Entity Details

Primary name TBB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H4B7
EntryNameTBB1_HUMAN
FullNameTubulin beta-1 chain
TaxID9606
Evidenceevidence at protein level
Length451
SequenceStatuscomplete
DateCreated2005-02-01
DateModified2021-06-02

Ontological Relatives

GenesTUBB1

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0051225 spindle assembly
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000217 TubulinFamilyFamily
IPR002453 Beta tubulinFamilyFamily
IPR003008 Tubulin/FtsZ, GTPase domainDomainDomain
IPR008280 Tubulin/FtsZ, C-terminalFamilyHomologous superfamily
IPR013838 Beta tubulin, autoregulation binding siteSiteBinding site
IPR017975 Tubulin, conserved siteSiteConserved site
IPR018316 Tubulin/FtsZ, 2-layer sandwich domainDomainDomain
IPR023123 Tubulin, C-terminalFamilyHomologous superfamily
IPR036525 Tubulin/FtsZ, GTPase domain superfamilyFamilyHomologous superfamily
IPR037103 Tubulin/FtsZ-like, C-terminal domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00309 VindesineDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01248 DocetaxelDrugbanksmall molecule
DB01873 Epothilone DDrugbanksmall molecule
DB03010 PatupiloneDrugbanksmall molecule
DB05147 CYT997Drugbanksmall molecule
DB06042 ZEN-012Drugbanksmall molecule
DB06772 CabazitaxelDrugbanksmall molecule
DB08871 EribulinDrugbanksmall molecule
DB12334 MilataxelDrugbanksmall molecule
DB12695 Phenethyl IsothiocyanateDrugbanksmall molecule