Entity Details

Primary name S1PR3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99500
EntryNameS1PR3_HUMAN
FullNameSphingosine 1-phosphate receptor 3
TaxID9606
Evidenceevidence at protein level
Length378
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesS1PR3

GO terms

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GOName
GO:0004930 G protein-coupled receptor activity
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007219 Notch signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0008289 lipid binding
GO:0009653 anatomical structure morphogenesis
GO:0019222 regulation of metabolic process
GO:0032651 regulation of interleukin-1 beta production
GO:0038036 sphingosine-1-phosphate receptor activity
GO:1903141 negative regulation of establishment of endothelial barrier

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR004061 Sphingosine 1-phosphate receptorFamilyFamily
IPR004062 EDG-3 sphingosine 1-phosphate receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB08868 FingolimodDrugbanksmall molecule