Entity Details

Primary name PINK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BXM7
EntryNamePINK1_HUMAN
FullNameSerine/threonine-protein kinase PINK1, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length581
SequenceStatuscomplete
DateCreated2004-06-07
DateModified2021-06-02

Ontological Relatives

GenesPINK1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000422 autophagy of mitochondrion
GO:0000785 chromatin
GO:0001934 positive regulation of protein phosphorylation
GO:0002020 protease binding
GO:0002082 regulation of oxidative phosphorylation
GO:0002931 response to ischemia
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006468 protein phosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006979 response to oxidative stress
GO:0007005 mitochondrion organization
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0010629 negative regulation of gene expression
GO:0010821 regulation of mitochondrion organization
GO:0010857 calcium-dependent protein kinase activity
GO:0010952 positive regulation of peptidase activity
GO:0016020 membrane
GO:0016236 macroautophagy
GO:0016239 positive regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016504 peptidase activator activity
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0022904 respiratory electron transport chain
GO:0030424 axon
GO:0030426 growth cone
GO:0031307 integral component of mitochondrial outer membrane
GO:0031396 regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032148 activation of protein kinase B activity
GO:0032226 positive regulation of synaptic transmission, dopaminergic
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033603 positive regulation of dopamine secretion
GO:0034599 cellular response to oxidative stress
GO:0035307 positive regulation of protein dephosphorylation
GO:0035556 intracellular signal transduction
GO:0036289 peptidyl-serine autophosphorylation
GO:0038203 TORC2 signaling
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein-containing complex assembly
GO:0043422 protein kinase B binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045727 positive regulation of translation
GO:0046329 negative regulation of JNK cascade
GO:0048471 perinuclear region of cytoplasm
GO:0050821 protein stabilization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051881 regulation of mitochondrial membrane potential
GO:0051897 positive regulation of protein kinase B signaling
GO:0055131 C3HC4-type RING finger domain binding
GO:0061136 regulation of proteasomal protein catabolic process
GO:0071456 cellular response to hypoxia
GO:0072655 establishment of protein localization to mitochondrion
GO:0072656 maintenance of protein location in mitochondrion
GO:0090141 positive regulation of mitochondrial fission
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090258 negative regulation of mitochondrial fission
GO:0097237 cellular response to toxic substance
GO:0097413 Lewy body
GO:0097449 astrocyte projection
GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization
GO:0099074 mitochondrion to lysosome transport
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900407 regulation of cellular response to oxidative stress
GO:1901727 positive regulation of histone deacetylase activity
GO:1902803 regulation of synaptic vesicle transport
GO:1902902 negative regulation of autophagosome assembly
GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903146 regulation of autophagy of mitochondrion
GO:1903147 negative regulation of autophagy of mitochondrion
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1903214 regulation of protein targeting to mitochondrion
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO:1903852 positive regulation of cristae formation
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904544 positive regulation of free ubiquitin chain polymerization
GO:1904783 positive regulation of NMDA glutamate receptor activity
GO:1904841 TORC2 complex binding
GO:1904881 cellular response to hydrogen sulfide
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2001171 positive regulation of ATP biosynthetic process
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion inner membrane
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR040110 PINK1, protein kinase domainDomainDomain

Diseases

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Interactions

86 interactions

InteractorPartnerSourcesPublicationsLink
PINK1_HUMANPRKN_HUMANBioGRID, DIP, IntAct, MINT17052189 19167501 19229105 19358826 19880420 19966284 20153330 20798600 22724072 23319602 23670163 23933751 24357652 25474007 25591737 26116755 26162776 27528605 27605430 28945249 29330382 details
PINK1_HUMANFBX7_HUMANBioGRID, IntAct23933751 32493843 details
PINK1_HUMANHSH2D_HUMANBioGRID, IntAct25814554 details
PINK1_HUMANSOCS4_HUMANBioGRID, IntAct25814554 details
PINK1_HUMANSTAT3_HUMANBioGRID, IntAct25814554 details
PINK1_HUMANDP13B_HUMANBioGRID, IntAct25814554 details
PINK1_HUMANTRAP1_HUMANBioGRID, DIP17579517 31300519 details
PINK1_HUMANAP2B1_HUMANIntAct32814053 details
PINK1_HUMANZN366_HUMANIntAct32814053 details
PINK1_HUMANLDH6B_HUMANIntAct32814053 details
PINK1_HUMANVPS29_HUMANIntAct32814053 details
PINK1_HUMANSPAG8_HUMANIntAct32814053 details
PINK1_HUMANPDZ1I_HUMANIntAct32814053 details
PINK1_HUMANIQEC1_HUMANIntAct32814053 details
PINK1_HUMANFEZ2_HUMANIntAct32814053 details
PINK1_HUMANTEAD1_HUMANIntAct32814053 details
PINK1_HUMANPNPH_HUMANIntAct32814053 details
PINK1_HUMANBIRC5_HUMANIntAct32814053 details
PINK1_HUMANA4_HUMANIntAct32814053 details
PINK1_HUMANHD_HUMANIntAct32814053 details
PINK1_HUMANPINK1_HUMANBioGRID, HPRD14607334 22280891 22724072 30783609 31300519 details
PINK1_HUMANPGAM5_HUMANBioGRID21151955 31177901 details
PINK1_HUMANSNCAP_HUMANBioGRID15894486 details
PINK1_HUMANSYUA_HUMANBioGRID19167501 27334109 details
PINK1_HUMANMARK2_HUMANBioGRID22238344 details
PINK1_HUMANPARK7_HUMANBioGRID16632486 19229105 details
PINK1_HUMANUBC12_HUMANBioGRID22388932 details
PINK1_HUMANTRAF6_HUMANBioGRID22643835 23885119 details
PINK1_HUMANM3K7_HUMANBioGRID22643835 details
PINK1_HUMANBAG2_HUMANBioGRID24383081 24513209 details
PINK1_HUMANCRLS1_HUMANBioGRID24703837 details
PINK1_HUMANUBC_HUMANBioGRID24751536 24784582 25474007 25847540 26162776 27605430 28438176 31300519 details
PINK1_HUMANB2CL1_HUMANBioGRID24999239 32088314 details
PINK1_HUMANTGM2_HUMANBioGRID25557247 details
PINK1_HUMANHCD2_HUMANBioGRID25591737 31300519 details
PINK1_HUMANDNM1L_HUMANBioGRID25591737 details
PINK1_HUMANBAG5_HUMANBioGRID24475098 details
PINK1_HUMANKAPCA_HUMANBioGRID30783609 details
PINK1_HUMANNED4L_HUMANBioGRID32140098 details
PINK1_HUMANMLP3B_HUMANBioGRID, MINT20153330 30907226 details
PINK1_HUMANTOM20_HUMANBioGRID, MINT20153330 22280891 23885119 24357652 details
PINK1_HUMANMIRO1_HUMANBioGRID, IntAct22078885 22396657 details
PINK1_HUMANHS90B_HUMANBioGRID, IntAct18003639 22939624 31300519 details
PINK1_HUMANTIM23_HUMANMINT24357652 details
PINK1_HUMANCDC37_HUMANBioGRID, IntAct18003639 18359116 21151955 25036637 28438176 30783609 details
PINK1_HUMANIKBE_HUMANIntAct29128334 details
PINK1_HUMANCLUS_HUMANIntAct31413325 details
PINK1_HUMANPTEN_HUMANBioGRID15717329 details
PINK1_HUMANHS90A_HUMANBioGRID18003639 18359116 21151955 22939624 28438176 31300519 details
PINK1_HUMANHSP74_HUMANBioGRID18359116 21151955 31300519 details
PINK1_HUMANPARL_HUMANBioGRID21355049 details
PINK1_HUMANMLP3A_HUMANBioGRID20153330 details
PINK1_HUMANHTRA2_HUMANBioGRID17906618 details
PINK1_HUMANTOM40_HUMANBioGRID22280891 28438176 30783609 details
PINK1_HUMANTOM70_HUMANBioGRID22280891 details
PINK1_HUMANTOM22_HUMANBioGRID22280891 details
PINK1_HUMANRICTR_HUMANBioGRID21177249 details
PINK1_HUMANSIN1_HUMANBioGRID21177249 details
PINK1_HUMANAKT1_HUMANBioGRID21177249 details
PINK1_HUMANCSN8_HUMANBioGRID22388932 details
PINK1_HUMANTOLIP_HUMANBioGRID23244239 details
PINK1_HUMANIRAK1_HUMANBioGRID23244239 31300519 details
PINK1_HUMANVIME_HUMANBioGRID23885119 31300519 details
PINK1_HUMANSARM1_HUMANBioGRID23885119 details
PINK1_HUMANHS71A_HUMANBioGRID23885119 31300519 details
PINK1_HUMANHS71B_HUMANBioGRID23885119 31300519 details
PINK1_HUMANRBCC1_HUMANBioGRID23885119 details
PINK1_HUMANB2CL2_HUMANBioGRID24999239 details
PINK1_HUMANMCL1_HUMANBioGRID24999239 details
PINK1_HUMANMIRO2_HUMANBioGRID19152501 details
PINK1_HUMANMIC60_HUMANBioGRID19152501 27153535 details
PINK1_HUMANULA1_HUMANBioGRID22388932 details
PINK1_HUMANBNIP3_HUMANBioGRID27528605 details
PINK1_HUMANSAM50_HUMANBioGRID27153535 29874585 details
PINK1_HUMANSQSTM_HUMANBioGRID30907226 31300519 details
PINK1_HUMANULK1_HUMANBioGRID30907226 details
PINK1_HUMANTRAF3_HUMANBioGRID31139191 details
PINK1_HUMANIRF3_HUMANBioGRID31139191 details
PINK1_HUMANYAP1_HUMANBioGRID31139191 details
PINK1_HUMANTERA_HUMANBioGRID30783609 31300519 details
PINK1_HUMANNSF1C_HUMANBioGRID30783609 details
PINK1_HUMANBAG6_HUMANBioGRID31300519 32332095 details
PINK1_HUMANUBE4B_HUMANBioGRID31300519 details
PINK1_HUMANSC61B_HUMANBioGRID31300519 details
PINK1_HUMANAMFR_HUMANBioGRID31300519 details
PINK1_HUMANFKBP5_HUMANBioGRID30734931 details