLRP3_HUMANNLRC4_HUMANBioGRID15107016 details
NLRP3_HUMANSGT1_HUMANBioGRID17435760 details
NLRP3_HUMANHS90A_HUMANBioGRID17435760 details
NLRP3_HUMANDHX33_HUMANBioGRID25172487 details
NLRP3_HUMANULK1_HUMANBioGRID26347139 details
NLRP3_HUMANMEFV_HUMANBioGRID26347139 details
NLRP3_HUMANCHIP_HUMANBioGRID25594175 details
NLRP3_HUMANMARH7_HUMANBioGRID25594175 details
NLRP3_HUMANUBR5_HUMANBioGRID25594175 details
NLRP3_HUMANHDAC6_HUMANBioGRID26471297 details
NLRP3_HUMANUBP50_HUMANBioGRID28094437 details
NLRP3_HUMANARI2_HUMANBioGRID29021376 details
NLRP3_HUMANTXNIP_HUMANBioGRID28326454 30833078 details
NLRP3_HUMANRBX1_HUMANBioGRID30653357 details
NLRP3_HUMANABRX2_HUMANBioGRID30787184 details
NLRP3_HUMANBRCC3_HUMANBioGRID30787184 31866999 details
NLRP3_HUMANCASP8_HUMANBioGRID30182366 details
NLRP3_HUMANP2RY2_HUMANBioGRID31553908 details
NLRP3_HUMANSRC_HUMANBioGRID31553908 details
NLRP3_HUMANMARK4_HUMANBioGRID31167564 details
NLRP3_HUMANSQSTM_HUMANBioGRID32003754 details
NLRP3_HUMANCBLB_HUMANBioGRID31999304 details
NLRP3_HUMANRN125_HUMANBioGRID31999304 details
NLRP3_HUMANIL1B_HUMANBioGRID32597834 details