Entity Details

Primary name SPRTN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H040
EntryNameSPRTN_HUMAN
FullNameDNA-dependent metalloprotease SPRTN
TaxID9606
Evidenceevidence at protein level
Length489
SequenceStatuscomplete
DateCreated2007-12-04
DateModified2021-06-02

Ontological Relatives

GenesSPRTN

GO terms

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GOName
GO:0000785 chromatin
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0004222 metalloendopeptidase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006508 proteolysis
GO:0006974 cellular response to DNA damage stimulus
GO:0009411 response to UV
GO:0016540 protein autoprocessing
GO:0016607 nuclear speck
GO:0019985 translesion synthesis
GO:0031398 positive regulation of protein ubiquitination
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0070987 error-free translesion synthesis
GO:0106300 protein-DNA covalent cross-linking repair

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR006640 SprT-likeDomainDomain
IPR006642 Rad18, zinc finger UBZ4-typeDomainDomain
IPR044245 SprT-like domain-containing protein SpartanFamilyFamily

Diseases

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Interactions

88 interactions

InteractorPartnerSourcesPublicationsLink
SPRTN_HUMANPCNA_HUMANBioGRID22681887 22894931 22902628 22987070 23042605 23042607 27871366 details
SPRTN_HUMANVCIP1_HUMANBioGRID22902628 32649882 details
SPRTN_HUMANTERA_HUMANBioGRID22902628 23042605 23042607 31477623 details
SPRTN_HUMANDPOD3_HUMANBioGRID22902628 23254330 details
SPRTN_HUMANUBC_HUMANBioGRID22681887 22894931 23042605 23042607 details
SPRTN_HUMANRNF11_HUMANHPRD15231748 details
SPRTN_HUMANRAD18_HUMANBioGRID22681887 22902628 details
SPRTN_HUMANSLX4_HUMANBioGRID22902628 details
SPRTN_HUMANUBXN1_HUMANBioGRID22902628 details
SPRTN_HUMANBACD1_HUMANBioGRID22902628 details
SPRTN_HUMANHLTF_HUMANBioGRID22902628 details
SPRTN_HUMANCAND1_HUMANBioGRID22902628 details
SPRTN_HUMANPOLH_HUMANBioGRID22902628 details
SPRTN_HUMANRFA1_HUMANBioGRID22894931 details
SPRTN_HUMANUFD1_HUMANBioGRID23042607 details
SPRTN_HUMANNSF1C_HUMANBioGRID23042607 details
SPRTN_HUMANNPL4_HUMANBioGRID23042607 details
SPRTN_HUMANMLH1_HUMANBioGRID23042605 details
SPRTN_HUMANLACTB_HUMANBioGRID23042605 details
SPRTN_HUMANSSBP_HUMANBioGRID23042605 details
SPRTN_HUMANHSP7C_HUMANBioGRID23042605 details
SPRTN_HUMANHS71A_HUMANBioGRID23042605 details
SPRTN_HUMANHS71B_HUMANBioGRID23042605 details
SPRTN_HUMANTBB6_HUMANBioGRID23042605 details
SPRTN_HUMANAGM1_HUMANBioGRID23042605 details
SPRTN_HUMANDNJA2_HUMANBioGRID23042605 details
SPRTN_HUMANTBB4B_HUMANBioGRID23042605 details
SPRTN_HUMANATX3_HUMANBioGRID23042605 details
SPRTN_HUMANCLIC4_HUMANBioGRID23042605 details
SPRTN_HUMANPMS2_HUMANBioGRID23042605 details
SPRTN_HUMANFZR1_HUMANBioGRID23042605 details
SPRTN_HUMANDPOD1_HUMANBioGRID23254330 27871366 details
SPRTN_HUMANDPOD2_HUMANBioGRID23254330 details
SPRTN_HUMANDPOD4_HUMANBioGRID23254330 details
SPRTN_HUMANATPA_HUMANBioGRID23254330 details
SPRTN_HUMANTIF1B_HUMANBioGRID23254330 details
SPRTN_HUMANDYHC1_HUMANBioGRID23254330 details
SPRTN_HUMANYBOX1_HUMANBioGRID23254330 details
SPRTN_HUMANRCN2_HUMANBioGRID23254330 details
SPRTN_HUMANHUWE1_HUMANBioGRID23254330 details
SPRTN_HUMANMAGD2_HUMANBioGRID23254330 details
SPRTN_HUMANF120A_HUMANBioGRID23254330 details
SPRTN_HUMANAKA12_HUMANBioGRID23254330 details
SPRTN_HUMANANXA2_HUMANBioGRID23254330 details
SPRTN_HUMANVIME_HUMANBioGRID23254330 details
SPRTN_HUMANSTAU1_HUMANBioGRID23254330 details
SPRTN_HUMANPSMD3_HUMANBioGRID23254330 details
SPRTN_HUMANPRS7_HUMANBioGRID23254330 details
SPRTN_HUMANLAP2A_HUMANBioGRID23254330 details
SPRTN_HUMANLAP2B_HUMANBioGRID23254330 details
SPRTN_HUMANPHB_HUMANBioGRID23254330 details
SPRTN_HUMANDNJC7_HUMANBioGRID23254330 details
SPRTN_HUMANDDX17_HUMANBioGRID23254330 details
SPRTN_HUMANGRP75_HUMANBioGRID23254330 details
SPRTN_HUMANAT1A1_HUMANBioGRID23254330 details
SPRTN_HUMANAT2A2_HUMANBioGRID23254330 details
SPRTN_HUMANZCCHV_HUMANBioGRID23254330 details
SPRTN_HUMANUBB_HUMANBioGRID23254330 details
SPRTN_HUMANPYR1_HUMANBioGRID23254330 details
SPRTN_HUMANATPB_HUMANBioGRID23254330 details
SPRTN_HUMANH1X_HUMANBioGRID23254330 details
SPRTN_HUMANH2B1K_HUMANBioGRID23254330 details
SPRTN_HUMANH2B1N_HUMANBioGRID23254330 details
SPRTN_HUMANH2B1H_HUMANBioGRID23254330 details
SPRTN_HUMANH2B1C_HUMANBioGRID23254330 details
SPRTN_HUMANH2B1L_HUMANBioGRID23254330 details
SPRTN_HUMANH2B1M_HUMANBioGRID23254330 details
SPRTN_HUMANH2B2F_HUMANBioGRID23254330 details
SPRTN_HUMANH2B1D_HUMANBioGRID23254330 details
SPRTN_HUMANVDAC1_HUMANBioGRID23254330 details
SPRTN_HUMANSRSF1_HUMANBioGRID23254330 details
SPRTN_HUMANSRSF5_HUMANBioGRID23254330 details
SPRTN_HUMANHNRDL_HUMANBioGRID23254330 details
SPRTN_HUMANPSMD4_HUMANBioGRID23254330 details
SPRTN_HUMANRBM39_HUMANBioGRID23254330 details
SPRTN_HUMANHNRPQ_HUMANBioGRID23254330 details
SPRTN_HUMANSTRAP_HUMANBioGRID23254330 details
SPRTN_HUMANDDX5_HUMANBioGRID23254330 details
SPRTN_HUMANSYDC_HUMANBioGRID23254330 details
SPRTN_HUMANLMNB1_HUMANBioGRID23254330 details
SPRTN_HUMANCTBP2_HUMANBioGRID23254330 details
SPRTN_HUMANCKAP4_HUMANBioGRID23254330 details
SPRTN_HUMANLPPRC_HUMANBioGRID23254330 details
SPRTN_HUMANRFC1_HUMANBioGRID23254330 details
SPRTN_HUMANUBR5_HUMANBioGRID23254330 details
SPRTN_HUMANEFTU_HUMANBioGRID23254330 details
SPRTN_HUMANMCM2_HUMANBioGRID27871366 details
SPRTN_HUMANMCM6_HUMANBioGRID27871366 details